- Cyclic Phosphine Oxides and Phosphinamides from Di-Grignard Reagents and Phosphonic Dichlorides: Modular Access to Annulated Phospholanes
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The reaction between 1,4-di-Grignard reagents and phosphonous(III) dichlorides is a classical method for the direct synthesis of phospholanes. Reported here is an extension of this approach to the preparation of value-added, annulated phospholane oxides, achieved through the combination of carbocyclic-fused di-Grignard reagents and readily available phosphonic(V) dichlorides. The procedure is amenable to (benz)annulation at both the 2,3- and 3,4-positions of the phospholane ring, and a variety of aliphatic, cyclic and aryl P-electrophiles are tolerated in reasonable to excellent yields.
- Gregson, Aaron M.,Wales, Steven M.,Bailey, Stephen J.,Willis, Anthony C.,Keller, Paul A.
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p. 9774 - 9780
(2015/10/12)
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- Synthesis and NMR study of cyclohexylphosphonates
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Cyclohexyl-, 2-chlorocyclohex-1-yl and cyclohexen-1-ylphosphonic acids chlorides and fluorides were synthesized and studied by the 1H, 13C, 19F, and 31P NMR methods with the use of correlation spectroscopy and q
- Titov,Zakharov,Krivchun,Ionin
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experimental part
p. 481 - 487
(2011/06/23)
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- A general synthesis of phosphonic acid dichlorides using oxalyl chloride and DMF catalysis
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A general synthesis of phosphonic diacid dichlorides (1) using oxalyl chloride and catalytic DMF is described.
- Rogers, Roland S.
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p. 7473 - 7474
(2007/10/02)
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- A MILD AND FACILE SYNTHESIS OF ALKYL- AND ARYLPHOSPHONYL DICHLORIDES UNDER NEUTRAL CONDITIONS. REACTION OF BIS(TRIMETHYLSILYL) PHOSPHONATES WITH PCl5
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Bis(trimethylsilyl) phosphonates, which are prepared from the dialkyl esters with chlorotrimethylsilane/sodium iodide, are transformed in high yields into the corresponding phosphonyl dichlorides on the treatment with phosphorus pentachloride under mild and neutral conditions.
- Morita, Tsuyoshi,Okamoto, Yoshiki,Sakurai, Hiroshi
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p. 435 - 438
(2007/10/02)
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