Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	2-Amino-2-methyl-3-phenylpropionic acid	EINECS	N/A
CAS No.	1132-26-9	Density	1.166 g/cm³
PSA	63.32000	LogP	1.73140
Solubility	slightly soluble in water	Melting Point	293-294 °C (dec.)(lit.)
Formula	C₁₀H₁₃NO₂	Boiling Point	312.8 °C at 760 mmHg
Molecular Weight	179.219	Flash Point	143 °C
Transport Information	N/A	Appearance	white crystalline powder
Safety	22-24/25	Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	2-Methyl-3-phenylalanine;	Article Data	23

2-Amino-2-methyl-3-phenylpropionic acid Synthetic route

: 100-39-0
benzyl bromide

: C16H13N3O3(2-)*Ni(2+)

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
With potassium hydroxide; C-9 In dichloromethane at 20℃;	95%

: 100-39-0
benzyl bromide

: 117470-83-4
ethyl N-<(4-chlorophenyl)methylene>-DL-alanate

A: 1132-26-9
2-methyl-3-phenylalanine

B: 302-72-7
rac-Ala-OH

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 48h; Product distribution; Heating; further alkylation method;	A 94% B 7%

: 100-39-0
benzyl bromide

: 126402-81-1
isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
Stage #1: benzyl bromide; isopropyl 2-[(E)-1-phenylmethylideneamino]propanoate With cesium hydroxide; (R,R)-TADDOL In toluene at 15 - 20℃; for 12h; Alkylation; benzylation; Stage #2: With hydrogenchloride In water; toluene Hydrolysis; Heating;	94%

: 86778-91-8
(+/-)-N-(tert-butoxycarbonyl)-α-methylphenylalanine

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
With hydrogenchloride In tetrahydrofuran for 2h; Ambient temperature;	89%
With ammonium hydroxide; silica gel; trifluoroacetic acid 1.) MeOH; Yield given. Multistep reaction;

: 100-39-0
benzyl bromide

: N-benzylidene-D,L-alanine isopropyl ester

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
Stage #1: benzyl bromide; N-benzylidene-D,L-alanine isopropyl ester With sodium hydroxide; tetraethylammonium bromide; (R,R)-TADDOL In toluene at 15 - 20℃; for 12h; Substitution; Stage #2: With hydrogenchloride In water for 0.25h; Hydrolysis; Further stages.;	83%

: 100-39-0
benzyl bromide

: 69555-16-4
ethyl 2-(diphenylmethyleneamino)propanoate

A: 1132-26-9
2-methyl-3-phenylalanine

B: 302-72-7
rac-Ala-OH

Conditions

Conditions	Yield
With tetrabutylammomium bromide; potassium carbonate In acetonitrile for 48h; Product distribution; Heating; further alkylation method;	A 23% B 63%

: 5874-61-3, 21453-79-2, 51127-19-6, 75658-67-2
4-benzyl-2-phenyl-2-oxazolin-5-one

: 74-88-4
methyl iodide

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
(i) iPr2NEt, (ii) aq. HCl, AcOH; Multistep reaction;

: 64298-85-7
methyl-2-benzylideneamino-2-methyl-3-phenylpropanoate

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
With hydrogenchloride 1.) ether, 12 h, room temp.; 2.) reflux, 4 h; Yield given. Multistep reaction;

: 46438-07-7
α-methyl-α-carbethoxy-β-phenethylamine

A: 1132-26-9
2-methyl-3-phenylalanine

B: 164453-67-2
ethyl (S)-2-amino-2-methyl-3-phenylpropanoate

C: 22435-99-0
ethyl (R)-2-amino-2-methyl-3-phenylpropanoate

Conditions

Conditions	Yield
With phosphate buffer; Humicola amino esterase Ambient temperature; Title compound not separated from byproducts;

: 27993-44-8
5-benzyl-5-methyl-imidazolidine-2,4-dione

: 1132-26-9
2-methyl-3-phenylalanine

Conditions

Conditions	Yield
With sodium hydroxide Heating;

2-Amino-2-methyl-3-phenylpropionic acid Specification

This chemical is called 2-Amino-2-methyl-3-phenylpropionic acid, and its systematic name is α-methylphenylalanine. The CAS registry number is 1132-26-9. In addition, this chemical is white crystalline powder, and it's soluble in 80% acetic acid, slightly soluble in water. However, it should be stored at the temperature of RT.

Other characteristics of the 2-Amino-2-methyl-3-phenylpropionic acid can be summarised as followings: (1)ACD/LogP: 1.46; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -1.03; (4)ACD/LogD (pH 7.4): -1.05; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 3; (10)#H bond donors: 3; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 29.54 Å²; (13)Index of Refraction: 1.566; (14)Molar Refractivity: 50.13 cm³; (15)Molar Volume: 153.6 cm³; (16)Polarizability: 19.87×10^-24cm³; (17)Surface Tension: 50.4 dyne/cm; (18)Density: 1.166 g/cm³; (19)Flash Point: 143 °C; (20)Enthalpy of Vaporization: 58.47 kJ/mol; (21)Boiling Point: 312.8 °C at 760 mmHg; (22)Vapour Pressure: 0.000221 mmHg at 25°C.

Production method of this chemical: The 2-Amino-2-methyl-3-phenylpropionic acid could be obtained by the reactant of (+/-)-N-(tert-butoxycarbonyl)-a-methylphenylalanine. This reaction needs the reagent of aq. HCl, and the solvent of tetrahydrofuran. The yield is 89 %. In addition, this reaction should be taken for 2 hours at the ambient temperature.

Uses of this chemical: The 2-Amino-2-methyl-3-phenylpropionic acid could react with phthalic acid anhydride, and obtain the 2-methyl-3-phenyl-2-phthalimido-propionic acid. The yield is 75 %. In addition, this reaction should be taken for 30 minutes at the temperature of 140 °C.

When you are using this chemical, please be cautious about it as the following: Do not breathe dust. Avoid contacting with skin and eyes.

You can still convert the following datas into molecular structure:
1.SMILES: O=C(O)C(N)(Cc1ccccc1)C
2.InChI: InChI=1/C10H13NO2/c1-10(11,9(12)13)7-8-5-3-2-4-6-8/h2-6H,7,11H2,1H3,(H,12,13)
3.InChIKey: HYOWVAAEQCNGLE-UHFFFAOYAP

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 1132-26-9