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2,6-Dichloropyrazine

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Name

2,6-Dichloropyrazine

EINECS 225-316-8
CAS No. 4774-14-5 Density 1.493 g/cm3
PSA 25.78000 LogP 1.78340
Solubility N/A Melting Point 53-56 °C
Formula C4H2Cl2N2 Boiling Point 187.466 °C at 760 mmHg
Molecular Weight 148.979 Flash Point 83.8 °C
Transport Information N/A Appearance White powder
Safety 26-37/39-36/37/39-22-36 Risk Codes 36/37/38-20/21/22
Molecular Structure Molecular Structure of 4774-14-5 (2,6-Dichloropyrazine) Hazard Symbols HarmfulXn, IrritantXi
Synonyms

Pyrazine, 2,6-dichloro-;

Article Data 13

2,6-Dichloropyrazine Synthetic route

14508-49-7

2-chloropyrazin

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With pyridine; chlorine at 110℃; for 2h; Reagent/catalyst;87.3%
With sulfuryl dichloride at 120℃;
2423-84-9

Pyrazin-N.N'-dioxyd

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 6h; Heating;84%
6863-76-9

3-chloropyrazine 1-oxide

A

19745-07-4

2,5-dichloropyrazine

B

4858-85-9

2,3-dichloropyrazine

C

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given;
With 1,8-diazabicyclo[5.4.0]undec-7-ene; trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given;
2423-84-9

Pyrazin-N.N'-dioxyd

A

4858-85-9

2,3-dichloropyrazine

B

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
6863-76-9

3-chloropyrazine 1-oxide

A

14508-49-7

2-chloropyrazin

B

19745-07-4

2,5-dichloropyrazine

C

4858-85-9

2,3-dichloropyrazine

D

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
16025-16-4

2-chloropyrazine 1-oxide

A

14508-49-7

2-chloropyrazin

B

4858-85-9

2,3-dichloropyrazine

C

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
14508-49-7

2-chloropyrazin

7782-50-5

chlorine

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
at 120℃;
290-37-9

1,4-pyrazine

7782-50-5

chlorine

A

14508-49-7

2-chloropyrazin

B

19745-07-4

2,5-dichloropyrazine

C

4858-85-9

2,3-dichloropyrazine

D

4774-14-5

2,6-dichloropyrazine

Conditions
ConditionsYield
at 350℃; Product distribution;
14508-49-7

2-chloropyrazin

A

4774-14-5

2,6-dichloropyrazine

B

2,3-dichloro-pyrazine, 2,5-dichloro-pyrazine

2,3-dichloro-pyrazine, 2,5-dichloro-pyrazine

Conditions
ConditionsYield
With chlorine at 475℃;
290-37-9

1,4-pyrazine

A

4774-14-5

2,6-dichloropyrazine

B

2,3-dichloro-pyrazine, chloropyrazine 2,5-dichloro-pyrazine

2,3-dichloro-pyrazine, chloropyrazine 2,5-dichloro-pyrazine

Conditions
ConditionsYield
With water; chlorine at 350℃;

2,6-Dichloropyrazine Chemical Properties

IUPAC name: 2,6-Dichloropyrazine
Molecular Structure of 2,6-Dichloropyrazine (CAS NO.4774-14-5):
       
Molecular formula: C4H2Cl2N2 
Molecular Weight: 148.98 g/mol
EINECS: 225-316-8
Melting point: 55-58 °C(lit.)
Molar Refractivity: 32.22 cm3
Molar Volume: 99.7 cm3
Flash Point: 83.8 °C
Density: 1.493 g/cm3
Index of Refraction: 1.559
Surface Tension: 51.5 dyne/cm 
Enthalpy of Vaporization: 40.63 kJ/mol
Boiling Point: 187.5 °C at 760 mmHg
Vapour Pressure: 0.867 mmHg at 25 °C
Appearance of 2,6-Dichloropyrazine (CAS NO.4774-14-5) White Powder
Canonical SMILES: C1=C(N=C(C=N1)Cl)Cl
InChI: InChI=1S/C4H2Cl2N2/c5-3-1-7-2-4(6)8-3/h1-2H
InChIKey: LSEAAPGIZCDEEH-UHFFFAOYSA-N

2,6-Dichloropyrazine Uses

 2,6-Dichloropyrazine (CAS NO.4774-14-5) is used for medicine, pesticide intermediates and mainly used as livestock's health medicine intermediate.

2,6-Dichloropyrazine Toxicity Data With Reference

 2,6-Dichloropyrazine (CAS NO.4774-14-5) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65. And the toxicological properties have not been fully investigated. You can see actual entry in RTECS for complete information. 

2,6-Dichloropyrazine Safety Profile

Hazard Symbols: HarmfulXn
Risk Codes: R20/21/22;R36/37/38 
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed. 
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Description: S22;S26;S36/37/39 
S22:Do not breathe dust. 
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. 
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection. 
WGK Germany: 3
HazardClass: Irritant

2,6-Dichloropyrazine Specification

 2,6-Dichloropyrazine , its cas register number is 4774-14-5. It also can be called 2,6-Dichlor-pyrazin ; Pyrazine, 2,6-dichloro- ; and 2,6-Dichloropyrazine,99% .
 2,6-Dichloropyrazine (CAS NO.4774-14-5) is stable under normal temperatures and pressures. And it should avoid the condition like incompatible materials, ignition sources. It is also incompatibilities with other materials strong oxidizing agents, strong reducing agents, strong acids, strong bases. while, its hazardous decomposition products are hydrogen chloride, nitrogen oxides, carbon monoxide, carbon dioxide. And its hazardous polymerization has not been reported. 
 2,6-Dichloropyrazine (CAS NO.4774-14-5) is harmful and irritant. It is irritating to eyes, respiratory system and skin and harmful by inhalation, in contact with skin and if swallowed. So you should in case of contact with eyes, rinse immediately with plenty of water and seek medical advice and wear suitable protective clothing, gloves and eye/face protection and do not empty into drains.

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