NTP 10th Report on Carcinogens. IARC Cancer Review: Group 2B IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 7 , 1987,p. 201.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) ; Animal Sufficient Evidence IMEMDT    IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man . 11 , 1976,p. 247.(World Health Organization, Internation Agency for Research on Cancer,Lyon, France.: ) (Single copies can be ordered from WHO Publications Centre U.S.A., 49 Sheridan Avenue, Albany, NY 12210) . NCI Carcinogenesis Bioassay (oral); Clear Evidence: mouse, rat NCITR*    National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD 20014) No. NCI-CG-TR-80 ,1978. . EPA Genetic Toxicology Program. Glycol ether compounds are on the Community Right-To-Know List. Reported in EPA TSCA Inventory.

OSHA PEL: TWA 25 ppm (skin)
ACGIH TLV: TWA 20 ppm (skin); Confirmed Animal Carcinogen with Unknown Revelance to Humans
DFG MAK: 20 ppm (73 mg/m³); Not Classifiable as a Human Carcinogen
NIOSH REL: CL (Dioxane) 1 ppm/30M
DOT Classification:  3; Label: Flammable Liquid

For occupational chemical analysis use NIOSH: Dioxane (CAS NO.123-91-1), 1602.

The CAS registry number of Dioxane is 123-91-1. The IUPAC name is 1,4-dioxane. Its EINECS registry number is 204-661-8. In addition, the molecular formula is C₄H₈O₂ and the molecular weight is 88.11. It is a kind of colourless liquid and belongs to the classes of Pharmaceutical Intermediates; Organics; API Intermediates; Dioxanes; Dioxanes & Dioxolanes; DioxanesCosmetics; Allergens; Alpha Sort; D; DAlphabetic; DIO - DIZEnvironmental Standards.

Physical properties about this chemical are: (1)ACD/LogP: -0.27; (2)ACD/LogD (pH 5.5): -0.27; (3)ACD/LogD (pH 7.4): -0.27; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 16.97; (7)ACD/KOC (pH 7.4): 16.97; (8)#H bond acceptors: 2; (9)Polar Surface Area: 18.46 Å²; (10)Index of Refraction: 1.404; (11)Molar Refractivity: 21.65 cm³; (12)Molar Volume: 88.5 cm³; (13)Polarizability: 8.58 ×10^-24cm³; (14)Surface Tension: 31.2 dyne/cm; (15)Density: 0.995 g/cm³; (16)Flash Point: 12.2 °C; (17)Enthalpy of Vaporization: 34.16 kJ/mol; (18)Boiling Point: 102.9 °C at 760 mmHg; (19)Vapour Pressure: 38.2 mmHg at 25°C.

Preparation of Dioxane: it is produced by the acid-catalysed dehydration of diethylene glycol, which in turn arises from the hydrolysis of ethylene oxide. And it can be prepared by ethane-1,2-diol. This reaction will need catalyst Nafion-H. The reaction time is 5 hours at reaction temperature of 135 °C. The yield is about 50%.

Uses of Dioxane: it is an occasionally used solvent for a variety of practical applications as well as in the laboratory. And it can be used to get [1,4]dioxan-2-one. This reaction will need reagents Me₃SiONO₂ and CrO₃ and solvent acetonitrile. The reaction time is 24 hours at ambient temperature. The yield is about 53%.

When you are using this chemical, please be cautious about it as the following:
It is highly flammable and irritating to eyes, skin and respiratory system. And it has danger of serious damage to health by prolonged exposure through inhalation, in contact with skin and if swallowed. It may cause cancer, heritable genetic damage and lung damage if swallowed. Avoid exposure - obtain special instruction before use. During using it, wear suitable protective clothing and gloves and avoid contact with skin and eyes. You should not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer). If in case of contact with eyes, rinse immediately with plenty of water and seek medical advice. If swallowed, do not induce vomiting, you should seek medical advice immediately and show this container or label. Keep container tightly closed. Keep container in a well-ventilated place. When store it, keep away from sources of ignition-No smoking.

You can still convert the following datas into molecular structure:
(1)SMILES: O1CCOCC1
(2)InChI: InChI=1/C4H8O2/c1-2-6-4-3-5-1/h1-4H2
(3)InChIKey: RYHBNJHYFVUHQT-UHFFFAOYAN

The toxicity data is as follows: