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Name |
3-Chloropicolinic acid |
EINECS | N/A |
CAS No. | 57266-69-0 | Density | 1.47 g/cm3 |
PSA | 50.19000 | LogP | 1.43320 |
Solubility | N/A | Melting Point |
148-150 °C |
Formula | C6H4ClNO2 | Boiling Point | 297.6 °C at 760 mmHg |
Molecular Weight | 157.556 | Flash Point | 133.8 °C |
Transport Information | N/A | Appearance | off-white solid |
Safety | 26 | Risk Codes | 22-36 |
Molecular Structure | Hazard Symbols | Xi,Xn | |
Synonyms |
3-Chloro-2-pyridinecarboxylicacid; |
Article Data | 7 |
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
With Amberlyst(R) IR-200 In methanol at 20℃; for 0.25h; | 53% |
3-chloro-2-methylpyridine
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
With potassium permanganate for 21.5h; Heating; | 45% |
3-amino-pyridine-2-carboxylic acid
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride; sodium nitrite Anschliessend Behandeln mit CuCl; |
3-chloropicolinanilide
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
With hydrogenchloride for 15h; Heating; |
2-Picolinic acid
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 0.67 h / -75 - 0 °C 1.2: 72 percent / hexachloroethane / tetrahydrofuran; hexane / 0 - 20 °C 2.1: 53 percent / Amberlyst(R) IR-200 / methanol / 0.25 h / 20 °C View Scheme |
N-phenylpicolinamide
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) n-BuLi, 2.) CCl3CCl3 / 1.) THF, -78 deg C - 0.5 h, room temperature - 1 h, 2.) THF, -78 deg C - 1 h, room temperature - 2 h 2: aq. HCl / 15 h / Heating View Scheme |
3-chloro-2-cyanopyridine
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
In methanol; sodium hydroxide; dichloromethane | |
With sodium hydroxide at 95℃; for 2h; pH=2-3; |
Conditions | Yield |
---|---|
With Graphite; sodium hydroxide In water at 25℃; for 3h; Electrolysis; | |
With Graphite; sodium hydroxide In water at 25℃; for 6h; pH=11.5 - 13.5; Reagent/catalyst; pH-value; Electrolysis; |
pyridin-3-ylamine
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1.1: hydrogenchloride; dihydrogen peroxide / water / 2 h / 5 °C 1.2: 0.42 h / -5 °C 1.3: 1.33 h / 15 - 30 °C 2.1: hydrazine hydrate / ethanol / 6 h / Reflux; Inert atmosphere 3.1: sodium hydroxide / 2 h / 95 °C / pH 2-3 View Scheme |
2,3-dichloro-pyridine
3-chloropyridine-2-carboxylic acid
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: hydrazine hydrate / ethanol / 6 h / Reflux; Inert atmosphere 2: sodium hydroxide / 2 h / 95 °C / pH 2-3 View Scheme |
The 3-Chloropicolinic acid has the cas register number 57266-69-0. And it has other names as iflab-bb f1926-0037; 3-chloropyridine-2-carboxylic acid; 3-chloropicolinic acid; 3-chloropyridine-2-carboxylicacid98%; 3-chloro-2-pyridinecarboxylic; 3-chloro-2-picolinic acid.
The physical properties of this chemical are as followings: (1)ACD/LogP: 0.30 ; (2)ACD/BCF (pH 5.5): 1; (3)ACD/BCF (pH 7.4): 1; (4)ACD/KOC (pH 5.5): 1; (5)ACD/KOC (pH 7.4): 1; (6)#H bond acceptors: 3; (7)#H bond donors: 1; (8)#Freely Rotating Bonds: 1; (9)Polar Surface Area: 39.19 ; (10)Index of Refraction: 1.59; (11)Molar Refractivity: 36.16 cm3; (12)Molar Volume: 107.1 cm3; (13)Polarizability: 14.33×10-24 cm3; (14)Surface Tension: 61 dyne/cm; (15)Density: 1.47 g/cm3; (16)Flash Point: 133.8 °C; (17)Enthalpy of Vaporization: 56.76 kJ/mol; (18)Boiling Point: 297.6 °C at 760 mmHg; (19)Vapour Pressure: 0.000599 mmHg at 25°C.
This is a kind of off-white solid, and it is usually used as a useful synthetic intermediate. Being among the irritant chemicals, it is irritant to the eyes, and it may cause inflammation to the skin or other mucous membranes. Besides, it is harmful if swallowed and it may also cause damage to health. So when you contact with this chemical, you should be very cautious and had better take the following instructions. If in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice.
This kind of chemical is usually applied in BPC(bulk pharmaceutical chemicals) and the medical intermediates. As to its raw materials, there are various, including hydrochloric acid, ethyl acetate, sulfuric acid , toluene, sodium nitrite, potassium permanganate, zinc, 6-chloro-2-methyl-3-nitropyridine, 3-amino-2-picoline; While its product categories are pharmacetical; pyridine; aromatics; pyridines.
In addition, you could obtain the molecular structure by converting the following datas:
SMILES:Clc1cccnc1C(=O)O
InChI:InChI=1/C6H4ClNO2/c7-4-2-1-3-8-5(4)6(9)10/h1-3H,(H,9,10)
InChIKey:XTMUXJBJCMRWPG-UHFFFAOYAF