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Cas Database |
| Name |
3',5'-Dichloromethotrexate |
EINECS | N/A |
| CAS No. | 528-74-5 | Density | 1.637g/cm3 |
| PSA | 210.54000 | LogP | 3.12850 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | C20H20 Cl2 N8 O5 | Boiling Point | N/A |
| Molecular Weight | 523.335 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Moderately toxic by intraperitoneal and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl−. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
Glutamicacid, N-[3,5-dichloro-4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-(6CI,7CI); Glutamic acid,N-[3,5-dichloro-4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L-(8CI); 3,5-Dichloromethotrexate; 3',5'-Dichloroamethopterin;3',5'-Dichloromethotrexate; Dichloromethotrexate; Methotrexate, dichloro-; NSC145883; NSC 29630 |
Article Data | 3 |
3',5'-Dichloromethotrexate Chemical Properties
Chemistry informtion about 3',5'-Dichloromethotrexate (CAS NO.528-74-5) is:
IUPAC Name: (2S)-2-[[3,5-Dichloro-4-[(2,4-Diaminopteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid ; 2-[[3,5-Dichloro-4-[(2,4-Diaminopteridin-6-Yl)Methyl-Methylamino]Benzoyl]Amino]Pentanedioic Acid
Synonyms: Dichloromethotrexate ; 3',5'-Dichloromethotrexate ; 3',5'-Dichloroaminopterin ; Nci-C-04875 ; Nsc 29630 ; Nsc-29630
MF: C20H20Cl2N8O5
MW: 523.329400 g/mol
Density: 1.637 g/cm3
Following is the molecular structure of 3',5'-Dichloromethotrexate (CAS NO.528-74-5) is:
3',5'-Dichloromethotrexate Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intraperitoneal | 655mg/kg (655mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
| mouse | LD50 | intravenous | 1021mg/kg (1021mg/kg) | behavioral: excitement behavioral: muscle weakness behavioral: ataxia | National Technical Information Service. Vol. PB82-172644, |
| rat | LD50 | unreported | 3130ug/kg (3.13mg/kg) | United States Patent Document. Vol. #4746662, |
3',5'-Dichloromethotrexate Consensus Reports
NCI Carcinogenesis Studies (ipr): Equivocal Evidence: rat; No Evidence: mouse CANCAR Cancer. 40 (1977),1935. .
3',5'-Dichloromethotrexate Safety Profile
Moderately toxic by intraperitoneal and intravenous routes. Questionable carcinogen with experimental tumorigenic data. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and Cl−.
3',5'-Dichloromethotrexate Specification
3',5'-Dichloromethotrexate (CAS NO.528-74-5) is a light yellow or yellow powder.It insoluble in water.When heated to decomposition,it emits toxic fumes.It is probably combustible.
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