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4-(Ethylaminomethyl)pyridine

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Name

4-(Ethylaminomethyl)pyridine

EINECS 251-506-5
CAS No. 33403-97-3 Density 0.967 g/cm3
PSA 24.92000 LogP 1.58200
Solubility miscible with water Melting Point N/A
Formula C8H12N2 Boiling Point 219.1 °C at 760 mmHg
Molecular Weight 136.197 Flash Point 98.3 °C
Transport Information N/A Appearance Colorless to Yellow Liquid
Safety 26-37/39 Risk Codes 36/37/38
Molecular Structure Molecular Structure of 33403-97-3 (4-(Ethylaminomethyl)pyridine) Hazard Symbols IrritantXi
Synonyms

Pyridine,4-[(ethylamino)methyl]- (7CI,8CI);4-(N-Ethylaminomethyl)pyridine;4-[(Ethylamino)methyl]pyridine;Ethyl(4-pyridinylmethyl)amine;N-(4-Pyridylmethyl)ethylamine;N-Ethyl-4-picolylamine;N-Ethyl-4-pyridinemethanamine;N-Ethyl-N-(pyridin-4-ylmethyl)amine;N-[(Pyridin-4-yl)methyl]ethylamine;NSC 85903;g-Picolylethylamine;

Article Data 9

4-(Ethylaminomethyl)pyridine Synthetic route

54433-74-8

Ethyl-[1-pyridin-4-yl-meth-(E)-ylidene]-amine

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

Conditions
ConditionsYield
With sodium tetrahydroborate; water at 10 - 25℃;56.2%
With sodium tetrahydroborate In ethanol at 20℃; for 12h;2.3 g
With sodium tetrahydroborate In ethanol; water for 20h;
1508-75-4

tropicamide

A

492-38-6

2-phenylacrylic acid

B

529-64-6

Tropic acid

C

57322-50-6

N-ethyl-N-(4-picolyl)-atropamide

D

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

Conditions
ConditionsYield
With sodium hydroxide In water for 10h; Heating;
872-85-5

pyridine-4-carbaldehyde

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: ethanol / 10 h / 20 °C
2: sodium tetrahydroborate / ethanol / 12 h / 20 °C
View Scheme
Multi-step reaction with 2 steps
1: ethanol / water / 0.5 h / Cooling
2: sodium tetrahydroborate; ethanol / water / 20 h
View Scheme
Multi-step reaction with 2 steps
1: ethanol; water / 0 - 10 °C
2: sodium tetrahydroborate / ethanol; water / 10 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: ethanol; water / 0 - 20 °C
2: sodium tetrahydroborate / 10 - 25 °C
View Scheme
Multi-step reaction with 2 steps
1: ethanol; water / 0 - 20 °C
2: sodium tetrahydroborate; water / 10 - 25 °C
View Scheme
75-15-0

carbon disulfide

1135-99-5

diphenyltin(IV) dichloride

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

1398712-61-2

4-(ethylaminodithiocarbamate)methylpyridine diphenyltin(IV)

Conditions
ConditionsYield
Stage #1: carbon disulfide; 4-(ETHYLAMINOMETHYL)PYRIDINE With potassium hydroxide In methanol at 20℃; for 2h;
Stage #2: diphenyltin(IV) dichloride In methanol for 2h;
99%
33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

407-25-0

trifluoroacetic anhydride

N-ethyl-2,2,2-trifluoro-N-(pyridin-4-ylmethyl)acetamide

Conditions
ConditionsYield
With triethylamine In dichloromethane at 0 - 20℃; for 15h; Inert atmosphere;98%
33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

65-85-0

benzoic acid

329715-70-0

N-ethyl-N-(pyridin-4-ylmethyl)benzamide

Conditions
ConditionsYield
Stage #1: 4-(ETHYLAMINOMETHYL)PYRIDINE; benzoic acid With triethylamine In tetrahydrofuran at 20℃; for 0.0833333h; Inert atmosphere;
Stage #2: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In tetrahydrofuran at 0 - 20℃; Inert atmosphere;
97%
33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

76-05-1

trifluoroacetic acid

C8H12N2*C2HF3O2

Conditions
ConditionsYield
In ethanol at 20℃; Solvent; Temperature;95.8%
75-75-2

methanesulfonic acid

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

C8H12N2*CH4O3S

Conditions
ConditionsYield
In ethyl acetate at 20℃; Solvent; Temperature;93.3%
201230-82-2

carbon monoxide

20‑iodo‑5α‑pregn‑20‑ene

33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

C30H44N2O

Conditions
ConditionsYield
With palladium diacetate; triethylamine; triphenylphosphine In N,N-dimethyl-formamide at 50℃; under 750.075 Torr; for 24h; chemoselective reaction;93%
33403-97-3

4-(ETHYLAMINOMETHYL)PYRIDINE

140-88-5

ethyl acrylate

1001397-05-2

ethyl 3-{N-ethyl-N-[(pyridine-4-yl)methyl]amino}propanoate

Conditions
ConditionsYield
With samarium(III) trifluoromethanesulfonate In dichloromethane at 20℃; for 2h; aza-Michael reaction;92%

4-(Ethylaminomethyl)pyridine Specification

The 4-(Ethylaminomethyl)pyridine is an organic compound with the formula C8H12N2. The IUPAC name of this chemical is N-(pyridin-4-ylmethyl)ethanamine. With the CAS registry number 33403-97-3, it is also named as N-Ethyl-4-pyridinemethylamine. The product's categories are Heterocyclic Compounds; C7 and C8; Heterocyclic Building Blocks; Pyridines. Besides, it is a colorless to yellow  liquid, which should be stored in a closed, cool, dry place.

Physical properties about 4-(Ethylaminomethyl)pyridine are: (1)ACD/LogP: 0.56; (2)ACD/LogD (pH 5.5): -2.24; (3)ACD/LogD (pH 7.4): -0.58; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 1; (7)ACD/KOC (pH 7.4): 3.52; (8)#H bond acceptors: 2; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 3; (11)Polar Surface Area: 16.13 Å2; (12)Index of Refraction: 1.51; (13)Molar Refractivity: 42.12 cm3; (14)Molar Volume: 140.7 cm3; (15)Polarizability: 16.69×10-24cm3; (16)Surface Tension: 36.3 dyne/cm; (17)Density: 0.967 g/cm3; (18)Flash Point: 98.3 °C; (19)Enthalpy of Vaporization: 45.55 kJ/mol; (20)Boiling Point: 219.1 °C at 760 mmHg; (21)Vapour Pressure: 0.121 mmHg at 25°C.

When you are using this chemical, please be cautious about it as the following:
This chemical is irritating to eyes, respiratory system and skin. When you are using it, wear suitable protective clothing and eye/face protection. In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

You can still convert the following datas into molecular structure:
(1)SMILES: n1ccc(cc1)CNCC
(2)InChI: InChI=1/C8H12N2/c1-2-9-7-8-3-5-10-6-4-8/h3-6,9H,2,7H2,1H3
(3)InChIKey: ZBAMQLFFVBPAOX-UHFFFAOYAW
(4)Std. InChI: InChI=1S/C8H12N2/c1-2-9-7-8-3-5-10-6-4-8/h3-6,9H,2,7H2,1H3
(5)Std. InChIKey: ZBAMQLFFVBPAOX-UHFFFAOYSA-N

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