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Name	5-(Chloromethyl)-8-quinolinol	EINECS	N/A
CAS No.	4053-45-6	Density	1.355g/cm³
PSA	33.12000	LogP	3.48120
Solubility	N/A	Melting Point	280 °C (decomp)
Formula	C₁₀H₈ClNO	Boiling Point	388.1 °C at 760 mmHg
Molecular Weight	230.094	Flash Point	188.5 °C
Transport Information	N/A	Appearance	N/A
Safety		Risk Codes	22
Molecular Structure		Hazard Symbols
Synonyms	5-(CHLOROMETHYL)QUINOLIN-8-OL HYDROCHLORIDE;5-(CHLOROMETHYL)-8-QUINOLINOL HYDROCHLORIDE;IFLAB-BB F2124-0006;TIMTEC-BB SBB000700;5-(Chloromethyl)-8-hydroxyquinoline hydrochloride;8-quinolinol, 5-(chloromethyl)-;5-(Chloromethyl)-8-quinolinol;8-Quinolinol, 5-(chloromethyl)-, hydrochloride	Article Data	42

5-(Chloromethyl)-8-quinolinol Synthetic route

: 148-24-3
8-quinolinol

: 50-00-0
formaldehyd

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

Conditions

Conditions	Yield
With hydrogenchloride In water at 0 - 20℃; for 4h;	99%
With hydrogenchloride In water at 0 - 20℃; for 8h;	98%
With hydrogenchloride In water at 0 - 20℃; for 8h; Product distribution / selectivity;	98%

: 7647-01-0
hydrogenchloride

: 148-24-3
8-quinolinol

: 50-00-0
formaldehyd

: 7732-18-5
water

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 4053-44-5
5-(hydroxymethyl)-8-hydroxyquinoline

Conditions

Conditions	Yield
With ammonium hydroxide In diethyl ether	99.99%
With ammonium hydroxide In water at 20℃; for 0.25h; pH=9 - 10;	99%
With ammonia In water	86%
With ammonium hydroxide Substitution;

: 67-56-1
methanol

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 7545-59-7
5-methoxymethyl-8-hydroxy-7-quinoline

Conditions

Conditions	Yield
With sodium hydrogencarbonate Heating;	99%
Stage #1: methanol; 5-chloromethyl-8-hydroxyquinoline hydrochloride for 2h; Inert atmosphere; Reflux; Stage #2: With ammonium hydroxide In diethyl ether; water pH=8 - 10;	88%
Stage #1: methanol; 5-chloromethyl-8-hydroxyquinoline hydrochloride Reflux; Stage #2: With ammonium hydroxide In diethyl ether	42%
With sodium hydrogencarbonate for 2h; Reflux;

: 7755-92-2
piperazine-1-carbaldehyde

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 5-(4-formylpiperazinomethyl)-8-hydroxyquinoline

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In chloroform for 48h;	95%

: 27757-85-3
2-Aminomethylthiophene

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 1215290-42-8
JLK 1535

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 50℃; for 24h;	95%

: 1197-17-7, 1197-18-8, 701-54-2
4-aminomethyl-cyclohexanecarboxylic acid

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 1215290-47-3
4-((bis((8-hydroxyquinolin-5-yl)methyl)amino)methyl)-cyclohexanecarboxylic acid

Conditions

Conditions	Yield
With potassium carbonate In acetonitrile at 50℃; for 24h;	95%

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 5-((aminooxy)methyl)quinolin-8-ol

Conditions

Conditions	Yield
With hydroxylamine; sodium hydrogencarbonate In tetrahydrofuran Reflux;	94%

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 142-84-7
di-n-propylamine

: 7545-63-3
5-dipropylaminomethyl-quinolin-8-ol

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.416667h;	93%

: 4053-45-6
5-chloromethyl-8-hydroxyquinoline hydrochloride

: 122-39-4
diphenylamine

: 1065474-08-9
5-((diphenylamino)methyl)-quinolin-8-ol

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 0.416667h;	91%
With triethylamine In dichloromethane at 20℃;

5-(Chloromethyl)-8-quinolinol Chemical Properties

IUPAC Name: 5-(Chloromethyl)quinolin-8-ol
CAS NO: 4053-45-6
Molecular Formula: C₁₀H₈ClNO
Molecular Weight: 193.6296
Molecular Structure:
H bond acceptors: 2
H bond donors: 1
Freely Rotating Bonds: 2
Polar Surface Area: 22.12 Å²
Index of Refraction: 1.677
Molar Refractivity: 53.83 cm³
Molar Volume: 142.8 cm³
Surface Tension: 58.6 dyne/cm
Density: 1.355 g/cm³
Flash Point: 188.5 °C
Enthalpy of Vaporization: 66.22 kJ/mol
Boiling Point: 388.1 °C at 760 mmHg
Vapour Pressure: 1.41E-06 mmHg at 25°C
SMILES: ClCc1ccc(O)c2ncccc12
InChI: InChI=1/C10H8ClNO/c11-6-7-3-4-9(13)10-8(7)2-1-5-12-10/h1-5,13H,6H2
InChIKey: JGOBHUWKRDXZEY-UHFFFAOYAW
Std. InChI: InChI=1S/C10H8ClNO/c11-6-7-3-4-9(13)10-8(7)2-1-5-12-10/h1-5,13H,6H2
Std. InChIKey: JGOBHUWKRDXZEY-UHFFFAOYSA-N

5-(Chloromethyl)-8-quinolinol Safety Profile

Safety Information about 5-(Chloromethyl)-8-quinolinol (CAS NO.4053-45-6):
Hazard Codes: Irritant Xi

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