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4,5-Dichloro-2-nitroaniline

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Name

4,5-Dichloro-2-nitroaniline

EINECS 229-657-3
CAS No. 6641-64-1 Density 1.624 g/cm3
PSA 71.84000 LogP 3.58820
Solubility 60.3mg/L at 25℃ Melting Point 180-181 ºC
Formula C6H4Cl2N2O2 Boiling Point 347.1 °C at 760 mmHg
Molecular Weight 207.016 Flash Point 163.7 °C
Transport Information N/A Appearance light yellow solid powder
Safety S22;S26;S36/37/39 Risk Codes R20/21/22;R36/37/38   
Molecular Structure Molecular Structure of 6641-64-1 (4,5-Dichloro-2-nitroaniline) Hazard Symbols
Synonyms

Benzenamine, 4,5-dichloro-2-nitro-;3,4-DICHLORO-6-NITROANILINE;4,5-DICHLORO-2-NITROANILINE;4,5-DICHLORO-2-NITROBENZENAMINE;TIMTEC-BB SBB003477;4,5-Dichloro-2-nitroaniline 98%;2-NITRO-4,5-DICHLOROANILINE

Article Data 13

4,5-Dichloro-2-nitroaniline Synthetic route

99-54-7

3,4-dichloronitrobenzene

A

65078-77-5

2,3-dichloro-6-nitroaniline

B

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
With O-Methylhydroxylamin; potassium tert-butylate; copper diacetate In monoethylene glycol diethyl ether at 20℃; for 2h; Substitution; Amination;A 75%
B 14%
89-69-0

2,4,5-Trichloronitrobenzene

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
With ammonia In water; isopropyl alcohol at 120℃; for 6h;48.3%
With ethanol; ammonia at 200℃;
6306-39-4

1,2-dichloro-4,5-dinitrobenzene

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
With ethanol; ammonia
5462-30-6

N-(4,5-dichloro-2-nitrophenyl)acetamide

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
With sulfuric acid at 120℃;
With sulfuric acid at 100℃; for 0.25h;
2150-93-8

N-(3,4-dichlorophenyl)acetamide

A

6641-64-1

4,5-dichloro-2-nitroaniline

B

3.4-dichloro-2(?)-nitro-acetanilide and 3.4-dichloro-2(?).6-dinitro-acetanilide

3.4-dichloro-2(?)-nitro-acetanilide and 3.4-dichloro-2(?).6-dinitro-acetanilide

Conditions
ConditionsYield
With nitric acid man trennt durch fraktionierte Krystallisation aus Alkohol; zur Abspaltung der Acetylgruppe erwaermt man mit konz.Schwefelsaeure;
89-69-0

2,4,5-Trichloronitrobenzene

7664-41-7

ammonia

6641-64-1

4,5-dichloro-2-nitroaniline

6306-39-4

1,2-dichloro-4,5-dinitrobenzene

7664-41-7

ammonia

6641-64-1

4,5-dichloro-2-nitroaniline

2150-93-8

N-(3,4-dichlorophenyl)acetamide

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
2: conc. sulfuric acid / 0.25 h / 100 °C
View Scheme
95-76-1

m,p-dichloroaniline

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: acetic acid / 0.25 h / Heating
2: 60percent nitric acid, conc. sulfuric acid / 1.) 0 deg C, 10 min, 2.) RT, 30 min
3: conc. sulfuric acid / 0.25 h / 100 °C
View Scheme
95-50-1

1,2-dichloro-benzene

6641-64-1

4,5-dichloro-2-nitroaniline

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: beim Nitrieren
2: alcohol; ammonia
View Scheme

4,5-Dichloro-2-nitroaniline Chemical Properties

IUPAC Name: 4,5-dichloro-2-nitroaniline
The MF of 4,5-Dichloro-2-nitroaniline(6641-64-1): C6H4Cl2N2O2
The MW of 4,5-Dichloro-2-nitroaniline(6641-64-1): 207.01
EINECS: 229-657-3
Density: 1.624 g/cm3 
Flash Point: 163.7 °C 
Boiling Point: 347.1 °C at 760 mmHg 
Index of Refraction: 1.655 
mp: 177-179 °C(lit.)
Categories: Amines;blocks;NitroCompounds;Amines and Anilines;Anilines, Aromatic Amines and Nitro Compounds;API intermediates;Anilines, Amides & Amines;Chlorine Compounds;Nitro Compounds;C2 to C6;Nitrogen Compounds
Synonyms: Benzenamine, 4,5-dichloro-2-nitro-;3,4-DICHLORO-6-NITROANILINE;4,5-DICHLORO-2-NITROANILINE;4,5-DICHLORO-2-NITROBENZENAMINE;TIMTEC-BB SBB003477;4,5-Dichloro-2-nitroaniline 98%;2-NITRO-4,5-DICHLOROANILINE;2-Nitro-4,5-dichlorobenzenamine
The Structure of 4,5-Dichloro-2-nitroaniline(6641-64-1):

4,5-Dichloro-2-nitroaniline Uses

4,5-Dichloro-2-nitroaniline(6641-64-1) is  used as intermediates for the antiscolic Triclabendazole.

4,5-Dichloro-2-nitroaniline Safety Profile

Hazard Codes: Xn
Risk Statements: 20/21/22-36/37/38
20/21/22:  Harmful by inhalation, in contact with skin and if swallowed 
36/37/38:  Irritating to eyes, respiratory system and skin 
Safety Statements: 26-37/39-36/37/39-22
26:  In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 
37/39:  Wear suitable gloves and eye/face protection 
36/37/39:  Wear suitable protective clothing, gloves and eye/face protection 
22:  Do not breathe dust 
RIDADR: 2811
WGK Germany: 3
Hazard Note: Harmful
HazardClass: 6.1(b)
PackingGroup: III

4,5-Dichloro-2-nitroaniline Specification

1. First Aid Measures
Ingestion:
Seek medical assistance.
Inhalation:
Move victim to fresh air. Apply artificial respiration if victim is not breathing. Do not use mouth-to-mouth method if victim ingested or inhaled the substance; induce artificial respiration with the aid of a pocket mask equipped with a one-way valve or other proper respiratory medical device. Administer oxygen if breathing is difficult.
Skin:
Remove and isolate contaminated clothing and shoes. Immediately flush with running water for at least 20 minutes. For minor skin contact, avoid spreading material on unaffected skin.
Eyes:
Immediately flush with running water for at least 20 minutes.
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