Related Products
- 51229-78-83,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane,1-[(2Z)-3-chloro-2-propen-1-yl]-, chloride (1:1)
- 5122-99-64-Iodophenylboronic Acid
- 51234-28-75-Benzoxazoleaceticacid, 2-(4-chlorophenyl)-a-methyl-
- 51234-92-52-[2-(4-Nitrophenyl)benzooxazol-5-yl]propanoic acid
- 51234-98-1Carbamicacid, N-cyano-, methyl ester, sodium salt (1:1)
- 51235-04-21,3,5-Triazine-2,4(1H,3H)-dione,3-cyclohexyl-6-(dimethylamino)-1-methyl-
- 5123-55-72H-Isoindole-2-aceticacid, 1,3-dihydro-1,3-dioxo-a-(phenylmethyl)-, (aS)-
- 51240-95-0Neodecaneperoxoic acid,1,1,3,3-tetramethylbutyl ester
- 51-24-1Benzeneacetic acid,4-(4-hydroxy-3-iodophenoxy)-3,5-diiodo-
- 512-42-5Sulfuric acid,monomethyl ester, sodium salt (1:1)
Hot Products
- 104987-11-3Tacrolimus
- 141-53-7Sodium formate
- 8001-54-5Quaternary ammonium compounds, alkylbenzyldimethyl, chlorides
- 9003-39-8Povidone
- 10161-34-9Trenbolone acetate
- 402957-28-2Telaprevir
- 68-19-9Cyanocobalamin
- 7631-86-9Silicon dioxide
- 302-79-4Tretinoin
- 77-92-9Citric acid
|
Basic Information |
|
Post buying leads |
|
Suppliers |
|
Cas Database |
| Name |
Biphenyl-3-boronic acid |
EINECS | -0 |
| CAS No. | 5122-95-2 | Density | 1.18 g/cm3 |
| PSA | 40.46000 | LogP | 1.03340 |
| Solubility | Insoluble in water. | Melting Point |
193-198 °C(lit.) |
| Formula | C12H11BO2 | Boiling Point | 411 °C at 760 mmHg |
| Molecular Weight | 198.029 | Flash Point | 202.3 °C |
| Transport Information | N/A | Appearance | yellow crystal powder |
| Safety | 37/39-26 | Risk Codes | 36/37/38 |
| Molecular Structure |
|
Hazard Symbols |
 Xi, C
|
| Synonyms |
Biphenyl-3-bronic acid;biphenyl-3-ylboronic acid;3-Biphenylboronic acid; |
Article Data | 12 |
Biphenyl-3-boronic acid Synthetic route
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-bromobiphenyl With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 2h; Stage #2: Trimethyl borate In tetrahydrofuran at -78 - 20℃; Stage #3: With hydrogenchloride In tetrahydrofuran at 20℃; for 2h; Further stages.; | 75% |
| With hydrogenchloride; n-butyllithium In tetrahydrofuran soln. of n-BuLi in hexanes added dropwise to soln. of biphenyl compd. at-78°C under Ar, kept at this temp. for 2 h, soln. of borate adde d over 30 min, allowed to warm to room temp. overnight, 10% aq. HCl added, stirred for 2 h at room temp.; extd. into Et2O, washed with concd. soln. of Na2CO3 then with H2O, evapd., recrystd. twice from H2O/EtOH (95/5); | 75% |
| Stage #1: 3-bromobiphenyl With n-butyllithium In tetrahydrofuran; hexane at -78℃; for 1h; Inert atmosphere; Stage #2: Trimethyl borate In tetrahydrofuran; hexane for 24h; | 65% |
| With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane BuLi soln. (hexane) addn. to biphenylbromide soln. (THF), mixt. stirring1 h, mixt. addn. to B-compd. soln. (THF) via canula (N2) at -78° C., stirring 1 h, gradual warming to room temp., aq. HCl addn., stirringat room temp. 15 h, solvent removal; under reduced pressure, Et2O addn., org. layer sepn., drying (MgSO4), soln. concn.. oil triturating with hexane, solid repptn. from MeOH/H2O; | 43% |
| With hydrogenchloride; tert.-butyl lithium In water; pentane |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-bromobiphenyl With n-butyllithium In tetrahydrofuran; hexane at -80℃; for 1h; Inert atmosphere; Stage #2: With Trimethyl borate In tetrahydrofuran; hexane at -80 - 20℃; for 4h; Stage #3: With hydrogenchloride; water In tetrahydrofuran; hexane for 2h; | 55% |
| Multi-step reaction with 2 steps 1.1: n-BuLi / -78 °C 1.2: -78 - 20 °C 2.1: aq. HCl View Scheme | |
| Stage #1: 3-bromobiphenyl With magnesium In tetrahydrofuran Stage #2: With Trimethyl borate Stage #3: With hydrogenchloride Further stages.; |
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride; n-butyllithium In tetrahydrofuran; hexane BuLi soln. (hexane) addn. to biphenylbromide soln. (THF), mixt. stirring1 h, mixt. addn. to B-compd. soln. (THF) via canula (N2) at -78° C., stirring 1 h, gradual warming to room temp., aq. HCl addn., stirringat room temp. 15 h, solvent removal; under reduced pressure, Et2O addn., org. layer sepn., drying (MgSO4), soln. concn.. oil triturating with hexane, solid repptn. from MeOH/H2O; | 40% |
- 688-74-4
boric acid tributyl ester
- 103068-18-4
[(1,1'-biphenyl)-3-yl]magnesium bromide
- 5122-95-2
3-Biphenylboronic acid
Conditions
| Conditions | Yield |
|---|---|
| With diethyl ether at -70℃; und anschliessenden Hydrolyse; |
- 5122-95-2
3-Biphenylboronic acid
Conditions
| Conditions | Yield |
|---|---|
| With hydrogenchloride |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: Pd(PPh3)4; Na2CO3 / 1,2-dimethoxy-ethane / 80 °C 2.1: n-BuLi / -78 °C 2.2: -78 - 20 °C 3.1: aq. HCl View Scheme | |
| Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 3 h / 90 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: 24 h View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 3 steps 1.1: Pd(PPh3)4; Na2CO3 / 1,2-dimethoxy-ethane / 80 °C 2.1: n-BuLi / -78 °C 2.2: -78 - 20 °C 3.1: aq. HCl View Scheme |
Conditions
| Conditions | Yield |
|---|---|
| Stage #1: 3-bromobiphenyl With n-butyllithium In diethyl ether; hexane; toluene at -30 - 0℃; for 1h; Stage #2: Triisopropyl borate In diethyl ether; hexane; toluene at -70 - 20℃; for 1h; Stage #3: With hydrogenchloride; water In diethyl ether; hexane; toluene | |
| With tert.-butyl lithium In diethyl ether; pentane |
Conditions
| Conditions | Yield |
|---|---|
| Multi-step reaction with 2 steps 1.1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / toluene; ethanol / 3 h / 90 °C 2.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere 2.2: 24 h View Scheme |
- 1394235-81-4
9-bromo-N-(tert-butyl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
- 5122-95-2
3-Biphenylboronic acid
- 1410123-84-0
9-[(1-1’-biphenyl)-3-yl]-N-(tert-butyl)-3,4-dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine
Conditions
| Conditions | Yield |
|---|---|
| With tetrakis(triphenylphosphine) palladium(0); dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium carbonate In ethanol; water; toluene for 1h; Suzuki-Miyaura Coupling; Reflux; | 100% |
Biphenyl-3-boronic acid Chemical Properties
MF: C12H11BO2
MW: 198.03
Mol File: 5122-95-2.mol
mp: 193-198 °C(lit.)
storage temp:. 0-6°C
BRN : 2836311
CAS DataBase Reference: 5122-95-2(CAS DataBase Reference)
MW: 198.03
Mol File: 5122-95-2.mol
mp: 193-198 °C(lit.)
storage temp:. 0-6°C
BRN : 2836311
CAS DataBase Reference: 5122-95-2(CAS DataBase Reference)
Biphenyl-3-boronic acid Toxicity Data With Reference
1、RTECS#: CAS# 5122-95-2: None listed
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: Biphenyl-3-boronic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated.
2、LD50/LC50: RTECS: Not available.
3、Carcinogenicity: Biphenyl-3-boronic acid - Not listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.
4、Other: The toxicological properties have not been fully investigated.
Biphenyl-3-boronic acid Safety Profile
Hazard Codes: Xi,C
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
Hazard Note: Corrosive
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
Hazard Note: Corrosive
Biphenyl-3-boronic acid Specification
(1):Handling and Storage of 3-BIPHENYLBORONIC ACID
Handling: Avoid breathing dust, vapor, mist, or gas. Avoid contact with skin and eyes.
Storage: Store in a tightly closed container. Store in a dry area. Keep refrigerated(Store below 4°C/39°F.)
(2):Fire Fighting Measures of 3-BIPHENYLBORONIC ACID
General Information: As in any fire, wear a self-contained breathing apparatus in pressure-demand, MSHA/NIOSH (approved or equivalent), and full protective gear.
Extinguishing Media: Use water spray, dry chemical, carbon dioxide, or chemical foam.
Post a RFQ
1
What can I do for you?
Get Best Price
Get Best Price for 5122-95-2
Biphenyl-3-boronic acid
