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Cas Database |
| Name |
2,6-Dichloro-4-methylnicotinonitrile |
EINECS | 212-873-7 |
| CAS No. | 875-35-4 | Density | 1.42 g/cm3 |
| PSA | 36.68000 | LogP | 2.56848 |
| Solubility | N/A | Melting Point |
108-112 °C(lit.) |
| Formula | C7H4Cl2N2 | Boiling Point | 317.1 °C at 760 mmHg |
| Molecular Weight | 187.028 | Flash Point | 145.5 °C |
| Transport Information | UN 2811 6.1/PG 3 | Appearance | Light yellow powder |
| Safety | 26-36/37/39-45-36 | Risk Codes | 20/21-25-37/38-41-43-36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 T,  Xi
|
| Synonyms |
Nicotinonitrile,2,6-dichloro-4-methyl- (6CI,7CI,8CI);2,6-Dichloro-3-cyano-4-methylpyridine;2,6-Dichloro-4-methyl-3-pyridinecarbonitrile;3-Cyano-2,6-dichloro-4-methylpyridine;Dicnil;NSC 19881; |
Article Data | 30 |
2,6-Dichloro-4-methylnicotinonitrile Synthetic route
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 200℃; for 7h; | 98% |
| With trichlorophosphate at 180℃; for 6h; | 92% |
| With trichlorophosphate at 180℃; for 6h; Sealed tube; | 92% |
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 120℃; for 6h; | 98% |
| With trichlorophosphate at 80℃; Temperature; | 84% |
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 180℃; for 6h; Sealed tube; | 92% |
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
| Conditions | Yield |
|---|---|
| With benzyltrimethylammonium chloride; trichlorophosphate at 120℃; for 8h; | 91% |
| With tetramethlyammonium chloride; trichlorophosphate for 8h; Reflux; | 88% |
| With trichlorophosphate for 8h; Reflux; | 50% |
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
| Conditions | Yield |
|---|---|
| With N-benzyl-N,N,N-triethylammonium chloride; trichlorophosphate at 90℃; for 10h; | 65% |
- 39108-47-9
1-butyl-6-hydroxy-4-methyl-2-oxo-1,2-dihydropyridine-3-carbonitrile
A
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
B
- 168697-58-3
1-butyl-6-chloro-1,2-dihydro-4-methyl-2-oxo-3-pyridinecarbonitrile
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 105℃; for 3h; | A 1% B 62% C 0.12 g |
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
| Conditions | Yield |
|---|---|
| With trichlorophosphate at 120℃; |
- 1026543-43-0
(Z)-4-Butylcarbamoyl-2-cyano-3-methyl-but-2-enoic acid ethyl ester
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: NaOH / 2 h / 140 °C 2: 1 percent / POCl3 / 3 h / 105 °C View Scheme |
- 5444-02-0
2,6-dihydroxy-3-cyano-4-methylpyrimidine
- 141-43-5
ethanolamine
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
| Conditions | Yield |
|---|---|
| With sodium carbonate; trichlorophosphate In quinoline |
- 875-35-4
2,6-dichloro-4-methylnicotinonitrile
- 104-10-9
2-(4'-aminophenyl)ethyl alcohol
- 631899-53-1
2,6-bis[4-(2-hydroxyethyl)phenylamino]-3-cyano-4-methylpyridine
| Conditions | Yield |
|---|---|
| Stage #1: 2,6-dichloro-4-methylnicotinonitrile; 2-(4'-aminophenyl)ethyl alcohol With sodium carbonate at 120 - 195℃; for 18h; Stage #2: With hydrogenchloride In water | 98% |
2,6-Dichloro-4-methylnicotinonitrile Chemical Properties
IUPAC Name: 2,6-dichloro-4-methylpyridine-3-carbonitrile
Empirical Formula: C7H4Cl2N2
Molecular Weight: 187.0261g/mol
EINECS: 212-873-7
Structure of 3-Pyridinecarbonitrile,2,6-dichloro-4-methyl- (CAS NO.875-35-4):
Index of Refraction: 1.574
Molar Refractivity: 43.39 cm3
Molar Volume: 131.4 cm3
Polarizability: 17.2×10-24cm3
Surface Tension: 56.9 dyne/cm
Density: 1.42 g/cm3
Flash Point: 145.5 °C
Enthalpy of Vaporization: 55.84 kJ/mol
Boiling Point: 317.1 °C at 760 mmHg
Vapour Pressure: 0.000395 mmHg at 25°C
Product Categories: Pyridine series;API intermediates;Pyridines;Chloropyridines;Halopyridines;C7 and C8Heterocyclic Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks
Canonical SMILES: CC1=CC(=NC(=C1C#N)Cl)Cl
InChI: InChI=1S/C7H4Cl2N2/c1-4-2-6(8)11-7(9)5(4)3-10/h2H,1H3
InChIKey: LSPMHHJCDSFAAY-UHFFFAOYSA-N
2,6-Dichloro-4-methylnicotinonitrile Safety Profile
Hazard Codes: 
T,
Xi
Risk Statements: 20/21-25-37/38-41-43-36/37/38
R20/21:Harmful by inhalation and in contact with skin.
R25 :Toxic if swallowed.
R37/38:Irritating to respiratory system and skin.
R41:Risk of serious damage to the eyes.
R43:May cause sensitization by skin contact.
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 26-36/37/39-45-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S36:Wear suitable protective clothing.
RIDADR: UN 2811 6.1/PG 3
WGK Germany: 3
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
2,6-Dichloro-4-methylnicotinonitrile Specification
3-Pyridinecarbonitrile,2,6-dichloro-4-methyl- , its cas register number is 875-35-4. It also can be called 2,6-Dichloro-4-methylnicotinonitrile . 3-Pyridinecarbonitrile,2,6-dichloro-4-methyl- (CAS NO.875-35-4) is irritating to eyes, respiratory system and skin and it is toxic if swallowed. What's more, it is risk of serious damage to the eyes and may cause sensitization by skin contact.
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