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Cas Database |
| Name |
2-Demethylcolchicine |
EINECS | N/A |
| CAS No. | 7336-36-9 | Density | 1.31g/cm3 |
| PSA | 94.09000 | LogP | 2.95950 |
| Solubility | N/A | Melting Point |
125°C |
| Formula | C21H24NO6 | Boiling Point | 766.1°Cat760mmHg |
| Molecular Weight | 385.417 | Flash Point | 417.1°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion, intramuscular, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
O2-Demethylcolchicin;2-O-demethylcolchicine;3-demethylcolchicine; |
Article Data | 7 |
2-Demethylcolchicine Chemical Properties
Product Name: 2-Demethylcolchicine (CAS NO.7336-36-9)
IUPAC: N-[(7S)-2-hydroxy-1,3,10-trimethoxy-9-oxo-6,7-dihydro- 5H-benzo[a]heptalen-7-yl]acetamide
Molecular Formula: C21H23NO6
Molecular Weight: 385.41g/mol
Mol File: 7336-36-9.mol
Boiling point: 766.1 °C at 760 mmHg
Flash Point: 417.1 °C
Density: 1.31 g/cm3
Surface Tension: 56.7 dyne/cm
Enthalpy of Vaporization: 115.46 kJ/mol
Vapour Pressure: 2.63E-24 mmHg at 25°C
XLogP3-AA: 0.5
H-Bond Donor: 2
H-Bond Acceptor: 6
2-Demethylcolchicine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intramuscular | 16577ug/kg (16.577mg/kg) | Journal of Medicinal Chemistry. Vol. 24, Pg. 257, 1981. | |
| mouse | LD50 | intraperitoneal | 16mg/kg (16mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957. |
| mouse | LD50 | oral | 19mg/kg (19mg/kg) | BEHAVIORAL: FOOD INTAKE (ANIMAL) BEHAVIORAL: MUSCLE WEAKNESS GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 94, Pg. 453, 1953. |
| rat | LDLo | intracrebral | 75ug/kg (0.075mg/kg) | BEHAVIORAL: TREMOR BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD BEHAVIORAL: EXCITEMENT | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 109, Pg. 386, 1957. |
2-Demethylcolchicine Safety Profile
Poison by ingestion, intramuscular, intracerebral, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of NOx.
2-Demethylcolchicine Specification
2-Demethylcolchicine , its CAS NO. is 7336-36-9, the synonyms are Alkaloid CC 6, from Colchicum cornigerum ; NSC 180533 ; O(sup 2)-Demethylcolchicine ; Acetamide, N-(5,6,7,9-tetrahydro-2-hydroxy-1,3,10-trimethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)- (9CI) ; Colchicine, 3-demethyl- (7CI) ; Colchicine, O(2)-demethyl- (8CI) ; Colchicine, O(sup 2)-demethyl- .
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