Welcome to LookChem.com Sign In|Join Free
  • or
Home > Products >  > 

3-Methyl-4-aminobenzensulfonamide
Related Products

Hot Products

Basic Information Post buying leads Suppliers Cas Database
Name

3-Methyl-4-aminobenzensulfonamide

 EINECS N/A
CAS No. 53297-70-4 Density 1.359 g/cm3
PSA 94.56000 LogP 2.58690
Solubility N/A Melting Point 174 °C
Formula C7H10N2O2S Boiling Point 409.3 °C at 760 mmHg
Molecular Weight 186.235 Flash Point 201.3 °C
Transport Information N/A Appearance N/A
Safety 22-26-36/37/39 Risk Codes 20/21/22-36/37/38
Molecular Structure Molecular Structure of 53297-70-4 (3-Methyl-4-aminobenzensulfonamide) Hazard Symbols IrritantXi
Synonyms

2-Methyl-4-sulfamoylaniline;4-Amino-3-methylbenzenesulfonamide;

Article Data 7

3-Methyl-4-aminobenzensulfonamide Synthetic route

252562-03-1

N-[4-(aminosulfonyl)-2-methylphenyl]acetamide

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
With hydrogenchloride In ethanol; water at 80℃;100%
With hydrogenchloride; water In ethanol Reflux;100%
Stage #1: N-[4-(aminosulfonyl)-2-methylphenyl]acetamide With hydrogenchloride In ethanol; water Heating / reflux;
Stage #2: With sodium hydrogencarbonate In ethanol; water at 20℃;		93%
With hydrogenchloride
With hydrogenchloride In ethanol for 1h; Heating;
14988-21-7

4-(acetylamino)-3-methylbenzenesulfonyl chloride

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: NH4OH / tetrahydrofuran / 0.33 h / 20 °C
2: aq. HCl / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 2 steps
1: ammonium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C
2: hydrogenchloride; water / ethanol / Reflux
View Scheme

sodium 4-(acetylamino)-3-methylbenzenesulfonate

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: thionyl chloride / dimethylformamide / 2 h / -4 °C
2: NH4OH / tetrahydrofuran / 0.33 h / 20 °C
3: aq. HCl / ethanol / 1 h / Heating
View Scheme
Multi-step reaction with 3 steps
1: thionyl chloride / N,N-dimethyl-formamide / 2 h / -40 - 20 °C
2: ammonium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C
3: hydrogenchloride; water / ethanol / Reflux
View Scheme

C10H15N3O2S

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
Stage #1: C10H15N3O2S With lithium hydroxide; water In methanol at 50℃; for 5h;
Stage #2: With hydrogenchloride In methanol; water at 25℃; for 0.25h; pH=9;
98-33-9

2-aminotoluene-5-sulfonic acid

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 4 steps
1.1: pyridine / 2 h / 20 °C
2.1: sodium hydroxide / pyridine / 3 h / 20 °C
2.2: 2 h / -30 - 40 °C
3.1: ammonium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C
4.1: hydrogenchloride / ethanol; water / 80 °C
View Scheme
Multi-step reaction with 5 steps
1: pyridine / 2 h / 20 °C
2: sodium hydroxide / water / 3 h / 20 °C
3: thionyl chloride / N,N-dimethyl-formamide / 2 h / -40 - 20 °C
4: ammonium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C
5: hydrogenchloride; water / ethanol / Reflux
View Scheme

4-acetamido-3-methylbenzenesulfonic acid

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1.1: sodium hydroxide / pyridine / 3 h / 20 °C
1.2: 2 h / -30 - 40 °C
2.1: ammonium hydroxide / tetrahydrofuran / 1 h / 0 - 20 °C
3.1: hydrogenchloride / ethanol; water / 80 °C
View Scheme
Multi-step reaction with 4 steps
1: sodium hydroxide / water / 3 h / 20 °C
2: thionyl chloride / N,N-dimethyl-formamide / 2 h / -40 - 20 °C
3: ammonium hydroxide / water; tetrahydrofuran / 1 h / 0 - 20 °C
4: hydrogenchloride; water / ethanol / Reflux
View Scheme

6-nitro-toluene-3-sulfonic acid amide

53297-70-4

4-amino-3-methylbenzenesulfonamide

Conditions
ConditionsYield
With palladium on activated charcoal; hydrogen In methanol at 20℃;
1007571-96-1

[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetyl chloride

53297-70-4

4-amino-3-methylbenzenesulfonamide

2-[4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide

Conditions
ConditionsYield
Stage #1: [4-chloro-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-acetyl chloride; 4-amino-3-methylbenzenesulfonamide With sodium hydrogencarbonate In acetone at 20℃; for 24h;
Stage #2: With hydrogenchloride In water; acetone at 0℃;		90%
1056598-54-9

C15H7BrCl2FNO2

53297-70-4

4-amino-3-methylbenzenesulfonamide

2-[4-Bromo-3-(3-chloro-5-cyano-phenoxy)-2-fluoro-phenyl]-N-(2-methyl-4-sulfamoyl-phenyl)-acetamide

Conditions
ConditionsYield
Stage #1: C15H7BrCl2FNO2; 4-amino-3-methylbenzenesulfonamide With sodium hydrogencarbonate In acetone at 0 - 20℃; for 24h;
Stage #2: With hydrogenchloride In water; acetone		87%
Stage #1: C15H7BrCl2FNO2; 4-amino-3-methylbenzenesulfonamide With sodium hydrogencarbonate In acetone at 20℃; for 24h;
Stage #2: With hydrogenchloride In water; acetone at 0℃;		87%
53297-70-4

4-amino-3-methylbenzenesulfonamide

598-21-0

2-Bromoacetyl bromide

329944-57-2

N-[4-(aminosulfonyl)-2-methylphenyl]-2-bromoacetamide

Conditions
ConditionsYield
With pyridine In chloroform at 20℃;69%
With pyridine In chloroform at 0 - 20℃; for 18.3333h;69%

3-Methyl-4-aminobenzensulfonamide Specification

The 3-Methyl-4-aminobenzensulfonamide is an organic compound with the formula C7H10N2O2S. The IUPAC name of this chemical is 4-amino-3-methylbenzenesulfonamide. With the CAS registry number 53297-70-4, it is also named as benzenesulfonamide, 4-amino-3-methyl-. The product's categories are Sulfonamide; Phenyls & Phenyl-Het; Miscellaneous.

The other characteristics of 3-Methyl-4-aminobenzensulfonamide can be summarized as: (1)ACD/LogP: -0.26; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -0.26; (4)ACD/LogD (pH 7.4): -0.26; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 17.2; (8)ACD/KOC (pH 7.4): 17.19; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 2; (12)Index of Refraction: 1.609; (13)Molar Refractivity: 47.43 cm3; (14)Molar Volume: 136.9 cm3; (15)Polarizability: 18.8×10-24 cm3; (16)Surface Tension: 58.8 dyne/cm; (17)Enthalpy of Vaporization: 66.15 kJ/mol; (18)Vapour Pressure: 6.56E-07 mmHg at 25°C; (19)Rotatable Bond Count: 1; (20)Exact Mass: 186.046298; (21)MonoIsotopic Mass: 186.046298; (22)Topological Polar Surface Area: 94.6; (23)Heavy Atom Count: 12; (24)Complexity: 245.

People can use the following data to convert to the molecule structure.
1. SMILES:O=S(=O)(c1ccc(N)c(c1)C)N
2. InChI:InChI=1/C7H10N2O2S/c1-5-4-6(12(9,10)11)2-3-7(5)8/h2-4H,8H2,1H3,(H2,9,10,11) 
3. InChIKey:IGQGXIVCGKMRAM-UHFFFAOYAW
4. Std. InChI:InChI=1S/C7H10N2O2S/c1-5-4-6(12(9,10)11)2-3-7(5)8/h2-4H,8H2,1H3,(H2,9,10,11)
5. Std. InChIKey:IGQGXIVCGKMRAM-UHFFFAOYSA-N

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 53297-70-4