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(S)-3-N-Boc-aminopiperidine
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Name

(S)-3-N-Boc-aminopiperidine

 EINECS 626-980-5
CAS No. 216854-23-8 Density 1.02 g/cm3
PSA 50.36000 LogP 1.98280
Solubility N/A Melting Point 122-127 °C
Formula C10H20N2O2 Boiling Point 304.8 °C at 760 mmHg
Molecular Weight 200.281 Flash Point 138.2 °C
Transport Information N/A Appearance N/A
Safety 26-39 Risk Codes 37/38-41
Molecular Structure Molecular Structure of 216854-23-8 ((S)-3-N-Boc-aminopiperidine) Hazard Symbols IrritantXi
Synonyms

Carbamicacid, (3S)-3-piperidinyl-, 1,1-dimethylethyl ester (9CI);(S)-(-)-3-(tert-Butoxycarbonylamino)piperidine;(S)-3-tert-Butoxycarbonylaminopiperidine;(S)-tert-ButylN-[piperidin-3-yl]carbamate;tert-Butyl ((3S)-piperidin-3-yl)carbamate;

Article Data 3

(S)-3-N-Boc-aminopiperidine Synthetic route

92235-39-7

3(S)-<(butoxycarbonyl)amino>-2-oxopiperidine

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

Conditions
ConditionsYield
With borane-THF In tetrahydrofuran at 0 - 25℃; for 6.75h;30%
607376-86-3

(S)-2-(tert-butoxycarbonylamino)pentane-1,5-diyl dimethanesulfonate

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

Conditions
ConditionsYield
With ammonium hydroxide In acetonitrile for 48h; Ambient temperature; Yield given;
56-86-0

L-glutamic acid

2-benzyloxycarbonylaminomethyl-4-benzyliden-Δ2-oxazolinone-(5)

2-benzyloxycarbonylaminomethyl-4-benzyliden-Δ2-oxazolinone-(5)

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

Conditions
ConditionsYield
Multi-step reaction with 5 steps
1: H2SO4 / 2 h / Heating
2: Et3N / dioxane; H2O / 2 h / 0 °C
3: NaBH4, CaCl2 / ethanol / 2 h / 0 °C
4: Et3N / CH2Cl2 / 1 h / -10 - 0 °C
5: aq. NH4OH / acetonitrile / 48 h / Ambient temperature
View Scheme
6525-53-7, 16422-27-8, 40149-68-6

L-glutamic acid dimethyl ester

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1: Et3N / dioxane; H2O / 2 h / 0 °C
2: NaBH4, CaCl2 / ethanol / 2 h / 0 °C
3: Et3N / CH2Cl2 / 1 h / -10 - 0 °C
4: aq. NH4OH / acetonitrile / 48 h / Ambient temperature
View Scheme
59279-60-6, 130622-05-8

dimethyl (2S)-2-[(tert-butoxycarbonyl)amino]pentanedioate

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: NaBH4, CaCl2 / ethanol / 2 h / 0 °C
2: Et3N / CH2Cl2 / 1 h / -10 - 0 °C
3: aq. NH4OH / acetonitrile / 48 h / Ambient temperature
View Scheme
162955-48-8

[(1S)-4-hydroxy-1-(hydroxymethyl)butyl]carbamic acid tert-butyl ester

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: Et3N / CH2Cl2 / 1 h / -10 - 0 °C
2: aq. NH4OH / acetonitrile / 48 h / Ambient temperature
View Scheme
1188914-98-8

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

1188915-59-4

tert-butyl (R)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate

Conditions
ConditionsYield
at 20℃;100%
1527525-60-5

1-[5-(difluoromethyl)-6-fluoro-2-pyridyl]-6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridine

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

1527525-62-7

tert-butyl N-[(3S)-1-[3-(difluoromethyl)-6-[6-(6-methylpyrazin-2-yl)pyrazolo[4,3-c]pyridin-1-yl]-2-pyridyl]-3-piperidyl]carbamate

Conditions
ConditionsYield
With 4-methyl-morpholine In 1-methyl-pyrrolidin-2-one at 100℃; Sealed tube;100%
23680-84-4

2-chloro-6,7-dimethoxyquinazolin-4-amine

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

tert-butyl (S)-(1-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperidin-3-yl)carbamate

Conditions
ConditionsYield
In i-Amyl alcohol at 130℃; under 760.051 Torr; for 0.833333h; Microwave irradiation;100%
1188914-98-8

1-[4-chloro-6-(4-morpholinyl)-1,3,5-triazin-2-yl]-2-(difluoromethyl)-4-methoxy-1H-benzimidazole

216854-23-8

tert-butyl (S)-piperidin-3-yl-carbamate

1188915-61-8

tert-butyl (S)-1-[4-[2-(difluoromethyl)-4-methoxy-1H-benzimidazol-1-yl]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]piperidin-3-ylcarbamate

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃;100%

(S)-3-N-Boc-aminopiperidine Chemical Properties

IUPAC Name: tert-butyl N-[(3S)-piperidin-3-yl]carbamate
Synonyms: (S)-TERT-BUTYL-PIPERIDIN-3-YLCARBAMATE;Carbamic acid, (3S)-3-piperidinyl-, 1,1-dimethylethyl ester (9CI);(S)-PIPERIDIN-3-YL-CARBAMIC ACID TERT-BUTYL ESTER;;(S)-3-N-BOC-AMINOPIPERIDINE;(S)-3-BOC-AMINOPIPERIDINE;CARBAMIC ACID, (3S)-3-PIPERIDINYL-, 1,1-DIMETHYLETHYL ESTER;(S)-(-)-3-TERT-BUTOXYCARBONYLAMINOPIPERIDINE;(S)-3-(TERT-BUTOXYCARBONYLAMINO)PIPERIDINE
The Molecular formula of (S)-3-N-Boc-aminopiperidine(216854-23-8): C10H20N2O2
The Molecular Weight of (S)-3-N-Boc-aminopiperidine(216854-23-8): 200.28
Molecular Structure : 
Melting point: 122-127°C
alpha: -3 o (c=1, DMF)

(S)-3-N-Boc-aminopiperidine Safety Profile

The Hazard Codes of (S)-3-N-Boc-aminopiperidine(216854-23-8):  Xi
The Risk Statements information of (S)-3-N-Boc-aminopiperidine(216854-23-8):
41:  Risk of serious damage to eyes 
37/38:  Irritating to respiratory system and skin 
The Safety Statements information of (S)-3-N-Boc-aminopiperidine(216854-23-8):
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
39:  Wear eye/face protection 
WGK Germany: 3

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