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Cas Database |
| Name |
4-Bromo-2-Fluorobenzaldehyde |
EINECS | 298-056-6 |
| CAS No. | 57848-46-1 | Density | 1.67 g/cm3 |
| PSA | 17.07000 | LogP | 2.40070 |
| Solubility | Insoluble in water | Melting Point |
59-64 °C |
| Formula | C7H4BrFO | Boiling Point | 241.4 °C at 760 mmHg |
| Molecular Weight | 203.011 | Flash Point | 99.8 °C |
| Transport Information | N/A | Appearance | light yellow to beige crystalline crystals |
| Safety | 37/39-26-36 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
4-bromo-2-fluoro-benzaldehyde;2-fluoro-4-bromobenzaldehyde;2-bromo-4-fluorobenzaldehyde; |
Article Data | 10 |
4-Bromo-2-Fluorobenzaldehyde Synthetic route
- 1435-52-5
2,5-dibromofluorobenzene
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| Stage #1: 2,5-dibromofluorobenzene With tri-n-butyllithium magnesate complex In tetrahydrofuran; toluene at 0℃; for 1h; Stage #2: N,N-dimethyl-formamide In toluene at 0℃; for 0.5h; Stage #3: With citric acid at 20℃; | 92% |
| Stage #1: 2,5-dibromofluorobenzene With n-butyllithium In diethyl ether at -100℃; for 0.75h; Stage #2: N,N-dimethyl-formamide In diethyl ether at -90℃; for 0.25h; Stage #3: With sulfuric acid In diethyl ether; water at -50℃; | 86% |
| Stage #1: 2,5-dibromofluorobenzene With isopropylmagnesium bromide In tetrahydrofuran at 0 - 5℃; for 1.5h; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran; toluene at 0 - 5℃; for 4h; Stage #3: With acetic acid In tetrahydrofuran; water; toluene at 0 - 10℃; |
- 188582-62-9
4-bromo-2-fluorobenzyl alcohol
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| With tert.-butylhydroperoxide; tetrabutylammomium bromide In decane; benzene at 40℃; for 24h; Inert atmosphere; Sealed tube; chemoselective reaction; | 87% |
- 1435-52-5
2,5-dibromofluorobenzene
- 693-04-9
butyl magnesium bromide
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| With n-butyllithium; acetic acid In tetrahydrofuran; hexane; N,N-dimethyl-formamide; toluene | 82% |
- 222978-01-0
4-bromo-3-fluorobenzyl alcohol
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| With sodium acetate; pyridinium chlorochromate In dichloromethane at 20℃; for 2h; | 63% |
| With sodium acetate; pyridinium chlorochromate In dichloromethane at 20℃; for 2h; light protection; | 63% |
- 877129-98-1
N-(4-bromo-2-fluoro-benzyl)-acetamide
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| With N-Bromosuccinimide In chloroform at 20℃; for 18h; | 51% |
| Conditions | Yield |
|---|---|
| With acetic anhydride In ethanol; water; acetic acid |
- 202865-64-3
4-bromo-2-fluorobenzaldehyde oxime
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| With acetic anhydride In ethanol at 140℃; |
- 1073-06-9
3-fluorobromobenzene
- 68-12-2, 33513-42-7
N,N-dimethyl-formamide
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| Stage #1: 3-fluorobromobenzene With lithium diisopropyl amide In tetrahydrofuran at -78℃; Stage #2: N,N-dimethyl-formamide In tetrahydrofuran |
- 153556-42-4
4-bromo-3-fluorobenzoic acid
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C 2: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 2 steps 1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice 2: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / light protection View Scheme |
- 452-74-4
4-bromo-3-fluorotoluene
- 57848-46-1
4-bromo-2-fluorobenzaldehyde
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: pyridine; water; potassium permanganate / 3 h / 90 °C 1.3: pH 2 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C 3.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C View Scheme | |
| Multi-step reaction with 3 steps 1.1: potassium permanganate / pyridine; water / 3 h / 90 °C 1.2: pH 2 1.3: pH 2 2.1: sodium tetrahydroborate; boron trifluoride diethyl etherate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice 3.1: sodium acetate; pyridinium chlorochromate / dichloromethane / 2 h / 20 °C / light protection View Scheme |
4-Bromo-2-Fluorobenzaldehyde Chemical Properties
Structure of 4-Bromo-2-Fluorobenzaldehyde (CAS NO.57848-46-1):
IUPAC Name: 4-bromo-2-fluorobenzaldehyde
Empirical Formula: C7H4BrFO
Molecular Weight: 203.0085
Index of Refraction: 1.584
Molar Refractivity: 40.68 cm3
Molar Volume: 121.4 cm3
Polarizability: 16.13×10-24cm3
Surface Tension: 42.3 dyne/cm
Density: 1.67 g/cm3
Flash Point: 99.8 °C
Enthalpy of Vaporization: 47.84 kJ/mol
Melting Point: 59-64 °C
Boiling Point: 241.4 °C at 760 mmHg
Vapour Pressure: 0.036 mmHg at 25°C
Water Solubility: INSOLUBLE
Sensitive: Air Sensitive
Physical Appearance: light yellow to beige crystal
Product Categories: Fluorin-contained benzaldehyde series;FINE Chemical & INTERMEDIATES;Fluorobenzene;Aromatic Aldehydes & Derivatives (substituted);Benzene series;Benzaldehyde;Miscellaneous;Adehydes, Acetals & Ketones;Bromine Compounds;Fluorine Compounds;Benzaldehyde (Building Blocks for Liquid Crystals);Building Blocks for Liquid Crystals;Functional Materials;Aldehydes;C7;Carbonyl Compounds
4-Bromo-2-Fluorobenzaldehyde Uses
4-Bromo-2-Fluorobenzaldehyde (CAS NO.57848-46-1) is used as intermediates in synthesis pharmaceutical and pesticide .
4-Bromo-2-Fluorobenzaldehyde Safety Profile
Hazard Codes: 
Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 37/39-26-36
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
Hazard Note: Irritant
HazardClass: IRRITANT, AIR SENSITIVE
4-Bromo-2-Fluorobenzaldehyde Specification
4-Bromo-2-Fluorobenzaldehyde , its cas register number is 57848-46-1. It also can be called Benzaldehyde, 4-bromo-2-fluoro- ; 2-Fluoro-4-bromobenzaldehyde ; 4-Bromo-2-Fluorobenzaldehyde2-Fluoro-4-Bromobenzaldehyde .
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