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| Name |
Becaplermin |
EINECS | N/A |
| CAS No. | 165101-51-9 | Density | N/A |
| PSA | 0.00000 | LogP | 0.00000 |
| Solubility | N/A | Melting Point |
N/A |
| Formula | N/A | Boiling Point | N/A |
| Molecular Weight | 0.00000 | Flash Point | N/A |
| Transport Information | N/A | Appearance | N/A |
| Safety | Risk Codes | N/A | |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
RWJ 60235;Regranex;Platelet-derived growth factor BB, recombinant;RWJ 60235;Regranex Gel 0.1%;UNII-1B56C968OA;rPDGF-BB;rhPDGF-BB; |
Becaplermin Specification
1. Introduction of Becaplermin
Becaplermin (brand name Regranex) is a cicatrizant, available as a topical gel. Becaplermin is one kind of Topical wound healing drug Action/Kinetics. The Classification Code of this chemical is Angiogenesis Inducing Agents; Angiogenesis Modulating Agents; Chronic dermal ulcers treatment (promotes the proliferation of mesenchymally-derived cells); Growth Substances; Promotes the proliferation of mesenchymally-derived cells.
2. Toxicity of Becaplermin
Toxicity data about Becaplermin:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| monkey | LD | subcutaneous | > 3mg/kg (3mg/kg) | American Journal of Surgery. Vol. 176(2A), Pg. 55, 1998. | |
| mouse | LD | intravenous | > 30mg/kg (30mg/kg) | BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) | American Journal of Surgery. Vol. 176(2A), Pg. 55, 1998. |
| mouse | LD | subcutaneous | > 3mg/kg (3mg/kg) | American Journal of Surgery. Vol. 176(2A), Pg. 55, 1998. | |
| rat | LD | intravenous | > 3mg/kg (3mg/kg) | American Journal of Surgery. Vol. 176(2A), Pg. 55, 1998. | |
| rat | LD | subcutaneous | > 3mg/kg (3mg/kg) | American Journal of Surgery. Vol. 176(2A), Pg. 55, 1998. |
3. Uses of Becaplermin
Becaplermin, as adjunct to good ulcer care practices, treat lower extremity diabetic neuropathic ulcers that extend into SC tissue or beyond and have adequate blood supply. Becaplermin usually used for diabetic neuropathic ulcers that do not extend through dermis into SC tissue or ischemic ulcers has not been studied.
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