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4-(2-Aminoethyl)benzenesulfonamide
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Name

4-(2-Aminoethyl)benzenesulfonamide

 EINECS 252-501-0
CAS No. 35303-76-5 Density 1.293 g/cm3
PSA 94.56000 LogP 2.31660
Solubility 15.5g/L at 20℃ Melting Point 150-152 °C(lit.)
Formula C8H12N2O2S Boiling Point 387.4 °C at 760 mmHg
Molecular Weight 200.261 Flash Point 188.1 °C
Transport Information N/A Appearance white to yellowish crystalline powder powder
Safety 26-36/37/39-45 Risk Codes 22-34
Molecular Structure Molecular Structure of 35303-76-5 (4-(2-Aminoethyl)benzenesulfonamide) Hazard Symbols CorrosiveC
Synonyms

Benzenesulfonamide,p-(2-aminoethyl)- (5CI);2-(4-Sulfamoylphenyl)ethylamine;2-[4-(Aminosulfonyl)phenyl]ethylamine;4-(Aminosulfonyl)phenethylamine;4-Sulfamoylphenethylamine;p-(2-Aminoethyl)benzenesulfonamide;p-Aminoethyl-benzenesulfonamide;

Article Data 7

4-(2-Aminoethyl)benzenesulfonamide Synthetic route

3665-08-5

4-cyanomethyl-benzenesulfonic acid amide

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
With sodium methylate; nickel In methanol at 45℃; Electrochemical reaction;86%
41472-49-5

4-(β-acetylaminoethyl)phenylsulfonamide

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
With sodium hydroxide; water for 3h; Reflux;78%
With hydrogenchloride
90610-69-8

4-(2-carboxyethyl)-benzenesulfonamide

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
With pyridine; thionyl chloride; chloroform Behandeln des Reaktionsprodukts mit Natriumazid in wss. Aceton und Erwaermen des erhaltenen Azids in Benzol;
147723-92-0

4-sulfamoyl-trans-cinnamic acid

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous NaOH-solution; sodium-amalgam
2: thionyl chloride; chloroform; pyridine / Behandeln des Reaktionsprodukts mit Natriumazid in wss. Aceton und Erwaermen des erhaltenen Azids in Benzol
View Scheme
877-95-2

methyl-N-(benzyl-methyl)-formamide

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: chlorosulfuric acid
2: aqueous ammonia
3: aqueous hydrochloric acid
View Scheme
35450-53-4

sulfonyl chloride

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: aqueous ammonia
2: aqueous hydrochloric acid
View Scheme
67514-65-2

4-ethylpyrazole-1-carboxylic acid chloride

4747-71-1

cyclopentyl isocyanate

A

4-[2-(4-ethylpyrazole-1-carbonamide)-ethyl]-benzenesulphonamide

4-[2-(4-ethylpyrazole-1-carbonamide)-ethyl]-benzenesulphonamide

B

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

67514-73-2

3,5-dimethyl-4-chloropyrazole-1-carboxylic acid chloride

A

4-[2-(3,5-dimethyl-4-chloropyrazole-1-carbonamide)-ethyl]-benzenesulphonamide

4-[2-(3,5-dimethyl-4-chloropyrazole-1-carbonamide)-ethyl]-benzenesulphonamide

B

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

64-04-0

phenethylamine

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: pyridine / tetrahydrofuran / 4 h / 20 °C / Cooling with ice
2: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice
3: ammonium hydroxide / acetone / 20 °C
View Scheme
458-85-5

2,2,2-trifluoro-N-(2-phenylethyl)acetamide

35303-76-5

4-(2-aminoethyl)benzenesulfonamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: chlorosulfonic acid / 2 h / 20 °C / Cooling with ice
2: ammonium hydroxide / acetone / 20 °C
View Scheme

4-(2-Aminoethyl)benzenesulfonamide Specification

The 4-(2-Aminoethyl)benzenesulfonamide, with the CAS registry number 35303-76-5 and EINECS registry number 252-501-0, and belongs to the following product categories: Sulfonamide; Benzene derivates; (Intermediate of glibenclamide,glipizide,gliquido; Organic Building Blocks; Sulfonamides/Sulfinamides; Sulfur Compounds. It is a kind of white to yellowish crystalline powder, and its molecular formula is C8H12N2O2S.

The physical properties of 4-(2-Aminoethyl)benzenesulfonamide are as followings: (1)ACD/LogP: -0.43; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): -3.48; (4)ACD/LogD (pH 7.4): -2.46; (5)ACD/BCF (pH 5.5): 1; (6)ACD/BCF (pH 7.4): 1; (7)ACD/KOC (pH 5.5): 1; (8)ACD/KOC (pH 7.4): 1; (9)#H bond acceptors: 4; (10)#H bond donors: 4; (11)#Freely Rotating Bonds: 4; (12)Polar Surface Area: 49 Å2; (13)Index of Refraction: 1.587; (14)Molar Refractivity: 52.07 cm3; (15)Molar Volume: 154.8 cm3; (16)Polarizability: 20.64×10-24cm3; (17)Surface Tension: 54.6 dyne/cm; (18)Density: 1.293 g/cm3; (19)Flash Point: 188.1 °C; (20)Enthalpy of Vaporization: 63.64 kJ/mol; (21)Boiling Point: 387.4 °C at 760 mmHg; (22)Vapour Pressure: 3.31E-06 mmHg at 25°C.

Uses of 4-(2-Aminoethyl)benzenesulfonamide: It can react with naphthalen-1-yl-acetyl chloride to produce p-[2-(a-naphthylacetamido)ethyl]benzenesulphonamide. This reaction will need reagent benzene. The reaction time is 4 hours with heating, and the yield is about 68%.

You should be cautious while dealing with this chemical. It is harmful if swallowed, and may cause burns. Therefore, you had better take the following instructions: Wear suitable protective clothing, gloves and eye/face protection, and in case of contacting with eyes, rinse immediately with plenty of water and seek medical advice; In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: O=S(=O)(c1ccc(cc1)CCN)N
(2)InChI: InChI=1/C8H12N2O2S/c9-6-5-7-1-3-8(4-2-7)13(10,11)12/h1-4H,5-6,9H2,(H2,10,11,12)
(3)InChIKey: FXNSVEQMUYPYJS-UHFFFAOYAP

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