Basic Information | Post buying leads | Suppliers | Cas Database |
Name |
3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one |
EINECS | N/A |
CAS No. | 79098-75-2 | Density | 1.18 g/cm3 |
PSA | 44.37000 | LogP | 2.19080 |
Solubility | N/A | Melting Point |
N/A |
Formula | C13H17N3O | Boiling Point | 459.008 °C at 760 mmHg |
Molecular Weight | 231.297 | Flash Point | 231.4 °C |
Transport Information | N/A | Appearance | N/A |
Safety | Risk Codes | N/A | |
Molecular Structure | Hazard Symbols | N/A | |
Synonyms |
3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one;3-Piperidin-4-yl-3,4-dihydro-1H-quinazolin-2-one; |
Article Data | 7 |
1-benzyl-4-(1,2,3,4-tetrahydro-2-oxo-3-quinazolinyl)piperidine
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
With palladium 10% on activated carbon; hydrogen In methanol for 48h; | 100% |
With hydrogen; Pd/C In ethanol at 60℃; under 1500.15 Torr; | 85% |
With hydrogen; palladium on activated charcoal In ethanol at 60℃; under 1500.15 Torr; | 85% |
tert-butyl 4-(2-oxo-1,2,3,4-tetrahydroquinazolin-3-yl)piperidine-1-carboxylate
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
With trifluoroacetic acid In dichloromethane at 20℃; | 92% |
2-nitro-benzaldehyde
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; methanol 2: hydrogen / palladium on activated charcoal / ethanol 3: acetonitrile / Reflux View Scheme |
4-amino-1-benzylpiperidine
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: sodium tetrahydroborate; methanol 2: hydrogen / palladium on activated charcoal / ethanol 3: acetonitrile / Reflux View Scheme | |
Multi-step reaction with 5 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C 2: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C 3: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 4: tetrahydrofuran / 5 h / 20 °C 5: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme |
2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine
1,1'-carbonyldiimidazole
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Stage #1: 2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine; 1,1'-carbonyldiimidazole In acetonitrile Reflux; Stage #2: With hydrogen; palladium(II) hydroxide In methanol |
(1-benzyl-piperidin-4-yl)-(2-nitro-benzyl)-amine
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrogen / palladium on activated charcoal / ethanol 2: acetonitrile / Reflux View Scheme |
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 4 steps 1: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C 2: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 3: tetrahydrofuran / 5 h / 20 °C 4: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme |
2-amino-N-(1-benzyl-piperidin-4-yl)-benzamide
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 2: tetrahydrofuran / 5 h / 20 °C 3: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme |
2-amino-N-[1-(phenylmethyl)-4-piperidinyl]-benzenemethanamine
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: tetrahydrofuran / 5 h / 20 °C 2: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme |
2-(tert-butyloxycarbonylamino)benzoic acid
3-piperidin-4-yl-3,4-dihydro-1H-quinazoline-2-one
Conditions | Yield |
---|---|
Multi-step reaction with 5 steps 1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / N,N-dimethyl-formamide / 5 h / 70 °C 2: trifluoroacetic acid / dichloromethane / 20 h / 0 - 20 °C 3: lithium aluminium tetrahydride / 1,4-dioxane / 3 h / Reflux 4: tetrahydrofuran / 5 h / 20 °C 5: hydrogen; palladium 10% on activated carbon / methanol / 48 h View Scheme |
The 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one, its cas register number is 79098-75-2. It also can be called as 2(1H)-Quinazolinone,3,4-dihydro-3-(4-piperidinyl)- and the Systematic name about this chemical is 3-piperidin-4-yl-3,4-dihydroquinazolin-2(1H)-one.
Following are the chemical properties about 3-(Piperidin-4-yl)-3,4-dihydroquinazolin-2(1H)-one: (1)#H bond acceptors: 4; (2)#H bond donors: 2; (3)#Freely Rotating Bonds: 1; (4)Polar Surface Area: 44.37Å2; (5)Index of Refraction: 1.581; (6)Molar Refractivity: 65.311 cm3; (7)Molar Volume: 195.993 cm3; (8)Polarizability: 25.891x10-24cm3; (9)Surface Tension: 45.599 dyne/cm; (10) Enthalpy of Vaporization: 71.942 kJ/mol; (11)Boiling Point: 459.008 °C at 760 mmHg
This chemical can be described computed from structure:
(1)SMILES:O=C2N(Cc1ccccc1N2)C3CCNCC3
(2)InChI: InChI=1/C13H17N3O/c17-13-15-12-4-2-1-3-10(12)9-16(13)11-5-7-14-8-6-11/h1-4,11,14H,5-9H2,(H,15,17)
(3)InChIKey: KSTFHYBYFDYWSD-UHFFFAOYAK
(4)Std. InChI: InChI=1S/C13H17N3O/c17-13-15-12-4-2-1-3-10(12)9-16(13)11-5-7-14-8-6-11/h1-4,11,14H,5-9H2,(H,15,17)
(5)Std. InChIKey: KSTFHYBYFDYWSD-UHFFFAOYSA-N