- Intermolecular Electrophilic Bromoesterification and Bromoetherification of Unactivated Cyclopropanes
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1,3-difunctionalization of cyclopropane is an useful organic transformation. The corresponding 1,3-difunctionalized products are synthetic synthons and building blocks in many organic syntheses. Many existing ring-opening difunctionalization methodologies rely primarily on the use of donor?acceptor cyclopropanes, while the difunctionalization of unactivated cyclopropanes is less exploited. In this research, 1,3-bromoesterification and 1,3-bromoetherification of unactivated cyclopropanes were successfully achieved using N-bromosuccinimide as the brominating agent with high yields and regioselectivity. (Figure presented.).
- Leung, Vincent Ming-Yau,Gieuw, Matthew H.,Ke, Zhihai,Yeung, Ying-Yeung
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