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Name	4-Bromo-5-Fluoro-2-Nitrotoluene	EINECS	218-838-2
CAS No.	224185-19-7	Density	1.696 g/cm³
PSA	45.82000	LogP	3.32800
Solubility	N/A	Melting Point	59-63 °C
Formula	C₇H₅BrFNO₂	Boiling Point	266.6 °C at 760 mmHg
Molecular Weight	234.025	Flash Point	115.1 °C
Transport Information	N/A	Appearance	N/A
Safety	26-36/37-36	Risk Codes	22-36-36/37/38
Molecular Structure		Hazard Symbols	Xn, Xi
Synonyms	1-Bromo-2-fluoro-4-methyl-5-nitrobenzene;	Article Data	10

4-Bromo-5-Fluoro-2-Nitrotoluene Synthetic route

: 452-74-4
4-bromo-3-fluorotoluene

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; potassium nitrate at 0 - 20℃;	100%
With sulfuric acid; potassium nitrate at 0℃;	100%
With sulfuric acid; nitric acid at 0℃;	92%

: 259860-00-9
2-fluoro-4-methyl-5-nitro-phenylamine

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

Conditions

Conditions	Yield
Stage #1: 2-fluoro-4-methyl-5-nitro-phenylamine With hydrogen bromide; sodium nitrite In water at 0 - 5℃; for 0.25h; Stage #2: With copper(I) oxide; hydrogen bromide In water at 0℃;	91%

: 446-33-3
3-fluoro-6-nitrotoluene

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

Conditions

Conditions	Yield
With sulfuric acid; bromine; silver nitrate In (2S)-N-methyl-1-phenylpropan-2-amine hydrate	83%

: 7787-70-4
copper(I) bromide

: 259860-00-9
2-fluoro-4-methyl-5-nitro-phenylamine

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

Conditions

Conditions	Yield
With sodium nitrite In water; hydrogen bromide	50%

: 141-52-6
sodium ethanolate

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 1226903-38-3
1-bromo-2-ethoxy-4-methyl-5-nitrobenzene

Conditions

Conditions	Yield
With sodium ethanolate In ethanol at 20℃; for 1h;	99%

: 1002309-52-5
1-methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyridin-2-one

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 5-(2-fluoro-4-methyl-5-nitrophenyl)-1-methylpyridin-2(1H)-one

Conditions

Conditions	Yield
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 0.5h; Suzuki Coupling; Inert atmosphere; Microwave irradiation;	99%
With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate In 1,2-dimethoxyethane; water at 120℃; for 0.5h; Inert atmosphere; Microwave irradiation;	99%

: 367-27-1
2,4-difluorophenol

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 1-bromo-2-(2,4-difluorophenoxy)-4-methyl-5-nitrobenzene

Conditions

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 20℃;	99%
With caesium carbonate In dimethyl sulfoxide at 100℃; for 3h;	3.8 g

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 627871-16-3
5-bromo-4-fluoro-2-methylaniline

Conditions

Conditions	Yield
With 2,3-dimethyl-2,3-butane diol; [MoO2Cl2(dmf)2] In o-xylene at 130℃; for 3h; chemoselective reaction;	95%
With iron; ammonium chloride In water for 48.5h; Heating / reflux;	72%
With ammonium chloride; iron In water for 48h; Heating / reflux;	72%

: 73183-34-3
bis(pinacol)diborane

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 1510828-68-8
2-(2-fluoro-4-methyl-5-nitrophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Conditions

Conditions	Yield
With [1,1'-bis(diphenylphosphino)-ferrocene]palladium(II) chloride-dichlormethane complex; potassium acetate In 1,4-dioxane at 100℃; for 1h; Suzuki Coupling; Inert atmosphere; Sealed tube;	91%
With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate In 1,4-dioxane at 90℃; for 15h; Inert atmosphere;

: 67-56-1
methanol

: 224185-19-7
3-bromo-4-fluoro-6-methylnitrobenzene

: 861076-28-0
1-bromo-2-methoxy-4-methyl-5-nitrobenzene

Conditions

Conditions	Yield
Stage #1: methanol With sodium at 0℃; for 0.5h; Stage #2: 3-bromo-4-fluoro-6-methylnitrobenzene at 30℃; for 2h;	87.8%
With sodium at 40℃; for 2h; Cooling with ice;

4-Bromo-5-Fluoro-2-Nitrotoluene Chemical Properties

4-Bromo-5-Fluoro-2-Nitrotoluene(224185-19-7) is also named as 2-Nitro-4-Bromo-5-Fluorotoluene;1-Bromo-2-fluoro-4-methyl-5-nitro-benzene,and so on.

CAS: 224185-19-7
Molecular Formula: C₇H₅BrFNO₂
Molecular Weight: 234.02
Molecular structure:
Melting point: 59-63°C
Index of Refraction: 1.57
Molar Refractivity: 45.3 cm³
Molar Volume: 137.9 cm³
Polarizability: 17.96 10^-24cm³
Surface Tension: 45.3 dyne/cm
Density: 1.696 g/cm³
Flash Point: 115.1 °C
Enthalpy of Vaporization: 48.43 kJ/mol
Boiling Point: 266.6 °C at 760 mmHg
Vapour Pressure: 0.0141 mmHg at 25°C

4-Bromo-5-Fluoro-2-Nitrotoluene Uses

4-Bromo-5-Fluoro-2-Nitrotoluene(224185-19-7) is commonly used as pharmaceutical intermediate.

4-Bromo-5-Fluoro-2-Nitrotoluene Safety Profile

Hazard Codes: Xn,Xi
Risk Statements: 22-36-36/37/38 (22: Harmful if swallowed 36: Irritating to the eyes 36/37/38: Irritating to eyes, respiratory system and skin)
Safety Statements: 26-36/37-36 (26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice 36/37: Wear suitable protective clothing and gloves 36: Wear suitable protective clothing)
WGK Germany: 3
Hazard Note: Irritant

4-Bromo-5-Fluoro-2-Nitrotoluene Specification

Removal In Wastewater Treatment of 4-Bromo-5-Fluoro-2-Nitrotoluene(224185-19-7) can be stated as follows:
Total removal: 14.36 percent
Total biodegradation: 0.17 percent
Total sludge adsorption: 11.60 percent
Total to Air: 2.58 percent
(using 10000 hr Bio P,A,S)

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