- 25133-97-5Acrylates copolymer
- 25134-21-8Methyl nadic anhydride
- 251349-56-14-Thiazolecarboxylicacid, 2-(2S)-2-pyrrolidinyl-, ethyl ester
- 25135-51-7Poly[oxy-1,4-phenylenesulfonyl-1,4-phenyleneoxy-1,4-phenylene(1-methylethylidene)-1,4-phenylene]
- 25136-46-3Nickel,tris(triphenylphosphine)-
- 25136-75-8Polyquaternium-39
- 25137-00-23-Piperidinecarboxylicacid, (3R)-
- 25137-01-3(R)-Nipecotic acid ethyl ester
- 25140-86-7Propanoic acid,2-(2-chlorophenoxy)-
- 25140-90-3Propanoic acid,2-(2,6-dichlorophenoxy)-
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
2-(Dicyclohexylphosphino)-2'-methylbiphenyl |
EINECS | 607-557-4 |
| CAS No. | 251320-86-2 | Density | N/A |
| PSA | 13.59000 | LogP | 7.43460 |
| Solubility | insoluble in water | Melting Point |
107-111 °C |
| Formula | C25H33P | Boiling Point | 499.3 °C at 760 mmHg |
| Molecular Weight | 364.511 | Flash Point | 271.5 °C |
| Transport Information | N/A | Appearance | White crystals or crystalline powder |
| Safety | 37/39-26 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
MePhos;2-Dicyclohexylphosphino-2'-methylbiphenyl; |
Article Data | 5 |
2-(Dicyclohexylphosphino)-2'-methylbiphenyl Synthetic route
- 251320-87-3
2-bromo-2'-methylbiphenyl
- 16523-54-9
chlorodicyclohexylphosphane
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Stage #1: 2-bromo-2'-methylbiphenyl With n-butyllithium In tetrahydrofuran at -78℃; for 1.16667h; Metallation; Stage #2: chlorodicyclohexylphosphane In tetrahydrofuran Condensation; a) -78 deg C, 20 min, b) 0 deg C, 20 min, c) RT, 18 h; | 65% |
- 694-80-4
2-bromo-1-chlorobenzene
- 95-49-8
2-methylchlorobenzene
- 931-51-1
cyclohexylmagnesiumchloride
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Multistep reaction.; | 59% |
- 694-80-4
2-bromo-1-chlorobenzene
- 95-46-5
2-methylphenyl bromide
- 16523-54-9
chlorodicyclohexylphosphane
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Stage #1: 2-methylphenyl bromide With magnesium; ethylene dibromide In tetrahydrofuran for 2h; Inert atmosphere; Reflux; Industrial scale; Stage #2: 2-bromo-1-chlorobenzene With magnesium In tetrahydrofuran for 2h; Inert atmosphere; Reflux; Industrial scale; Stage #3: chlorodicyclohexylphosphane With copper(l) chloride In tetrahydrofuran at 20℃; Thermodynamic data; Inert atmosphere; Industrial scale; | 55% |
- 19493-31-3
2-chloro-2'-methyl-1,1'-biphenyl
- 16523-54-9
chlorodicyclohexylphosphane
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Stage #1: 2-chloro-2'-methyl-1,1'-biphenyl With sec.-butyllithium In diethyl ether; cyclohexane at -78 - -45℃; Inert atmosphere; Stage #2: chlorodicyclohexylphosphane In diethyl ether; cyclohexane at -78℃; Inert atmosphere; | 52% |
- 694-80-4
2-bromo-1-chlorobenzene
- 33872-80-9
o-tolyl magnesium chloride
- 16523-54-9
chlorodicyclohexylphosphane
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Stage #1: o-tolyl magnesium chloride With magnesium In tetrahydrofuran for 0.25h; Heating; Stage #2: 2-bromo-1-chlorobenzene In tetrahydrofuran for 2h; Heating; Stage #3: chlorodicyclohexylphosphane In tetrahydrofuran at 20℃; for 14h; Further stages.; | 51% |
- 931-51-1
cyclohexylmagnesiumchloride
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: PCl3 / diethyl ether / -40 - 20 °C 2.1: Mg / tetrahydrofuran / 0.25 h / Heating 2.2: tetrahydrofuran / 2 h / Heating 2.3: 51 percent / tetrahydrofuran / 14 h / 20 °C View Scheme |
- 583-55-1
1-Bromo-2-iodobenzene
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: 1.57 g / tetrakis(triphenylphosphine)palladium; Na2CO3 / 1,2-dimethoxy-ethane; H2O; ethanol / 42 h / 90 °C 2.1: n-BuLi / tetrahydrofuran / 1.17 h / -78 °C 2.2: 65 percent / tetrahydrofuran / a) -78 deg C, 20 min, b) 0 deg C, 20 min, c) RT, 18 h View Scheme |
- 16419-60-6
2-Methylphenylboronic acid
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: 1.57 g / tetrakis(triphenylphosphine)palladium; Na2CO3 / 1,2-dimethoxy-ethane; H2O; ethanol / 42 h / 90 °C 2.1: n-BuLi / tetrahydrofuran / 1.17 h / -78 °C 2.2: 65 percent / tetrahydrofuran / a) -78 deg C, 20 min, b) 0 deg C, 20 min, c) RT, 18 h View Scheme | |
| Multi-step reaction with 2 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / toluene / 70 °C / Inert atmosphere 2.1: sec.-butyllithium / diethyl ether; cyclohexane / -78 - -45 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere View Scheme |
- 95-50-1
1,2-dichloro-benzene
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: tris-(dibenzylideneacetone)dipalladium(0); caesium carbonate; 1,3,5,7-tetramethyl-8-phenyl-2,4,6-trioxa-8-phosphatricyclo[3.3.1.13,7]decane / toluene / 70 °C / Inert atmosphere 2.1: sec.-butyllithium / diethyl ether; cyclohexane / -78 - -45 °C / Inert atmosphere 2.2: -78 °C / Inert atmosphere View Scheme |
- 39929-21-0
(tetrahydrothiophene)gold(I) chloride
- 251320-86-2
2-(dicyclohexylphosphino)-2'-methylbiphenyl
- 1005420-86-9
dicyclohexyl(2'-methylbiphenyl-2-yl)phosphinegold(I) chloride
| Conditions | Yield |
|---|---|
| In dichloromethane for 1.75h; | 100% |
| In toluene (N2); Au complex added to a soln. of ligand, stirred for 24 h under Ar; evapd. (vac.), pentane added, the solid collected, dried; elem. anal.; | 97% |
2-(Dicyclohexylphosphino)-2'-methylbiphenyl Specification
The CAS register number of 2-(Dicyclohexylphosphino)-2'-methylbiphenyl is 251320-86-2. It also can be called as Phosphine,dicyclohexyl(2'-methyl[1,1'-biphenyl]-2-yl)- and the systematic name about this chemical is dicyclohexyl(2'-methylbiphenyl-2-yl)phosphane. The molecular formula about this chemical is C25H33P and molecular weight is 364.50. It belongs to the Biphenyl & Diphenyl ether.
Physical properties about 2-(Dicyclohexylphosphino)-2'-methylbiphenyl are: (1)ACD/LogP: 8.91; (2)# of Rule of 5 Violations: 1; (3)ACD/LogD (pH 5.5): 8.91; (4)ACD/LogD (pH 7.4): 8.91; (5)ACD/BCF (pH 5.5): 1000000; (6)ACD/BCF (pH 7.4): 1000000; (7)ACD/KOC (pH 5.5): 1668082.63; (8)ACD/KOC (pH 7.4): 1668082.63; (9)#Freely Rotating Bonds: 4; (10)Polar Surface Area: 13.59Å2; (11)Flash Point: 271.5 °C; (12)Enthalpy of Vaporization: 73.85 kJ/mol; (13)Boiling Point: 499.3 °C at 760 mmHg; (14)Vapour Pressure: 1.3E-09 mmHg at 25°C.
When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable gloves and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
You can still convert the following datas into molecular structure:
(1)SMILES: P(c2ccccc2c1ccccc1C)(C3CCCCC3)C4CCCCC4
(2)InChI: InChI=1/C25H33P/c1-20-12-8-9-17-23(20)24-18-10-11-19-25(24)26(21-13-4-2-5-14-21)22-15-6-3-7-16-22/h8-12,17-19,21-22H,2-7,13-16H2,1H3
(3)InChIKey: GPVWUKXZFDHGMZ-UHFFFAOYAR
(4)Std. InChI: InChI=1S/C25H33P/c1-20-12-8-9-17-23(20)24-18-10-11-19-25(24)26(21-13-4-2-5-14-21)22-15-6-3-7-16-22/h8-12,17-19,21-22H,2-7,13-16H2,1H3
(5)Std. InChIKey: GPVWUKXZFDHGMZ-UHFFFAOYSA-N
What can I do for you?
Get Best Price
