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Cas Database |
| Name |
4-(4-Aminophenoxy)-N-methylpicolinamide |
EINECS | 608-211-5 |
| CAS No. | 284462-37-9 | Density | 1.241 g/cm3 |
| PSA | 77.24000 | LogP | 2.78780 |
| Solubility | N/A | Melting Point |
110-112 °C |
| Formula | C13H13N3O2 | Boiling Point | 476.8 °C at 760 mmHg |
| Molecular Weight | 243.265 | Flash Point | 242.2 °C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
2-Pyridinecarboxamide,4-(4-aminophenoxy)-N-methyl-;4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin;[4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide; |
Article Data | 70 |
4-(4-Aminophenoxy)-N-methylpicolinamide Synthetic route
- 123-30-8
4-amino-phenol
- 220000-87-3
4-chloro-N-methylpicolinamide
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
| With potassium tert-butylate In N,N-dimethyl-formamide at 25℃; for 1h; | 97% |
| Stage #1: 4-amino-phenol With potassium hydroxide for 0.166667h; Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; | 97.3% |
| With 18-crown-6 ether In acetonitrile for 1.5h; Reagent/catalyst; Solvent; Temperature; Reflux; | 92.5% |
- 864272-34-4
4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
| With hydrogen; nickel In tetrahydrofuran; methanol at 20℃; Product distribution / selectivity; | 97% |
| With palladium 10% on activated carbon; hydrogen In methanol at 35℃; under 2068.65 Torr; for 2h; | 95% |
| With palladium 10% on activated carbon; hydrogen In methanol at 40 - 50℃; under 7500.75 Torr; Solvent; Autoclave; | 92.5% |
| Stage #1: 4-(4-nitro)benzyloxy-2-carbonylmethylaminopyridine With iron(III) chloride hexahydrate; pyrographite In ethanol at 90℃; for 0.5h; Sonication; Stage #2: With hydrazine hydrate In ethanol Sonication; | 70% |
| With ammonia; tetra(n-butyl)ammonium hydrogensulfate; iron | 20.1 g |
- 100-02-7
4-nitro-phenol
- 220000-87-3
4-chloro-N-methylpicolinamide
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
| Stage #1: 4-nitro-phenol; 4-chloro-N-methylpicolinamide With potassium carbonate for 4h; Reflux; Stage #2: With iron(III) chloride; hydrazine hydrate; FeCl3/C In ethanol for 3h; Concentration; Reflux; | 94.6% |
| Stage #1: 4-nitro-phenol With potassium hydroxide for 0.166667h; Heating; Green chemistry; Stage #2: 4-chloro-N-methylpicolinamide for 1.5h; Green chemistry; Stage #3: With iron(III) chloride; pyrographite; hydrazine hydrate In ethanol; 1,2-dichloro-ethane for 3h; Reflux; Green chemistry; | 94.5% |
| Conditions | Yield |
|---|---|
| With potassium carbonate In water; N,N-dimethyl-formamide at -5 - 10℃; for 1.5h; Large scale; | 84.1% |
- 73771-11-6
4-chloropyridine-2-carbohydrazide
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
| Stage #1: With potassium tert-butylate In tetrahydrofuran; N,N-dimethyl-formamide at 20℃; for 2h; Inert atmosphere; Stage #2: 4-chloropyridine-2-carbohydrazide With potassium carbonate In tetrahydrofuran; N,N-dimethyl-formamide at 80℃; for 6h; Inert atmosphere; | 80% |
- 220000-87-3
4-chloro-N-methylpicolinamide
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
| Stage #1: 4-amino-phenol With sodium hydride In N,N-dimethyl-formamide at 20℃; for 2h; Stage #2: 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 8h; | 71% |
| With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide at 20 - 80℃; for 10h; Product distribution / selectivity; | |
| Multi-step reaction with 2 steps 1: ethyl acetate 2: ammonia; iron; tetra(n-butyl)ammonium hydrogensulfate View Scheme |
- 114780-06-2
4-chloro-N,N-dimethylpyridine-2-carboxamide
- 123-30-8
4-amino-phenol
- 220000-87-3
4-chloro-N-methylpicolinamide
A
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
B
- 284462-86-8
4-(4-aminophenoxy)-N,N-dimethylpicolinamide
| Conditions | Yield |
|---|---|
| Stage #1: 4-amino-phenol With potassium tert-butylate In N,N-dimethyl-formamide at 20℃; for 1h; Stage #2: 4-chloro-N,N-dimethylpyridine-2-carboxamide; 4-chloro-N-methylpicolinamide With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 4h; Inert atmosphere; | A 70% B 69% |
- 284462-78-8
4-(3-aminophenoxy)-N-methylpicolinamide
- 32315-10-9
bis(trichloromethyl) carbonate
- 67291-63-8
2-amino-3-methoxynaphthalene
A
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
- 284462-56-2
3-(4-aminophenoxy)-N-methylbenzamide
- 320-51-4
4-chloro-3-trifluoromethyl-aniline
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
- 220000-87-3
4-chloro-N-methylpicolinamide
A
- 284462-37-9
4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
| Conditions | Yield |
|---|---|
| With potassium tert-butylate; potassium carbonate In N,N-dimethyl-formamide |
4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties
Molecular structure of 4-(4-Aminophenoxy)-N-methylpicolinamide (CAS NO.284462-37-9) is:
Product Name: 4-(4-Aminophenoxy)-N-methylpicolinamide
CAS Registry Number: 284462-37-9
Systematic Name: 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide
Empirical Formula: C13H13N3O2
Molecular Weight: 243.2612
Melting Point: 110-112°C
Index of Refraction: 1.618
Molar Refractivity: 68.64 cm3
Molar Volume: 195.8 cm3
Surface Tension: 54.2 dyne/cm
Density: 1.241 g/cm3
Flash Point: 242.2 °C
Enthalpy of Vaporization: 74.06 kJ/mol
Boiling Point: 476.8 °C at 760 mmHg
Vapour Pressure: 2.96E-09 mmHg at 25°C
Product Categories: Sorafinib;Aromatics Compounds;Aromatics;Bases & Related Reagents;Heterocycles;Nucleotides
4-(4-Aminophenoxy)-N-methylpicolinamide Specification
4-(4-Aminophenoxy)-N-methylpicolinamide , its cas register number is 284462-37-9. It also can be called 2-Pyridinecarboxamide,4-(4-aminophenoxy)-N-methyl- ; 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide ; 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin ; [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide .It is a light-brown solid.
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