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Cas Database |
| Name |
2-Bromo-2-(2'-chlorophenyl) acetic acid |
EINECS | N/A |
| CAS No. | 29270-30-2 | Density | 1.747 g/cm3 |
| PSA | 37.30000 | LogP | 2.86060 |
| Solubility | N/A | Melting Point |
105-108 °C |
| Formula | C8H6BrClO2 | Boiling Point | 316.7 °C at 760 mmHg |
| Molecular Weight | 249.491 | Flash Point | 145.3 °C |
| Transport Information | UN 3261 | Appearance | N/A |
| Safety | 24/25 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 C
|
| Synonyms |
A-BROMO 2-CHLOROPHENYLACETIC ACID;alpha-Bromo-2-chlorobenzeneacetic acid;2-BROMO-2-(2-CHLOROPHENYL) ACETIC ACID;à-bromo-2-chlorophenylacetic acid;A-BROMO-2-CHLOROBENZENEACETIC ACID;L-ALPHA-BROMO-(2-CHLORO)PHENYL ACETIC ACID;α-Bromo-2-chlorobenzeneacetic acid;ɑ-Bromo-2-chlorophenylacetic acid, 98% |
Article Data | 12 |
2-Bromo-2-(2'-chlorophenyl) acetic acid Synthetic route
- 2444-36-2
2'-chloro-benzeneacetic acid
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
| Conditions | Yield |
|---|---|
| With sulfuric acid; dihydrogen peroxide; sodium bromide In dichloromethane; water at 10 - 30℃; for 40h; Time; Large scale; | 89% |
| With N-Bromosuccinimide; dibenzoyl peroxide In tetrachloromethane at 80℃; for 5h; | 48% |
| With N-Bromosuccinimide In tetrachloromethane | |
| With N-Bromosuccinimide | |
| With sulfuric acid; dihydrogen peroxide; sodium bromide In dichloromethane at 25℃; for 24h; Reagent/catalyst; Solvent; Irradiation; |
- 86169-24-6, 141196-64-7, 141315-50-6, 88744-36-9
2-amino-(2-chlorophenyl)ethanoic acid
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
| Conditions | Yield |
|---|---|
| With hydrogen bromide; sodium nitrite In water at 0℃; for 7.33333h; | 73% |
| Stage #1: 2-amino-(2-chlorophenyl)ethanoic acid With hydrogen bromide In water at 0℃; for 0.166667h; Stage #2: With sodium nitrite In water at 0 - 20℃; for 3.5h; |
| Conditions | Yield |
|---|---|
| With hydrogenchloride; potassium hydroxide In 1,2-dimethoxyethane; water; toluene | 67% |
| Stage #1: Bromoform; 2-chloro-benzaldehyde With potassium hydroxide In 1,2-dimethoxyethane; water at -5 - 10℃; for 13h; Stage #2: With hydrogenchloride In dichloromethane; water |
- 10421-85-9, 52923-23-6, 52950-18-2, 52950-19-3
2-chloromandelic acid
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
| Conditions | Yield |
|---|---|
| With hydrogen bromide at 120℃; unter Druck; |
- 2444-36-2
2'-chloro-benzeneacetic acid
A
- 29270-33-5
2-bromo-2-(4-fluorophenyl)acetic acid
B
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
- 75-25-2
Bromoform
- 108-20-3
di-isopropyl ether
- 89-98-5
2-chloro-benzaldehyde
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
| Conditions | Yield |
|---|---|
| With hydrogenchloride; potassium hydroxide In 1,4-dioxane; water; toluene |
- 67-56-1
methanol
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
- 85259-19-4
methyl 2-bromo-2-(2-chlorophenyl)acetate
| Conditions | Yield |
|---|---|
| With sulfuric acid for 3h; Reflux; | 95.07% |
| With sulfuric acid at 25 - 66℃; | 93% |
| With sulfuric acid at 75℃; Time; Large scale; | 90% |
- 54903-50-3
4,5,6,7-tetrahydrothieno[3,2-c]pyridine
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
- 90055-55-3
2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid
| Conditions | Yield |
|---|---|
| In acetonitrile at 20℃; | 91% |
| With triethylamine In dichloromethane for 5h; Product distribution / selectivity; Heating / reflux; | 78% |
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
- 28783-41-7
6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride
- 90055-55-3
2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridine-5(4H)-yl)acetic acid
| Conditions | Yield |
|---|---|
| Stage #1: α-bromo-2-chlorophenyl acetic acid; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium hydroxide In methanol; water at 10 - 40℃; for 3h; Stage #2: With hydrogenchloride In methanol; water at 5 - 20℃; for 4h; pH=3.5; | 88% |
| Stage #1: α-bromo-2-chlorophenyl acetic acid; 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With potassium hydroxide In methanol; water at 15 - 40℃; for 3h; Stage #2: With hydrogenchloride In methanol; water at 20℃; for 2h; pH=3.5; | 88% |
| Stage #1: 6,7-dihydro-4H-thieno[3,2-c]pyridine hydrochloride With sodium hydroxide In water at 20 - 35℃; Stage #2: α-bromo-2-chlorophenyl acetic acid In water at 20 - 27℃; Stage #3: With hydrogenchloride In water; ethyl acetate at 20 - 30℃; pH=3.5 - 4.5; | |
| With potassium hydroxide In water at 0 - 20℃; for 24h; | 12 g |
- 29270-30-2
α-bromo-2-chlorophenyl acetic acid
- 18107-18-1
diazomethyl-trimethyl-silane
- 85259-19-4
methyl 2-bromo-2-(2-chlorophenyl)acetate
| Conditions | Yield |
|---|---|
| In methanol; toluene for 0.25h; Inert atmosphere; Cooling in water bath; | 86% |
2-Bromo-2-(2'-chlorophenyl) acetic acid Chemical Properties
Molecular Structure of 2-Bromo-2-(2'-chlorophenyl) acetic acid (CAS NO.29270-30-2):
IUPAC: Bromo(2-chlorophenyl)acetic acid
Molecular Formula: C8H6BrClO2
Molecular Weight: 249.49
Product Categories: Pharmaceutical Intermediates
Melting Point: 105-108oC
Density: 1.747 g/cm3
Flash Point: 145.3oC
Boiling Point: 316.7oC at 760 mmHg
Index of Refraction: 1.617
Molar Volume: 142.7 cm3
Surface Tension: 57 dyne/cm
Molar Refractivity: 49.99 cm3
Enthalpy of Vaporization: 58.92 kJ/mol
Vapour Pressure: 0.00017 mmHg at 25oC
SMILES: Clc1ccccc1C(Br)C(=O)O
InChI: InChI=1/C8H6BrClO2/c9-7(8(11)12)5-3-1-2-4-6(5)10/h1-4,7H,(H,11,12)
2-Bromo-2-(2'-chlorophenyl) acetic acid Safety Profile
Safety Information of 2-Bromo-2-(2'-chlorophenyl) acetic acid (CAS NO.29270-30-2):
Hazard Codes: C
Safety Statements: 24/25
S24/25:Avoid contact with skin and eyes.
RIDADR: UN3261
Hazard Note: Corrosive
HazardClass: 8
PackingGroup: II
2-Bromo-2-(2'-chlorophenyl) acetic acid Specification
2-Bromo-2',4'-dichloroacetophenone with cas registry number of 29270-30-2 is also known as Benzeneacetic acid, alpha-bromo-2-chloro- ; Bromo(2-chlorophenyl)acetic acid ; A-bromo 2-chlorophenylacetic acid ; Alpha-bromo-2-chlorophenylacetic acid . It should be stored in a dry,cool place in tightly closed containers . 2-Bromo-2',4'-dichloroacetophenone with cas registry number of 29270-30-2 is used as a pharmaceutical intermediate .
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