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Cas Database |
| Name |
2-Amino-5-chloropyrazine |
EINECS | 689-326-8 |
| CAS No. | 33332-29-5 | Density | 1.438 g/cm3 |
| PSA | 51.80000 | LogP | 1.29340 |
| Solubility | N/A | Melting Point |
122-128℃ |
| Formula | C4H4ClN3 | Boiling Point | 278.45 °C at 760 mmHg |
| Molecular Weight | 129.549 | Flash Point | 122.203 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | 26 | Risk Codes | 22-36 |
| Molecular Structure |
|
Hazard Symbols | Xn |
| Synonyms |
Pyrazinamine,5-chloro- (9CI);Pyrazine, 2-amino-5-chloro- (7CI,8CI);(5-Chloropyrazin-2-yl)amine;5-chloropyrazin-2-amine; |
Article Data | 27 |
2-Amino-5-chloropyrazine Synthetic route
- 5049-61-6
2-Aminopyrazine
- 33332-29-5
2-amino-5-chloropyrazine
| Conditions | Yield |
|---|---|
| With N-chloro-N-methoxybenzenesulfonamide In acetonitrile at 50℃; for 5h; | 80% |
| With N-chloro-N-methoxy-4-methylbenzenesulfonamide In acetonitrile at 40℃; for 4h; Reagent/catalyst; Temperature; | 80% |
| With Selectfluor; lithium chloride In N,N-dimethyl-formamide at 15℃; for 12h; Inert atmosphere; Schlenk technique; Sealed tube; regioselective reaction; | 60% |
- 5049-61-6
2-Aminopyrazine
A
- 6863-73-6
3-chloropyrazin-2-amine
B
- 33332-29-5
2-amino-5-chloropyrazine
C
- 873-42-7
3,5-dichloro-pyrazin-2-ylamine
| Conditions | Yield |
|---|---|
| With N-chloro-succinimide In acetonitrile at 20℃; for 72h; | A n/a B 57% C 13% |
- 475641-50-0
pyridinium N-(3'-bromo-5'-chloropyrazin-2'-yl)aminide
A
- 33332-29-5
2-amino-5-chloropyrazine
| Conditions | Yield |
|---|---|
| With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; potassium carbonate In acetonitrile; benzene at 80℃; for 24h; | A 10% B 52% |
| With 2,2'-azobis(isobutyronitrile); tris-(trimethylsilyl)silane; potassium carbonate In acetonitrile; benzene at 80℃; for 24h; | A 10% B 52% |
| Conditions | Yield |
|---|---|
| With N-chloro-succinimide In chloroform for 2h; Product distribution / selectivity; Heating / reflux; | A 4% B 14% |
- 6863-77-0
3-aminopyrazine 1-oxide
A
- 6863-73-6
3-chloropyrazin-2-amine
B
- 33332-29-5
2-amino-5-chloropyrazine
C
- 33332-28-4
2-amino-6-chloropyrazine
| Conditions | Yield |
|---|---|
| With trichlorophosphate for 2h; Heating; Yield given. Yields of byproduct given. Title compound not separated from byproducts; | |
| With trichlorophosphate for 2h; Product distribution; Mechanism; Heating; other substituted pyrazine-1-oxides and products, deoxygenation/chlorination competition; other time; |
- 1458-03-3
3-amino-6-chloropyrazine-2-carboxylic acid methyl ester
- 33332-29-5
2-amino-5-chloropyrazine
| Conditions | Yield |
|---|---|
| With sodium hydroxide In diphenylether; water |
- 5424-01-1
3-aminopyrazinoic acid
- 16298-03-6
Methyl 3-amino-2-pyrazinecarboxylate
- 20667-76-9, 20667-77-0, 21124-13-0
1-methyl-3-(4-methylphenyl)-triazene
- 33332-29-5
2-amino-5-chloropyrazine
| Conditions | Yield |
|---|---|
| In tetrahydrofuran; diethyl ether; water; acetic acid |
- 33332-29-5
2-amino-5-chloropyrazine
| Conditions | Yield |
|---|---|
| With tetrafluoroboric acid; sodium nitrite In water at 0 - 20℃; for 4h; Inert atmosphere; | 93% |
- 541-41-3
chloroformic acid ethyl ester
- 33332-29-5
2-amino-5-chloropyrazine
- 1419610-84-6
ethyl (5-chloropyrazin-2-yl)carbamate
| Conditions | Yield |
|---|---|
| With pyridine at 20℃; for 0.5h; | 91% |
| Conditions | Yield |
|---|---|
| With potassium carbonate In ethanol; water at 80℃; for 8h; Suzuki-Miyaura coupling reaction; Inert atmosphere; | 90% |
2-Amino-5-chloropyrazine Chemical Properties
Molecular Structure of 2-Amino-5-chloropyrazine (CAS NO.33332-29-5):
.png)
IUPAC Name: 5-chloropyrazin-2-amine
Empirical Formula: C4H4ClN3
Molecular Weight: 129.5477
CAS Registry Number: 33332-29-5
ACD/LogP: 0.79
of Rule of 5 Violations: 0
ACD/LogD (pH 5.5): 1
ACD/LogD (pH 7.4): 1
ACD/BCF (pH 5.5): 6
ACD/BCF (pH 7.4): 6
ACD/KOC (pH 5.5): 120
ACD/KOC (pH 7.4): 120
H bond acceptors: 3
H bond donors: 2
Freely Rotating Bonds: 0
Polar Surface Area: 51.8 ?2
Index of Refraction: 1.618
Surface Tension: 66.442 dyne/cm
Density: 1.438 g/cm3
Flash Point: 122.203 °C
Enthalpy of Vaporization: 51.707 kJ/mol
Boiling Point: 278.45 °C at 760 mmHg
Vapour Pressure: 0.004 mmHg at 25°C
Product Categories: Amines and Anilines; Heterocycles; Piperazine series; API intermediates; Pyrazine
2-Amino-5-chloropyrazine Specification
2-Amino-5-chloropyrazine , its cas register number is 33332-29-5. It also can be called 2-amino-5-chloropyrazine 98% ; 2-amino-5-chloropyrazine 98+% ; 5-chloropyrazin-2-amine ; Pyrazinamine,5-chloro- (9CI) ; Pyrazine, 2-amino-5-chloro- (7CI,8CI) ; (5-Chloropyrazin-2-yl)amine .
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