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Cas Database |
| Name |
Budipine |
EINECS | N/A |
| CAS No. | 57982-78-2 | Density | 1.009g/cm3 |
| PSA | 3.24000 | LogP | 4.80490 |
| Solubility | N/A | Melting Point |
108.5°C |
| Formula | C21H27 N | Boiling Point | 387.6°Cat760mmHg |
| Molecular Weight | 293.452 | Flash Point | 168.7°C |
| Transport Information | N/A | Appearance | N/A |
| Safety | Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx. | Risk Codes | N/A |
| Molecular Structure |
|
Hazard Symbols | N/A |
| Synonyms |
1-tert-Butyl-4,4-diphenylpiperidine;Budipine |
Article Data | 1 |
Budipine Synthetic route
| Conditions | Yield |
|---|---|
| With aluminium trichloride at 60℃; for 2h; Yield given; |
- 81831-81-4
(1-tert-butyl-4-hydroxy-4-phenyl-piperidin-3-yl)-phenyl-methanone
- 71-43-2
benzene
A
- 57982-78-2
budipine
| Conditions | Yield |
|---|---|
| With aluminium trichloride 1.) 45 deg C, 30 min, 2.) 50-55 deg C, 1 h; Yield given; |
Budipine Chemical Properties
Chemistry informtion about Budipine (CAS NO.57982-78-2) is:
IUPAC Name: 1-Tert-Butyl-4,4-Diphenylpiperidine
Synonyms: Budipine ; 1-(1,1-Dimethylethyl)-4,4-Diphenyl-Piperidin ; 1-(1,1-Dimethylethyl)-4,4-Diphenylpiperidine ; Budipin ; 1-Tert-Butyl-4,4-Diphenyl-Piperidine ; Budipine(Forr&Donly) ; 4,4-Diphenyl-1-Tert-Butyl-Piperidine
MF: C21H27N
MW: 293.45
EINECS: 261-062-4
Density: 1.009 g/cm3
Flash Point: 168.7 °C
Boiling Point: 387.6 °C at 760 mmHg
Vapour Pressure: 3.25E-06 mmHg at 25°C
Enthalpy of Vaporization: 63.67 kJ/mol
Following is the molecular structure of Budipine (CAS NO.57982-78-2) is:
Budipine Uses
Budipine (CAS NO.57982-78-2) is believed to be a NMDA receptor antagonist, and to promote the synthesis of dopamine. Because it provides additional benefits relative to existing treatments, it probably does not precisely mimic the mechanism of an existing known treatment.
Budipine Toxicity Data With Reference
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| mouse | LD50 | intravenous | 33mg/kg (33mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 85, 1982. | |
| mouse | LD50 | oral | 120mg/kg (120mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 85, 1982. | |
| rat | LD50 | intravenous | 28mg/kg (28mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 85, 1982. | |
| rat | LD50 | oral | 165mg/kg (165mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 32, Pg. 85, 1982. |
Budipine Safety Profile
Poison by ingestion and intravenous routes. When heated to decomposition it emits toxic fumes of NOx.
Budipine Specification
Budipine (CAS NO.57982-78-2) is a dopaminergic agent. Its mechanism is not well characterized.
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