Hot Products

Basic Information

Post buying leads

Suppliers

Cas Database

Name	Bis(2-oxo-3-oxazolidinyl)phosphinic chloride	EINECS	629-561-5
CAS No.	68641-49-6	Density	1.71 g/cm³
PSA	85.96000	LogP	1.11350
Solubility	Hydrolyzes with water.	Melting Point	191 °C (dec.)(lit.)
Formula	C₆H₈ClN₂O₅P	Boiling Point	332.8 °C at 760 mmHg
Molecular Weight	254.567	Flash Point	155.1 °C
Transport Information	UN 3261 8/PG 2	Appearance	White solid
Safety	26-36/37/39-45-27	Risk Codes	34
Molecular Structure		Hazard Symbols	C
Synonyms	Phosphinicchloride, bis(2-oxo-3-oxazolidinyl)- (9CI);BOP-Cl;BOPDC;NSC 377647;	Article Data	7

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Synthetic route

: 77349-88-3
C24H24ClN2O9P*C5H5N

: 62-53-3
aniline

A: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

B: 77331-11-4
Phenyl-acetic acid indan-5-yl ester

C: 59858-31-0
2,N-Diphenyl-malonamic acid indan-5-yl ester

Conditions

Conditions	Yield
	A 19% B 26% C 73%

: 497-25-6
dimethylenecyclourethane

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

Conditions

Conditions	Yield
With phosphorus pentachloride In nitromethane at 20℃; for 4h; phosphoramidation;	60%
With phosphorus pentachloride; water 1.) acetonitrile, 20-25 deg C, 24 h 2.) 15-20 deg C, 30 min; Yield given. Multistep reaction;
With phosphorus pentachloride; water 1.) nitromethane, 20-25 deg C, 4 h; 40-45 deg C, 2 h; 2.) nitromethane, 1,2-dimethoxyethane, 0 deg C, 5 min.; Yield given. Multistep reaction;
With phosphorus pentachloride; water 1.) MeCN, 24 h, room temp. 2.) MeCN, -5 deg C; Yield given. Multistep reaction;
With triethylamine; trichlorophosphate In tetrahydrofuran at 0 - 35℃; for 2h;

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: 109-73-9
N-butylamine

: 91775-41-6
C10H18N3O5P

Conditions

Conditions	Yield
In dichloromethane for 0.75h; Ambient temperature;	100%
With triethylamine In dichloromethane at 20 - 25℃; for 0.75h;	100%

: 4530-20-5
BOC-glycine

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: (R*)-N-[[2-[N-[(1,1-Dimethylethoxy)carbonyl]glycyl]-1,2,3,4-tetrahydro-3-isoquinolinyl]carbonyl]-L-methionine

Conditions

Conditions	Yield
With N-ethyl-N,N-diisopropylamine In dichloromethane	100%

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: 75-64-9
tert-butylamine

: 91775-43-8
C10H18N3O5P

Conditions

Conditions	Yield
In dichloromethane at 20 - 25℃; for 3.5h;	99%

: 15761-38-3
L-N-Boc-Ala

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: (R*)-N-[[2-[N-[(1,1-Dimethylethoxy)carbonyl]-L-alanyl]-1,2,3,4-tetrahydro-3-isoquinolinyl]carbonyl]-L-methionine

Conditions

Conditions	Yield
With hydrogenchloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dimethylsulfide; dichloromethane	99%

: t-Butyloxycarbonyl-L-1,2,3,4-tetrahydroisoquinolin-3-carboxylic acid

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: (R*)-N-[[2-[(1,1-Dimethylethoxy)carbonyl]-1,2,3,4-tetrahydro-3-isoquinolinyl]carbonyl]-N-methyl-L-methionine

Conditions

Conditions	Yield
With hydrogenchloride; N-ethyl-N,N-diisopropylamine In 1,4-dioxane; dimethylsulfide; dichloromethane	99%

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: 81592-01-0
2,6-dichlorobenzoic acid N-ethyl-piperidinium salt

: 77331-22-7
C13H11Cl2N2O7P

Conditions

Conditions	Yield
	98%

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: 50-30-6
2,6-dichlorobenzoic acid

: 77331-22-7
C13H11Cl2N2O7P

Conditions

Conditions	Yield
With 1-ethyl-piperidine In dichloromethane at 15℃; for 1.5h;	98%

: 1477517-16-0
C13H19BrO3Si

: 68641-49-6
bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride

: 1477517-17-1
C19H26BrN2O8PSi

Conditions

Conditions	Yield
With triethylamine In dichloromethane at 20℃; for 1h;	98%

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Chemical Properties

Molecule structure of Phosphinic chloride,P,P-bis(2-oxo-3-oxazolidinyl)- (CAS NO.68641-49-6):

IUPAC Name: 3-[chloro-(2-oxo-1,3-oxazolidin-3-yl)phosphoryl]-1,3-oxazolidin-2-one
Molecular Weight: 254.564881 [g/mol]
Molecular Formula: C₆H₈ClN₂O₅P
Index of Refraction: 1.572
Molar Refractivity: 48.79 cm³
Molar Volume: 148.2 cm³
Surface Tension: 67.6 dyne/cm
Density: 1.71 g/cm³
Melting Point: 191 °C (dec.)(lit.)
Flash Point: 155.1 °C
Enthalpy of Vaporization: 57.57 kJ/mol
Boiling Point: 332.8 °C at 760 mmHg
Vapour Pressure: 0.000142 mmHg at 25 °C
Sensitive Moisture: Sensitive
XLogP3-AA: -0.1
H-Bond Acceptor: 5
Rotatable Bond Count: 2
Exact Mass: 253.985936
MonoIsotopic Mass: 253.985936
Topological Polar Surface Area: 76.2
Heavy Atom Count: 15
Canonical SMILES: C1COC(=O)N1P(=O)(N2CCOC2=O)Cl
InChI: InChI=1S/C6H8ClN2O5P/c7-15(12,8-1-3-13-5(8)10)9-2-4-14-6(9)11/h1-4H2
InChIKey: KLDLRDSRCMJKGM-UHFFFAOYSA-N
Product Categories of Phosphinic chloride,P,P-bis(2-oxo-3-oxazolidinyl)- (CAS NO.68641-49-6): Peptide coupling agents; Coupling Reagent; Biochemistry; Condensation & Active Esterification; Coupling Reactions (Peptide Synthesis); Peptide Synthesis; Synthetic Organic Chemistry

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Safety Profile

Hazard Codes: Corrosive C
Risk Statements: 34
R34:Causes burns.
Safety Statements: 26-36/37/39-45-27
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S27:Take off immediately all contaminated clothing.
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
RTECS: SZ5871000
F: 10-21
HazardClass: 8
PackingGroup: II

Bis(2-oxo-3-oxazolidinyl)phosphinic chloride Specification

Phosphinic chloride,P,P-bis(2-oxo-3-oxazolidinyl)- (CAS NO.68641-49-6) is also called Bis(2-oxo-3-oxazolidinyl)phosphinic chloride ; BOP-Cl ; Phosphinic chloride, bis(2-oxo-3-oxazolidinyl)- ; Bis(2-oxo-1,3-oxazolidin-3-yl)phosphinic chloride .

Post a RFQ

Cas No.:

Product Name:

Quantity:

Email:

Company name:

Valid Period:

Detailed Requirements:

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

What can I do for you?
Get Best Price

Get Best Price for 68641-49-6