cas 100570-24-9, (R)-1-(3,4-Dimethoxyphenyl)ethylamine

Articles about 100570-24-9Total 3 be found

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Nonpeptide urotensin-II receptor antagonists: A new ligand class based on piperazino-phthalimide and piperazino-isoindolinone subunits
We have discovered two related chemical series of nonpeptide urotensin-II (U-II) receptor antagonists based on piperazino-phthalimide (5 and 6) and piperazino-isoindolinone (7) scaffolds. These structure types are distinctive from those of U-II receptor antagonist series reported in the literature. Antagonist 7a exhibited single-digit nanomolar potency in rat and human cell-based functional assays, as well as strong binding to the human U-II receptor. In advanced pharmacological testing, 7a blocked the effects of U-II in vitro in a rat aortic ring assay and in vivo in a rat ear-flushmodel. Adiscussion of U-II receptor antagonist pharmacophores is presented, and a specifically defined model is suggested from tricycle 13, which has a high degree of conformational constraint.
Lawson, Edward C.,Luci, Diane K.,Ghosh, Shyamali,Kinney, William A.,Reynolds, Charles H.,Qi, Jenson,Smith, Charles E.,Wang, Yuanping,Minor, Lisa K.,Haertlein, Barbara J.,Parry, Tom J.,Damiano, Bruce P.,Maryanoff, Bruce E.
experimental part
p. 7432 - 7445
(2010/06/19)

HETEROCYCLIC DIAMINE COMPOUNDS AS LIGANDS OF THE MELANIN CONCENTRATING HORMONE RECEPTOR USEFUL FOR THE TREATMENT OF OBESITY, DIABETES, EATING AND SEXUAL DISORDERS
Heterocyclic diamine compounds of formula (I) are provided. Such compounds may be used to modulate MCH receptor activity in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, d
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Page/Page column 44

(2008/06/13)

A facile and efficient asymmetric synthesis of (+)-salsolidine
A three-key step methodology involving a highly selective asymmetric addition of an organolithium reagent to an N-naphthalenylimine, cyclization and oxidative removal of the N-naphthalenyl group provided a facile and efficient synthetic way to (+)-salsolidine. (C) 2000 Elsevier Science Ltd.
Taniyama, Daisuke,Hasegawa, Masayoshi,Tomioka, Kiyoshi
p. 5533 - 5536
(2007/10/03)

Chemical Properties

Boiling Point: 272 °C at 760 mmHg
Flash Point:128.2 °C
Density: 1.037 g/cm³
Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C
Vapor Pressure: 0.00623mmHg at 25°C
Refractive Index: 1.515
PKA: 9.18±0.10(Predicted)
Sensitive: Air Sensitive
BRN: 8616003
PSA: 44.48000
LogP: 2.42380

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Chemical Properties

Boiling Point: 272 °C at 760 mmHg

Flash Point:128.2 °C

Density: 1.037 g/cm³

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Vapor Pressure: 0.00623mmHg at 25°C

Refractive Index: 1.515

PKA: 9.18±0.10(Predicted)

Sensitive: Air Sensitive

BRN: 8616003

PSA: 44.48000

LogP: 2.42380

Global suppliers and manufacturers of 100570-24-9total 23 suppliers on LookChem

Article Database

100570-24-9

Articles about 100570-24-9Total 3 be found

More Articles about upstream products of 100570-24-9

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Chemical Properties

Boiling Point: 272 °C at 760 mmHg

Flash Point:128.2 °C

Density: 1.037 g/cm3

Storage Temp.:under inert gas (nitrogen or Argon) at 2–8 °C

Vapor Pressure: 0.00623mmHg at 25°C

Refractive Index: 1.515

PKA: 9.18±0.10(Predicted)

Sensitive: Air Sensitive

BRN: 8616003

PSA: 44.48000

LogP: 2.42380

Global suppliers and manufacturers of 100570-24-9total 23 suppliers on LookChem

Density: 1.037 g/cm³