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Name	3-Boc-amino-2,6-dioxopiperidine	EINECS	N/A
CAS No.	31140-42-8	Density	1.2 g/cm³
PSA	84.50000	LogP	1.03600
Solubility	N/A	Melting Point	193.7-194.4 °C
Formula	C₁₀H₁₆N₂O₄	Boiling Point	423 °C at 760 mmHg
Molecular Weight	228.248	Flash Point	209.6 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	N/A
Molecular Structure		Hazard Symbols	N/A
Synonyms	2,6-Dioxo-3-piperidinecarbamic acid tert-butyl ester;carbamic acid, N-(2,6-dioxo-3-piperidinyl)-, 1,1-dimethylethyl ester;	Article Data	26

3-Boc-amino-2,6-dioxopiperidine Synthetic route

: 85535-45-1
5-amino-2-(tert-butoxycarbonylamino)-5-oxo-pentanoic acid

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dicyclohexyl-carbodiimide In N,N-dimethyl-formamide at 80℃;	99%
With dmap; triethylamine; 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; for 72h;	90%
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 16h; Reflux;	88%

: 120341-33-5
1-[(tert-butoxy)-carbonyl-amino]propane-1,3-dicarboxylic acid

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 2,2,2-trifluoroacetamide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine at 20℃;	95%
With 2,2,2-trifluoroacetamide; TEA; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide In dichloromethane

: 24424-99-5
di-tert-butyl dicarbonate

: 24666-56-6
rac-α-aminoglutarimide hydrochloride

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Stage #1: rac-α-aminoglutarimide hydrochloride With triethylamine In dichloromethane at 50℃; for 0.5h; Sealed tube; Microwave irradiation; Stage #2: di-tert-butyl dicarbonate In dichloromethane at 0℃; for 0.5h;	87%

: 13726-85-7
Boc-Gln-OH

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 17h; Heating;	76%
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 24h; Heating;	76%
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran at 20℃; Inert atmosphere; Reflux;	76%

: Boc-glutamine methyl ester

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With 1-hydroxy-pyrrolidine-2,5-dione; diisopropyl-carbodiimide In tetrahydrofuran for 48h; Reflux;	66.2%

: 4976-88-9
(S)-methyl 5-amino-2-(tert-butoxycarbonylamino)-5-oxopentanoate

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With dmap; 1,1'-carbonyldiimidazole In tetrahydrofuran for 48h; Reflux;	64%

: 24424-99-5
di-tert-butyl dicarbonate

: 3-aminopiperidine-2,6-dione hydrochloric acid salt

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 8h;	58%

: 1218991-05-9
glutamine methyl ester

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: sodium hydrogencarbonate / water; methanol / 15 h / 20 °C 2: diisopropyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / tetrahydrofuran / 48 h / Reflux View Scheme

: 56-85-9, 585-21-7, 5959-95-5, 6899-04-3
GLUTAMINE

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

Conditions

Conditions	Yield
Multi-step reaction with 3 steps 1: thionyl chloride / 8 h / 0 °C / Reflux 2: sodium hydrogencarbonate / water; methanol / 15 h / 20 °C 3: diisopropyl-carbodiimide; 1-hydroxy-pyrrolidine-2,5-dione / tetrahydrofuran / 48 h / Reflux View Scheme

: 31140-42-8
(RS)-(2,6-dioxopiperidin-3-yl)carbamic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: (RS)-2,6-dioxopiperidin-3-yl-ammonium trifluoroacetate

Conditions

Conditions	Yield
at 20℃; for 0.5h;	100%
In dichloromethane at 25℃;	99%
In dichloromethane at 20℃; for 4h;	98%

3-Boc-amino-2,6-dioxopiperidine Specification

The CAS register number of 3-Boc-amino-2,6-dioxopiperidine is 31140-42-8. It also can be called as 2,6-Dioxo-3-piperidinecarbamic acid tert-butyl ester and the IUPAC name about this chemical is tert-butyl N-(2,6-dioxopiperidin-3-yl)carbamate. The molecular formula about this chemical is C₁₀H₁₆N₂O₄and the molecular weight is 228.25. It belongs to the Pharmacetical.

Physical properties about 3-Boc-amino-2,6-dioxopiperidine are: (1)ACD/LogP: 0.73; (2)ACD/LogD (pH 5.5): 0.73; (3)ACD/LogD (pH 7.4): 0.73; (4)ACD/BCF (pH 5.5): 2.1; (5)ACD/BCF (pH 7.4): 2.1; (6)ACD/KOC (pH 5.5): 59.16; (7)ACD/KOC (pH 7.4): 59.11; (8)#H bond acceptors: 6; (9)#H bond donors: 2; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 66.92Å²; (12)Index of Refraction: 1.499; (13)Molar Refractivity: 55.67 cm³; (14)Molar Volume: 189.3 cm³; (15)Polarizability: 22.07x10^-24cm³; (16)Surface Tension: 44 dyne/cm; (17)Enthalpy of Vaporization: 67.72 kJ/mol; (18)Boiling Point: 423 °C at 760 mmHg; (19)Vapour Pressure: 2.32E-07 mmHg at 25°C.

You can still convert the following datas into molecular structure:
(1)SMILES: O=C1NC(=O)CCC1NC(=O)OC(C)(C)C
(2)InChI: InChI=1/C10H16N2O4/c1-10(2,3)16-9(15)11-6-4-5-7(13)12-8(6)14/h6H,4-5H2,1-3H3,(H,11,15)(H,12,13,14)
(3)InChIKey: TUGRLMXVKASPTN-UHFFFAOYAD
(4)Std. InChI: InChI=1S/C10H16N2O4/c1-10(2,3)16-9(15)11-6-4-5-7(13)12-8(6)14/h6H,4-5H2,1-3H3,(H,11,15)(H,12,13,14)
(5)Std. InChIKey: TUGRLMXVKASPTN-UHFFFAOYSA-N

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