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3-Fluoro-4-methylaniline
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Name

3-Fluoro-4-methylaniline

 EINECS 207-212-4
CAS No. 452-77-7 Density 1.115 g/cm3
PSA 26.02000 LogP 2.29750
Solubility N/A Melting Point 30-32 °C
Formula C7H8FN Boiling Point 203.8 °C at 760 mmHg
Molecular Weight 125.146 Flash Point 88.9 °C
Transport Information UN 2811 Appearance clear pale yellow to brownish liquid after melting
Safety 45-36/37/39-26-36/37-36 Risk Codes 36/37/38-23/24/25-20/21/22
Molecular Structure Molecular Structure of 452-77-7 (3-Fluoro-4-methylaniline) Hazard Symbols ToxicT, IrritantXi, HarmfulXn
Synonyms

p-Toluidine,3-fluoro- (6CI,7CI,8CI);(3-Fluoro-4-methylphenyl)amine;2-Fluoro-4-aminotoluene;3-Fluoro-p-toluidine;4-Amino-2-fluorotoluene;NSC 57470;

Article Data 17

3-Fluoro-4-methylaniline Synthetic route

1427-07-2

2-fluoro-4-nitrotoluene

452-77-7

3-fluoro-4-methyl-phenylamine

Conditions
ConditionsYield
With ammonium chloride; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; zinc In water at 20℃; for 7h;93%
With indium (III) iodide; 1,1,3,3-Tetramethyldisiloxane In toluene at 60℃; for 6h; Inert atmosphere; Sealed tube; chemoselective reaction;74%
With ethanol; platinum Hydrogenation;
88-72-2

1-methyl-2-nitrobenzene

452-77-7

3-fluoro-4-methyl-phenylamine

Conditions
ConditionsYield
aluminum nickel In ethanol
452-75-5

4-chloro-2-fluorotoluene

452-77-7

3-fluoro-4-methyl-phenylamine

Conditions
ConditionsYield
Stage #1: 4-chloro-2-fluorotoluene With [(k2-P,N-di(1-adamantyl)-2-morpholinophenylphosphine)Pd(Ph)Cl]; sodium t-butanolate In 1,4-dioxane Inert atmosphere; Glovebox;
Stage #2: With ammonia In 1,4-dioxane at 24℃; Inert atmosphere; Glovebox;		62%
With bis[chloro(1,2,3-trihapto-allylbenzene)palladium(II)]; N-[2-(di(1-adamantyl)phosphino)phenyl]morpholine; ammonia; sodium t-butanolate In 1,4-dioxane at 65℃; for 20h; Inert atmosphere; chemoselective reaction;61%
372-19-0

meta-fluoroaniline

593-53-3

Methyl fluoride

A

443-86-7

3-fluoro-2-methylaniline

B

367-29-3

3-fluoro-6-methylaniline

C

452-77-7

3-fluoro-4-methyl-phenylamine

Conditions
ConditionsYield
With oxygen; trimethylamine In gaseous matrix at 80℃; Irradiation;A 56 % Spectr.
B 25 % Spectr.
C 19 % Spectr.
106-49-0

p-toluidine

A

3,5-difluoro-4-methylaniline

B

2,5-difluoro-4-methylaniline

C

452-80-2

2-fluoro-4-methylaniline

D

452-77-7

3-fluoro-4-methyl-phenylamine

Conditions
ConditionsYield
With trifluorormethanesulfonic acid; fluorine at 20℃; Title compound not separated from byproducts;
3-fluoro-4-methyl-phenylamine

3-fluoro-4-methyl-phenylamine

108-24-7

acetic anhydride

458-10-6

N-(3-fluoro-4-methylphenyl)acetamide

452-77-7

3-fluoro-4-methyl-phenylamine

202865-78-9

2-bromo-5-fluoro 4-methylaniline

Conditions
ConditionsYield
With bromine; potassium carbonate In dichloromethane at -15℃; for 1h;100%
With bromine; potassium carbonate In dichloromethane at -15℃; for 1h;100%
With bromine; potassium carbonate In dichloromethane at -15℃; for 1h;100%
452-77-7

3-fluoro-4-methyl-phenylamine

333-20-0

potassium thioacyanate

1155287-47-0

5-fluoro-6-methylbenzo[d]thiazol-2-amine

Conditions
ConditionsYield
With acetic acid at 20℃; for 3h;99%
Stage #1: 3-fluoro-4-methyl-phenylamine; potassium thioacyanate With bromine; acetic acid at 20℃; for 20.33h;
Stage #2: With ammonia In water for 2h; pH=8;		98%
452-77-7

3-fluoro-4-methyl-phenylamine

999-97-3

1,1,1,3,3,3-hexamethyl-disilazane

C10H16FNSi

Conditions
ConditionsYield
With sulfuric acid at 170 - 175℃; for 1h;98%
452-77-7

3-fluoro-4-methyl-phenylamine

C11H8FN

(R)-3-fluoro-N-(2-fluoro-2-(quinolin-2-yl)ethyl)-4-methylaniline

Conditions
ConditionsYield
Stage #1: C11H8FN With (S)-3,3'-bis(2,4,6-tri-iso-propylphenyl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate at -20℃; for 0.25h; Michael Addition; Sealed tube; Inert atmosphere;
Stage #2: 3-fluoro-4-methyl-phenylamine at -20℃; for 120h; Sealed tube; Inert atmosphere; enantioselective reaction;		98%

3-Fluoro-4-methylaniline Chemical Properties

IUPAC Name:3-fluoro-4-methylaniline
Molecular Formula:C7H8FN
Molecular Weight:125.143523 g/mol
Melting Point:30-32 °C
Boiling Point:93°C 12mm
Flash Point:88 °C
density:1.093 
refractive index:1.5385-1.5405   
BRN:2715987
CAS DataBase Reference:452-77-7(CAS DataBase Reference)
Synonyms of 2-Fluoro-4-aminotoluene(452-77-7):
2-FLUORO-4-AMINO-TOLUENE;3-FLUORO-4-METHYLANILINE;3-FLUORO-4-METHYLBENZENEAMINE;3-FLUORO-P-TOLUIDINE;4-AMINO-2-FLUOROTOLUENE;3-fluoro-4-methyl-benzenamin;3-fluoro-p-toluidin;3-Fluoro-4-methylaniline 98%
Categories of 2-Fluoro-4-aminotoluene(452-77-7):
Fluorobenzene;Anilines, Aromatic Amines and Nitro Compounds;Aniline;Miscellaneous;Anilines, Amides & Amines;Fluorine Compounds

3-Fluoro-4-methylaniline Safety Profile

Safety Information of 2-Fluoro-4-aminotoluene(452-77-7):
Hazard Codes:T ,Xi,Xn
Risk Statements:36/37/38-23/24/25-20/21/22
36/37/38:Irritating to eyes, respiratory system and skin 
23/24/25:Toxic by inhalation, in contact with skin and if swallowed 
20/21/22:Harmful by inhalation, in contact with skin and if swallowed
Safety Statements:45-36/37/39-26-36/37-36
45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible)
36/37/39:Wear suitable protective clothing, gloves and eye/face protection 
26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36/37:Wear suitable protective clothing and gloves
36:Wear suitable protective clothing     
RIDADR:2811
RTECS:XU6825000
Hazard Note:Toxic/Irritant
HazardClass:6.1(b)
PackingGroup:I

3-Fluoro-4-methylaniline Specification

First Aid Measures of 2-Fluoro-4-aminotoluene(452-77-7):
Skin:Get medical aid. Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Wash clothing before reuse.
Eyes:Immediately flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid.
Ingestion:Never give anything by mouth to an unconscious person. Get medical aid. Do NOT induce vomiting. If conscious and alert, rinse mouth and drink 2-4 cupfuls of milk or water.
Inhalation:Remove from exposure to fresh air immediately. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Get medical aid. DO NOT use mouth-to-mouth respiration.
Storage of 2-Fluoro-4-aminotoluene(452-77-7):
Keep away from heat, sparks, and flame. Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances.

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