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Cas Database |
| Name |
2-Amino-2',5-dichlorobenzophenone |
EINECS | 220-985-2 |
| CAS No. | 2958-36-3 | Density | 1.373 g/cm3 |
| PSA | 43.09000 | LogP | 4.38780 |
| Solubility | Insoluble in water. | Melting Point |
87-89 °C(lit.) |
| Formula | C13H9Cl2NO | Boiling Point | 453.6 °C at 760 mmHg |
| Molecular Weight | 266.127 | Flash Point | 228.1 °C |
| Transport Information | N/A | Appearance | yellow to yellow-green powder |
| Safety | 26-37/39-24/25-36 | Risk Codes | 36/37/38-20/21/22 |
| Molecular Structure |
|
Hazard Symbols |
 Xi,  Xn
|
| Synonyms |
(2-amino-5-chloro-phenyl)-(2-chlorophenyl)methanone;2-Amino-2,5-dichlorobenzophenone;2-Amino-5,2'-dichlorobenzophenone;2-Amino-2',5'-dichlorobenzophenone;2-Amino-5,2'-Dichlorobenzophenone(CCAB);2-Amino-5,2'-Dichloro benzophenone; |
Article Data | 28 |
2-Amino-2',5-dichlorobenzophenone Synthetic route
- 77792-52-0
5-chloro-3-(2-chlorophenyl)-2,1-benzisoxazole
- 2958-36-3
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone
| Conditions | Yield |
|---|---|
| With iron; acetic acid In ethanol; water at 60 - 70℃; for 2h; | 92% |
- 5922-60-1
2-amino-5-chlorobenzonitrile
- 3900-89-8
2-Chlorobenzeneboronic acid
- 2958-36-3
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone
| Conditions | Yield |
|---|---|
| With 5,5'-dimethyl-2,2'-bipyridine; methanesulfonic acid; palladium(II) trifluoroacetate; water In 2-methyltetrahydrofuran at 80℃; for 36h; Schlenk technique; | 52% |
- 609-65-4
o-chlorobenzoyl chloride
- 106-47-8
4-chloro-aniline
- 2958-36-3
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone
| Conditions | Yield |
|---|---|
| (i) ZnCl2, (ii) aq. HCl, (iii) H2SO4; Multistep reaction; | |
| With sulfuric acid; acetic acid; zinc(II) chloride 2) H2O, reflux, 18 h; Yield given. Multistep reaction; | |
| With zinc(II) chloride at 200 - 230℃; for 3h; |
- 2958-36-3
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone
| Conditions | Yield |
|---|---|
| With toluene-4-sulfonic acid In xylene |
| Conditions | Yield |
|---|---|
| With hydrogenchloride for 0.5h; Heating; acid hydrolysis; | |
| With hydroxypropyl-α-cyclodextrin In water for 0.75h; Heating; |
- 848-75-9
lormetazepam
A
- 2958-36-3
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone
B
- 846-49-1
lorazepam
| Conditions | Yield |
|---|---|
| With hydrogenchloride multistep reaction: biotransformation, acid hydrolysis; |
- 848-75-9
lormetazepam
A
- 2958-36-3
(2-amino-5-chloro-phenyl)-(2-chloro-phenyl)-methanone
B
- 5621-86-3
2',5-dichloro-2-methylaminobenzophenone
| Conditions | Yield |
|---|---|
| With hydrogenchloride multistep reaction: acid hydrolysis, photolysis; |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: SOCl2 / Heating 2.1: ZnCl2 / 2 h / 205 °C 2.2: 7- percent H2SO4 / 8 h / Heating View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 12 percent / KOH, K2CO3, H2O / benzene; methanol / 2 h / Ambient temperature 2: 92 percent / Fe/AcOH / H2O; ethanol / 2 h / 60 - 70 °C View Scheme |
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 12 percent / KOH, K2CO3, H2O / benzene; methanol / 2 h / Ambient temperature 2: 92 percent / Fe/AcOH / H2O; ethanol / 2 h / 60 - 70 °C View Scheme |
2-Amino-2',5-dichlorobenzophenone Chemical Properties
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IUPAC Name: (2-Amino-5-chlorophenyl)-(2-chlorophenyl)methanone
Molecular Formula: C13H9Cl2NO
Molecular Weight: 266.13 g/mol
SMILES: c1(C(c2c(cccc2)Cl)=O)c(ccc(c1)Cl)N
InChI: InChI=1/C13H9Cl2NO/c14-8-5-6-12(16)10(7-8)13(17)9-3-1-2-4-11(9)15/h1-7H,16H2
EINECS: 220-985-2
Product Categories: Aromatic Benzophenones & Derivatives (substituted); Benzene series; Cloxazolam; Benzophenones (for High-Performance Polymer Research); Functional Materials; Reagent for High-Performance Polymer Research; Intermediates & Fine Chemicals; Metabolites & Impurities;Pharmaceuticals; C13 to C14; Carbonyl Compounds; Ketones
Melting Point: 87-89 °C(lit.)
Index of Refraction: 1.643
Molar Refractivity: 70.07 cm3
Molar Volume: 193.7 cm3
Polarizability: 27.77×10-24 cm3
Surface Tension: 53.7 dyne/cm
Density: 1.373 g/cm3
Flash Point: 228.1 °C
Enthalpy of Vaporization: 71.3 kJ/mol
Boiling Point: 453.6 °C at 760 mmHg
Vapour Pressure of 2-Amino-2',5-dichlorobenzophenone (CAS NO.2958-36-3): 2.04E-08 mmHg at 25 °C
2-Amino-2',5-dichlorobenzophenone Uses
2-Amino-2',5-dichlorobenzophenone (CAS NO.2958-36-3) is used as Lorazepam Impurity A .
2-Amino-2',5-dichlorobenzophenone Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 56mg/kg (56mg/kg) | U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#04220, |
2-Amino-2',5-dichlorobenzophenone Safety Profile
Hazard Codes: 
Xi, 
Xn
Risk Statements: 36/37/38-20/21/22
R36/37/38:Irritating to eyes, respiratory system and skin.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
Safety Statements: 26-37/39-24/25-36
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S37/39:Wear suitable gloves and eye/face protection.
S24/25:Avoid contact with skin and eyes.
S36:Wear suitable protective clothing.
WGK Germany: 3
RTECS: DJ0200000
Hazard Note of 2-Amino-2',5-dichlorobenzophenone (CAS NO.2958-36-3): Irritant
2-Amino-2',5-dichlorobenzophenone Specification
2-Amino-2',5-dichlorobenzophenone (CAS NO.2958-36-3), its Synonyms are Benzophenone, 2-amino-2',5-dichloro- ; Methanone, (2-amino-5-chlorophenyl)(2-chlorophenyl)- ; (2-Amino-5-chlorophenyl)(2-chlorophenyl)-methanon ; 2-Amino-5,2'-dichlor-benzophenone . It is yellow to yellow-green powder.
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