cas 100418-33-5, 2-(4-Methyl-2-nitrophenylamino)ethanol | Articles data ｜lookchem

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100418-33-5

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Synthesis and biological evaluation of imidazoquinoxalinones, imidazole analogues of pyrroloiminoquinone marine natural products
This report describes the synthesis and biological activity of imidazoquinoxalines, benzimidazole-based analogues of indole-based pyrroloiminoquinone marine natural products. Our analogues consist of series 1, which possesses the ethylene tether and exten
Hoang, Hung,LaBarbera, Daniel V.,Mohammed, Kaleem A.,Ireland, Chris M.,Skibo, Edward B.
p. 4561 - 4571
(2008/03/12)

Synthesis of imidazo[1,5,4-de]quinoxalin-9-ones, benzimidazole analogues of pyrroloiminoquinone marine natural products
The imidazoquinoxalinones 1 and 2 are benzimidazole analogues of indole-based marine natural products called makaluvamins. The stabilized cation 1 and the zwitterion 2 were prepared in ～9 steps from readily available starting materials. Compound 1 is more cytostatic and cytotoxic than 2 and also shows activity in the hollow fiber assay. Unlike the indole-based natural products, 1 and 2 are not potent topoisomerase II inhibitors. Their pattern of cytotoxic and cyostatic activity could be related to inhibition of protein tyrosine kinases.
LaBarbera, Daniel V.,Skibo, Edward B.
p. 387 - 395
(2007/10/03)

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Chemical Properties

Appearance/Colour :Orange powder
Melting Point: 60-61 °C
Boiling Point: 385.373 °C at 760 mmHg
Flash Point:186.867 °C
Density: 1.299 g/cm³
Solubility:Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
Storage Temp.:2-8°C
Vapor Pressure: 0mmHg at 25°C
Refractive Index: 1.625
PKA: 14.62±0.10(Predicted)
PSA: 78.08000
LogP: 1.90360

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