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2-Chloro-4'-hydroxyacetophenone
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Name

2-Chloro-4'-hydroxyacetophenone

 EINECS 228-613-0
CAS No. 6305-04-0 Density 1.304 g/cm3
PSA 37.30000 LogP 1.81370
Solubility N/A Melting Point 145-146 °C
Formula C8H7 Cl O2 Boiling Point 337.1 ºC at 760 mmHg
Molecular Weight 170.595 Flash Point 157.7 ºC
Transport Information N/A Appearance N/A
Safety A poison by ingestion. A severe skin and eye irritant. When heated to decomposition it emits toxic vapors of Cl−. Risk Codes N/A
Molecular Structure Molecular Structure of 6305-04-0 (2-CHLORO-4'-HYDROXYACETOPHENONE) Hazard Symbols N/A
Synonyms

Acetophenone,2-chloro-4'-hydroxy- (6CI,7CI); 2-Chloro-1-(4-hydroxyphenyl)ethanone;2-Chloro-4'-hydroxyacetophenone; 4-Hydroxy-a-chloroacetophenone; 4-Hydroxyphenacyl chloride;4'-Hydroxy-2-chloroacetophenone; Chlorophenacyle; NSC 41671;p-(Chloroacetyl)phenol; p-Hydroxyphenacyl chloride; w-Chloro-4-hydroxyacetophenone

Article Data 24

2-Chloro-4'-hydroxyacetophenone Synthetic route

99-93-4

4-Hydroxyacetophenone

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate In methanol; 1,2-dichloro-ethane for 10h; Heating;95%
With 2,2,3,4,5,6-hexachloro-cyclohexa-2,4-dien-1-one In ethanol for 5h; Heating;77%
With hydrogenchloride; ammonium nitrate; iodine; oxygen In water; acetonitrile at 60℃; for 22h; Green chemistry; chemoselective reaction;64%
With N-chloro-succinimide; toluene-4-sulfonic acid In acetonitrile at 40℃;45%
79-04-9

chloroacetyl chloride

108-95-2

phenol

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With aluminum (III) chloride In dichloromethane at 0 - 30℃; for 7h; Solvent;94%
With aluminium trichloride In various solvent(s) at 70℃; for 5h;50%
Stage #1: chloroacetyl chloride; phenol; aluminum (III) chloride In 1,2-dichloro-ethane at 0 - 65℃; for 13h;
Stage #2: With hydrogenchloride In dichloromethane; water		15%
868746-76-3

2-chloro-1-(4-chloroacetoxy-phenyl)-ethanone

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 0 - 20℃; for 0.5h;85%
620-73-5

phenyl chloroacetate

A

53074-73-0

2-(2-chloroacetyl)phenol

B

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With beryllium(II) chloride at 130 - 140℃;
With aluminium trichloride at 120℃;
620-73-5

phenyl chloroacetate

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With aluminium trichloride
100-66-3

methoxybenzene

79-04-9

chloroacetyl chloride

A

53074-73-0

2-(2-chloroacetyl)phenol

B

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With aluminium trichloride; 1,1,2,2-tetrachloroethane
With aluminium trichloride; 1,1,2,2-tetrachloroethane
100-66-3

methoxybenzene

79-04-9

chloroacetyl chloride

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
With aluminium trichloride; Petroleum ether
With aluminium trichloride
With carbon disulfide; aluminium trichloride
With aluminium trichloride

Dimethyl-<4-hydroxy-phenacyl>-sulfoniumchlorid

6305-04-0

p-hydroxyphenacyl chloride

Conditions
ConditionsYield
at 110℃;
620-73-5

phenyl chloroacetate

7446-70-0

aluminium trichloride

A

6305-04-0

p-hydroxyphenacyl chloride

B

ω-chloro-2-oxy-acetophenone

ω-chloro-2-oxy-acetophenone

Conditions
ConditionsYield
at 120℃;
620-73-5

phenyl chloroacetate

A

6305-04-0

p-hydroxyphenacyl chloride

B

ω-chloro-2-oxy-acetophenone

ω-chloro-2-oxy-acetophenone

Conditions
ConditionsYield
With aluminium trichloride at 120℃;

2-Chloro-4'-hydroxyacetophenone Chemical Properties

IUPAC Name: 2-Chlor-1-(4-hydroxyphenyl)ethanon
The MF of 2-Chlor-1-(4-hydroxyphenyl)ethanon (6305-04-0) is C8H7ClO2.

                                     
The MW of 2-Chlor-1-(4-hydroxyphenyl)ethanon (6305-04-0) is 170.59298.
Synonyms of 2-Chlor-1-(4-hydroxyphenyl)ethanon (6305-04-0): 2-Chloro-1-(4-hydroxyphenyl)ethanone ; Ethanone, 2-chloro-1- (4-hydroxyphenyl)- ; 2-Chloro-1-(4-hydroxyphenyl)ethan-1-one ; 2-Chloro-4'-hydroxyacetophenone
Index of Refraction: 1.571  
EINECS: 228-613-0
Density: 1.304 g/ml
Flash Point: 157.7 °C
Boiling Point: 337.1 °C

2-Chloro-4'-hydroxyacetophenone Toxicity Data With Reference

1.    

skn-rbt 500 mg SEV

     JACTDZ    Journal of the American College of Toxicology. 12 (1993),581.
2.    

eye-rbt 10 mg SEV

     JACTDZ    Journal of the American College of Toxicology. 12 (1993),581.
3.    

orl-rat LD50:230 mg/kg

     JACTDZ    Journal of the American College of Toxicology. 12 (1993),581.
4.    

skn-rbt LD50:>8 g/kg

     JACTDZ    Journal of the American College of Toxicology. 12 (1993),581.

2-Chloro-4'-hydroxyacetophenone Safety Profile

A poison by ingestion. A severe skin and eye irritant. When heated to decomposition it emits toxic vapors of Cl−.

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