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1,2,4-Trifluorobenzene

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Name

1,2,4-Trifluorobenzene

EINECS 206-684-9
CAS No. 367-23-7 Density 1.294 g/cm3
PSA 0.00000 LogP 2.10390
Solubility N/A Melting Point -35oC
Formula C6H3F3 Boiling Point 90.7 °C at 760 mmHg
Molecular Weight 132.085 Flash Point 4.4 °C
Transport Information UN 1993 3/PG 2 Appearance clear colourless liquid
Safety 16-26-36-7-33-29-7/9 Risk Codes 11-36/37/38
Molecular Structure Molecular Structure of 367-23-7 (1,2,4-Trifluorobenzene) Hazard Symbols FlammableF,IrritantXi
Synonyms

1,3, 4-Trifluorobenzene;Benzene, 1,2,4-trifluoro-;1,3,4-Trifluorobenzene, misnomer;

Article Data 58

1,2,4-Trifluorobenzene Synthetic route

7800-26-2

2,4-dinitro-1-fluorobenzene

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With tetrabutyl ammonium fluoride In dimethyl sulfoxide at 25℃; for 0.166667h; Inert atmosphere; Microwave irradiation; Anhydrous conditions;95%
446-17-3

2,4,5-trifluorobenzoic acid

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With ammonia; copper In water at 260℃; for 1.25h; Temperature; Reagent/catalyst;94.9%
In quinoline
551-62-2

1,2,3,4-tetrafluorobenzene

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With [(bis(diisopropylphosphino)ethane)Ni(H)]2; triethylphosphine In 1,4-dioxane at 120℃; for 72h;94%
With C32H46N2Ru; sodium carbonate; isopropyl alcohol at 70℃; for 6h; Inert atmosphere; Schlenk technique; Glovebox;63%
With (1,3-dimethylimidazolin-2-ylidene)*AlH3 In 5,5-dimethyl-1,3-cyclohexadiene at 135℃; for 25h;19%
165047-24-5

2,4,5-trifluorobenzaldehyde

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With triethylsilane; C18H51CoP4Si In tetrahydrofuran at 50℃; for 6h; Inert atmosphere;94%
769-40-4

2,3,5,6-tetrafluorothiophenol

A

651-80-9

1,2,4,5-tetrafluoro-3-(trifluoromethyl)benzene

B

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With water; triethylphosphine In 1,4-dioxane at 120℃; for 4h; Schlenk technique; Inert atmosphere; Glovebox;A 90%
B 10%

C6H3FN4(2+)*2BF4(1-)

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
In diethyl ether at 120 - 180℃; for 6h;82%
367-25-9

2,4-difluorophenylamine

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
Stage #1: 2,4-difluorophenylamine With sodium tetrafluoroborate; nitrosylsulfuric acid; acetic acid at -5 - 20℃;
Stage #2: at 250℃; Inert atmosphere;
80%
Stage #1: 2,4-difluorophenylamine With hydrogenchloride; fluoroboric acid; sodium nitrite In water at 25℃; for 0.00555556h; Balz-Schiemann Reaction;
Stage #2: In 1,2-dichloro-benzene at 200℃; for 0.0166667h; Balz-Schiemann Reaction;
72%
120-82-1

1,2,4-Trichlorobenzene

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With potassium fluoride; C6H11BO3 In sulfolane (tetramethylene sulfone) at 245℃; for 3h; Inert atmosphere;78%
392-56-3

Hexafluorobenzene

A

327-54-8

1,2,4,5-Tetrafluorobenzene

B

551-62-2

1,2,3,4-tetrafluorobenzene

C

363-72-4

Pentafluorobenzene

D

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With (1,3-dimethylimidazolin-2-ylidene)*AlH3 In 5,5-dimethyl-1,3-cyclohexadiene at 135℃; for 25h;A 74%
B 3%
C 18%
D 4%
363-72-4

Pentafluorobenzene

A

540-36-3

para-difluorobenzene

B

327-54-8

1,2,4,5-Tetrafluorobenzene

C

367-23-7

1,2,4-trifluorobenzene

Conditions
ConditionsYield
With C32H46N2Ru; sodium carbonate; isopropyl alcohol at 70℃; for 4h; Inert atmosphere; Schlenk technique; Glovebox;A 7%
B 60%
C 21%

1,2,4-Trifluorobenzene Chemical Properties

The Molecular formula of  1,2,4-Trifluorobenzene(367-23-7) : C6H3F3

The Molecular Weight of  1,2,4-Trifluorobenzene(367-23-7) : 132.08
Molecular Structure :

Boiling point : 88-91°C

Density: 1.264

Flash point: 4°C

Refractive index: 1.422-1.424

1,2,4-Trifluorobenzene Toxicity Data With Reference

1,2,4-Trifluorobenzene(367-23-7) is highly flammable.

1,2,4-Trifluorobenzene(367-23-7) is irritating to eyesrespiratory system and skin.

1,2,4-Trifluorobenzene Safety Profile

Keep 1,2,4-Trifluorobenzene(367-23-7) away from sources of ignition.

The Hazard Codes of   1,2,4-Trifluorobenzene(367-23-7) : F,  Xi
WGK Germany:3
RIDADR:UN 1993 3/PG 2
Hazard Note:Flammable
HazardClass:3

1,2,4-Trifluorobenzene Specification

Stability:Stable at room temperature in closed containers under normal storage and handling conditions.
Incompatibilities:Strong oxidizing agents.
Decomposition:Carbon monoxide, carbon dioxide, HYDROGEN FLUORIDE.
Combustion Products:Fire may produce irritating, corrosive and/or toxic gases.
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