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3,5,6-Trichloro-2-pyridinol

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Name

3,5,6-Trichloro-2-pyridinol

EINECS 229-405-2
CAS No. 6515-38-4 Density 1.67 g/cm3
PSA 32.86000 LogP 2.33510
Solubility 0.22g/L(temperature not stated) Melting Point 328-330 °C
Formula C5H2Cl3NO Boiling Point 254.8 °C at 760 mmHg
Molecular Weight 198.436 Flash Point 107.9 °C
Transport Information UN 3077 Appearance powder
Safety 26-39-61 Risk Codes 22-41-51/53
Molecular Structure Molecular Structure of 6515-38-4 (3,5,6-Trichloro-2-pyridinol) Hazard Symbols HarmfulXn, DangerousN
Synonyms

2(1H)-Pyridone,3,5,6-trichloro- (8CI);2-Pyridinol, 3,5,6-trichloro- (7CI);2,3,5-Trichloro-6-hydroxypyridine;2-Hydroxy-3,5,6-trichloropyridine;2-Hydroxyl-3,5,6-trichloropyridine;3,5,6-Trichloro-2-hydroxypyridine;3,5,6-Trichloro-2-pyridinol;3,5,6-Trichloropyridine-2-ol;

Article Data 33

3,5,6-Trichloro-2-pyridinol Synthetic route

3,3,5,6-tetrachloro-1,2,3,4-tetrahydropyridin-2-one

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With sodium hydroxide In 1,2-dichloro-ethane at 25℃; for 20h;100%

sodium salt of 3,5,6-trichloropyridine-2-ol

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With hydrogenchloride In water at 60 - 70℃; for 0.166667h; pH=2 - 3;97.75%
2921-88-2

Chlorpyrifos

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With potassium hydroxide In ethanol for 4h; Heating;91.7%
With potassium hydroxide In ethanol for 1h; Heating;90%
With water at 40℃; for 960h; Rate constant; Thermodynamic data; E(a); other natural water, pH = 8.0;
2402-79-1

2,3,5,6-tetrachloropyridine

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With potassium hydroxide In tert-butyl alcohol for 10h; Heating;88%
With tetrabutylammomium bromide; sodium hydroxide In water at 100℃; for 8h; Inert atmosphere;87%
Stage #1: 2,3,5,6-tetrachloropyridine With potassium hydroxide In water at 95℃; for 0.5h; pH=9.5 - 10;
Stage #2: With benzyltrimethylammonium chloride In water at 120℃; for 4h; Reagent/catalyst; Temperature; Autoclave;
35.9 g
107-13-1

acrylonitrile

76-02-8

Trichloroacetyl chloride

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
Stage #1: acrylonitrile; trifluoroacetyl chloride With copper(l) chloride at 120 - 150℃; under 1140.08 - 4560.31 Torr; for 6h;
Stage #2: With water; sodium hydroxide at 30 - 150℃; under 1520.1 Torr;
61%
16879-02-0

6-chloro-2-hydroxypyridine

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With hydrogenchloride; water; dihydrogen peroxide
856850-90-3

2-ethoxy-6-bromo-3,5-dichloro-pyridine

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With hydrogenchloride; water at 160℃; Unter Druck;
5598-13-0

O,O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate

6515-38-4

3,5,6-trichloropyridin-2 ol

Conditions
ConditionsYield
With sodium phosphate buffer; hydrogen sulfide; sodium chloride In methanol at 25℃; pH=5.9; Kinetics; Further Variations:; pH-values; var. hydrogen sulfide concentration;
With C54H36N6NiO10S2 In aq. phosphate buffer at 30℃; for 0.833333h;
5598-52-7

Fospirate

A

6515-38-4

3,5,6-trichloropyridin-2 ol

B

813-78-5

dimethylphosphoric acid

Conditions
ConditionsYield
With bacterial phosphotriesterase wild-type OpdA In methanol at 37℃; pH=8.5; Enzyme kinetics;
With air In acetonitrile for 3.91667h; Kinetics; Solvent; UV-irradiation;
5598-13-0

O,O-dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate

A

6515-38-4

3,5,6-trichloropyridin-2 ol

B

1112-38-5

dimethylthiophosphoric acid

Conditions
ConditionsYield
With bacterial phosphotriesterase wild-type OpdA In methanol at 37℃; pH=8.5; Enzyme kinetics;
With water; sodium hydroxide In acetonitrile at 25℃; for 6h; Kinetics; Mechanism; Equilibrium constant; Solvent; Concentration; Reagent/catalyst; pH-value;

3,5,6-Trichloro-2-pyridinol Chemical Properties

IUPAC Name: 3,5,6-Trichloro-2-pyridinol
The MF of 3,5,6-Trichloro-2-pyridinol (6515-38-4) is C5H2Cl3NO.

                                  
The MW of 3,5,6-Trichloro-2-pyridinol (6515-38-4) is 198.43.
Synonyms of 3,5,6-Trichloro-2-pyridinol (6515-38-4): 2(1H)-Pyridinone, 3,5,6-trichloro- ; 2-Pyridinol, 3,5,6-trichloro- ; 3,5,6-Trichloro-2-hydroxypyridine ; 3,5,6-Trichloro-2-pyridinol ; 3,5,6-Trichloropyridin-2-ol ; Chlorpyrifos metabolite
Product Categories: Pyridines;Q-ZAlphabetic;TP - TZ;Alpha sort;Environmental Standards;MetabolitesPesticides&Metabolites;Pesticides&Metabolites
Stability: Stable. Incompatible with strong oxidizing agents
Index of Refraction: 1.598 
EINECS: 229-405-2
Density: 1.67 g/ml 
Flash Point: 107.9 °C
Boiling Point: 254.8 °C
Melting Point: 328-330°C
Form: powder

3,5,6-Trichloro-2-pyridinol Uses

   3,5,6-Trichloro-2-pyridinol (6515-38-4) is used as PVC and three acetate (film film film-based) and other plasticizers.

3,5,6-Trichloro-2-pyridinol Toxicity Data With Reference

1.    

orl-rat LD50:800 mg/kg

    TOSCF2    Toxicological Sciences 53 (2000),100.
2.    

skn-rbt LD50:>2 g/kg

    TOSCF2    Toxicological Sciences 53 (2000),100.

3,5,6-Trichloro-2-pyridinol Safety Profile

Moderately toxic by ingestion and skin contact. Experimental reproductive effects. When heated to decomposition it emits toxic vapors of NOx and Cl.
Safety information of 3,5,6-Trichloro-2-pyridinol (6515-38-4):
Hazard Codes  Xn;N
Risk Statements 
22  Harmful if swallowed
41  Risk of serious damage to eyes
51/53  Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment 
Safety Statements 
26  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
39  Wear eye/face protection
61  Avoid release to the environment. Refer to special instructions safety data sheet
RIDADR  UN 3077
RTECS  UU7786700

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