- 36070-83-42-Pyrazinecarboxylicacid, 5-bromo-, ethyl ester
- 3607-17-8Phosphonium,(3-bromopropyl)triphenyl-, bromide (1:1)
- 36072-16-9Propanenitrile,3-[(2,5-dimethylphenyl)amino]-
- 36073-93-5Isoquinoline, 4-nitro-
- 36075-68-0Quinoline,4-bromo-8-methyl-
- 360762-48-72H-1-Benzopyran-2-one,3-[(E)-[(4-chlorophenyl)imino]methyl]-4-hydroxy-
- 36076-26-31,4-Benzenediaceticacid, 1,4-diethyl ester
- 3607-78-11,1,1,3,3,3-Hexachloropropane
- 360791-53-31H-Indole-3-propanamide,a-amino-N-(2-furanylmethyl)-, (aS)-
- 36082-50-55-Bromo-2,4-dichloropyrimidine
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
5-Chloropyrazine-2-carboxylic acid |
EINECS | 636-844-7 |
| CAS No. | 36070-80-1 | Density | 1.579 g/cm3 |
| PSA | 63.08000 | LogP | 0.82820 |
| Solubility | N/A | Melting Point |
150-151℃ |
| Formula | C5H3ClN2O2 | Boiling Point | 330.9 °C at 760 mmHg |
| Molecular Weight | 158.544 | Flash Point | 153.9 °C |
| Transport Information | N/A | Appearance | light yellow solid powder |
| Safety | Risk Codes |
 Xi:; |
|
| Molecular Structure |
|
Hazard Symbols |
 Xi
|
| Synonyms |
Pyrazinecarboxylicacid, 5-chloro- (9CI);5-Chloropyrazinoicacid; |
Article Data | 20 |
5-Chloropyrazine-2-carboxylic acid Synthetic route
- 33332-25-1
methyl 5-chloropyrazine-2-carboxylate
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| With potassium carbonate In tetrahydrofuran; water at 25℃; for 42h; | 96% |
| Stage #1: methyl 5-chloropyrazine-2-carboxylate With methanol; sodium hydroxide; water In tetrahydrofuran at 0 - 20℃; for 5h; Stage #2: With hydrogenchloride In tetrahydrofuran; methanol; water | 92% |
| With hydrogenchloride; potassium carbonate In tetrahydrofuran; water | 91% |
- 34604-60-9
5-hydroxypyrazinoic acid
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| With thionyl chloride In N,N-dimethyl-formamide at 80℃; for 16h; | 93% |
| With thionyl chloride; N,N-dimethyl-formamide for 16h; Reflux; | 75% |
| Multi-step reaction with 2 steps 1: thionyl chloride; N,N-dimethyl-formamide / 4 h / 75 °C 2: water View Scheme |
- 34604-60-9
4,5-dihydro-5-oxo-2-pyrazinecarboxylic acid
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| With phosphorus pentachloride In toluene at 80℃; for 2h; Large scale; | 85.6% |
- 82619-63-4
2-chloro-5-furan-2-yl-pyrazine
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| With potassium permanganate; Aliquat 336 In water; benzene at 0 - 40℃; for 4h; | 78% |
| With potassium permanganate; Aliquat 336 In water; benzene at 15 - 20℃; for 4.5h; | 76% |
- 82619-62-3
2-Hydroxy-5-(2'-furyl)pyrazine
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1: 52 percent / POCl3 / 3 h / Heating 2: 76 percent / KMnO4 / tricaprylmethylammonium chloride / benzene; H2O / 4.5 h / 15 - 20 °C View Scheme |
- 33332-25-1
methyl 5-chloropyrazine-2-carboxylate
- 111-27-3
hexan-1-ol
A
- 668972-67-6
5-(hexyloxy)pyrazine-2-carboxylic acid
B
- 668972-68-7
hexyl 5-hexyloxypyrazine-2-carboxylate
C
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| Stage #1: hexan-1-ol With sodium at 60℃; for 0.75h; Stage #2: methyl 5-chloropyrazine-2-carboxylate at 50℃; for 0.583333h; |
- 88625-23-4
5-chloropyrazine-2-carbonyl chloride
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| With water |
- 57005-60-4
1,6-dihydro-6-oxo-2,3-pyrazinedicarbonitrile
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: sodium hydroxide / water / 6 h / 100 °C / Large scale 2.1: Aliquat 336 / sulfolane; toluene / 2.5 h / 150 °C / Dean-Stark; Large scale 2.2: Large scale 3.1: phosphorus pentachloride / toluene / 2 h / 80 °C / Large scale View Scheme |
- 36070-80-1
5-chloropyrazinoic acid
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: Aliquat 336 / sulfolane; toluene / 2.5 h / 150 °C / Dean-Stark; Large scale 1.2: Large scale 2.1: phosphorus pentachloride / toluene / 2 h / 80 °C / Large scale View Scheme |
- 36070-80-1
5-chloropyrazinoic acid
- 34604-60-9
5-hydroxypyrazinoic acid
| Conditions | Yield |
|---|---|
| With sodium hydroxide for 1h; Heating; | 100% |
5-Chloropyrazine-2-carboxylic acid Chemical Properties
Product Name: 5-chloro-2-Pyrazinecarboxylic acid (CAS NO.36070-80-1)
Molecular Formula: C5H3ClN2O2
Molecular Weight: 158.54252g/mol
Mol File: 36070-80-1.mol
Boiling point: 330.9 °C at 760 mmHg
Flash Point: 153.9 °C
Density: 1.579 g/cm3
Surface Tension: 73.2 dyne/cm
Enthalpy of Vaporization: 60.53 kJ/mol
Vapour Pressure: 6.48E-05 mmHg at 25°C
XLogP3-AA: 0.1
H-Bond Donor: 1
H-Bond Acceptor: 4
Structure Descriptors of 5-chloro-2-Pyrazinecarboxylic acid (CAS NO.36070-80-1):
IUPAC Name: 5-chloropyrazine-2-carboxylic acid
Canonical SMILES: C1=C(N=CC(=N1)Cl)C(=O)O
InChI: InChI=1S/C5H3ClN2O2/c6-4-2-7-3(1-8-4)5(9)10/h1-2H,(H,9,10)
InChIKey: FXJOTWLLDJYKAG-UHFFFAOYSA-N
Product Categories: Piperazine series; API intermediates; Pyrazines; Carboxylic Acids; Pyrazines, Pyrimidines & Pyridazines
5-Chloropyrazine-2-carboxylic acid Safety Profile
Safety Information of 5-chloro-2-Pyrazinecarboxylic acid (CAS NO.36070-80-1):
Hazard Codes: Xi
HazardClass: IRRITANT
5-Chloropyrazine-2-carboxylic acid Specification
5-chloro-2-Pyrazinecarboxylic acid , its CAS NO. is 36070-80-1, the synonyms are 5-Chloropyrazinoic acid ; Pyrazinecarboxylic acid, 5-chloro- .
What can I do for you?
Get Best Price
