- 4-[(3-chlorophenyl)diazenyl]-2-{[tris(hydroxymethyl)methyl]-aminomethyle ne}cyclohexa-3,5-dien-1(2H)-one
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The title compound, C17H18ClN3O4, adopts the keto-amine tautomeric form and displays an intramolecular N-H...O hydrogen bond [N...O = 2.639 (2) A]. The configuration around the azo N=N double bond is trans, and
- Odabasoglu, Mustafa,Albayrak, Cigdem,Bueyuekguengoer, Orhan,Goesmann, Helmut
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- Flow synthesis of ethyl isocyanoacetate enabling the telescoped synthesis of 1,2,4-triazoles and pyrrolo-[1,2-c]pyrimidines
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The efficient flow synthesis of important heterocyclic building blocks based on the 1,2,4-triazole and pyrrolo[1,2-c]pyrimidine scaffold has been achieved. Crucially, a telescoped continuous flow process was developed based on the reaction of N-formylglycine with triphosgene to deliver a stream of ethyl isocyanoacetate in situ, which subsequently yielded the desired heterocyclic entities in a telescoped reaction. Additionally, the functionalisation of the pyrrolo[1,2-c]pyrimidine core via subsequent SEAr reactions was studied revealing insight into a 'halogen dance' phenomenon associated with these medicinally relevant architectures. This journal is
- Baumann, Marcus,Rodriguez Garcia, Antonio M.,Baxendale, Ian R.
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p. 4231 - 4239
(2015/04/14)
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- TETRAZOLE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS
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The present invention relates to new compounds of formula (I) wherein Y1 and Y2 selected from the group consisting of hydrogen, halogen atom, C1-4 alkyl, C1-4 alkoxy or cyano group, X is oxygen or two hydrogen a
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Page/Page column 25
(2008/06/13)
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- TRIAZOLE COMPOUNDS AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR ANTAGONISTS
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The present invention relates to new compounds of formula (I), wherein P, Q, X1, X2, X3, X4 X7, X8, R1, R2, R3, m, n, and p are as defined as in formula (I)
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Page/Page column 45-46
(2010/02/13)
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- Synthesis of L-6-chloropyrroloindoline of chloptosin cyclohexapeptide
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Chloptosin is an apoptosis-inducing dimeric cyclohexapeptide. Enantio-selective synthesis of L-6-chloropyrroloindoline, as the key chiral synthon of the cyclohexapeptide of chloptosin, was successfully achieved starting from 3-chloroaniline by utilizing F
- Kim, Young-Ah,Han, So-Yeop
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p. 2931 - 2943
(2007/10/03)
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- Synthesis, characterization and antimicrobial studies of some novel 3- arylazo-7-hydroxy-4-methylcoumarins
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A series of 3-arylazo-7-hydroxy-4-methylcoumarins have been synthesized in excellent yields (80-90%) and their structures established on the basis of IR, 1H NMR, mass spectral data and elemental analyses. Their purity has been ascertained by ch
- Sharma, Pratibha,Pritmani, Shreeya
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p. 1139 - 1142
(2007/10/03)
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- Reaction of Triazene 1-Oxides: Novel Synthesis of Solid Arenediazonium Chlorides
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Treatment of 1,3-diaryltriazene 1-oxides with oxalyl chloride in dry toluene at room temperature gives only solid arenediazonium chlorides; however, treatment with acetyl and benzoyl chlorides does not afford the corresponding diazonium chlorides.
- Mohamed, Shaaban K.,Gomaa, Mohsen A.-M.,Nour El-Din, Ahmed M.
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p. 166 - 167
(2007/10/03)
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- Electrophilic Substitution of Diazonium Salts in 2-Amino-4-(alkyl or aryl)oxazoles
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Aryl diazonium fluoborates react readily with 2-amino-4-alkyloxazoles and 2-amino-4-aryloxazoles under mild conditions.The products are the corresponding 5-arylazo derivatives formed, in 44-98percent yield free from side products.
- Crank, George,Mekonnen, Belew
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p. 1469 - 1472
(2007/10/02)
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- The Influence of Chlorine and Sulphonate Substituents on the Visible Absorption Maxima of Some Azo Dyes
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A total of 110 arylazo dyes have been prepared, based on five benzenoid and heterocyclic coupling components, and containing combinations of chlorine and sulphonate (sulpho) substituents in the diazo components.Their visible absorption maxima have been analysed in order to determine the degree to which chloro and sulfo substituent influences are constant and transferable, both within a series, and between series.Additivity is found to pertain, if allowances are made for steric effects.A 2-sulpho group alone can induce nonplanarity, depending on the nature of the coupling component.The 2-sulpho-3-chloro combination is particularly responsible for hypsochromic shifts unexpected on the basis of strict additivity.Computer-aided molecular modelling studies have clarified the steric interactions present.Di-ortho-substitution also induces nonplanarity and hypsochromic effects.There is some evidence for non-equivalence of a substituent in the two distinct meta-orientations, although MO calculations do not reproduce this behaviour.
- Greenwood, David,Hutchings, Michael G.,Lamble, Brian
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p. 1107 - 1114
(2007/10/02)
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- Resonance Raman study of phenylhydrazonopropanedinitriles
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Resonance Raman spectra and band assignments of some phenylhydrazonopropanedinitriles, including the 3-chloro and the 2-carboxyderivatives, in the 900-2300 cm-1 spectral range are presented and discussed. 15N and 2H isotopic shifts have been us
- Merlin, Jean Claude,Thomas, Emrys W.,Petit, Guislaine
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p. 1840 - 1844
(2007/10/02)
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- USE OF CURRENTLESS POTENTIAL-TIME CURVES FOR DETERMINING THE RATE CONSTANTS OF DIAZOTATION REACTIONS
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The kinetics and the rate constants for the diazotation of nine aromatic amines at various conditions (temperature, medium) were determined by the method of currentless potential-time curves.A comparison with an independent method and with literature data is presented.
- Dlask, Vladimir
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p. 2315 - 2319
(2007/10/02)
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- Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides
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Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.
- Nagarajan, K.,Talwalker, P.K.,Kulkarni, C.L.,Venkateswarlu, A.,Prabhu, S.S.,Nayak, G.V.
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p. 1243 - 1257
(2007/10/02)
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- 1,2,3-Triazabutadienes. XIV. Investigations into the Acidic Cleavage of the Z-E-Isomeric 1-Aryl-3-- and 1-Aryl-3--triazenes
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The rate of the acid cleavage of the Z-E-isomeric 1-aryl-3-- and 1-aryl-3--triazenes 1 - 5 is investigated in dependence on the substituents in the aryl and benzo residue.The Z-isomer
- Fanghaenel, E.,Hohlfeld, J.
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p. 253 - 261
(2007/10/02)
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