- 1 - Benzoyl -3 - (2 - hydroxy - 1, 1 - dimethyl ethyl) thiourea synthesis method
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The invention relates to a method for preparing an organic compound, in particular to a method for compounding 1-benzoyl-3-(2-oxhydryl-1,1-dimethylethyl) thiourea, which comprises the steps: an organic solvent and a raw material, namely 2-amido-2-methylpr
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Paragraph 0012-0025
(2019/05/04)
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- BENZOXEPIN PI3K INHIBITOR COMPOUNDS AND METHODS OF USE
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Benzoxepin compounds of Formula I, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, wherein: Z1 is CR1 or N; Z2 is CR2 or N; Z3 is CR3 or N; Z4 is CR4 or N; and where (i) X1 is N and X2 is S, (ii) X1 is S and X2 is N, (iii) X1 is CR7 and X2 is S, (iv) X1 is S and X2 is CR7; (v) X1 is NR8 and X2 is N, (vi) X1 is N and X2 is NR8, (vii) X1 is CR7 and X2 is O, (viii) X1 is O and X2 is CR7, (ix) X1 is CR7 and X2 is C(R7)2, (x) X1 is C(R7)2 and X2 is CR7; (xi) X1 is N and X2 is O, or (xii) X1 is O and X2 is N, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
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Page/Page column 204
(2011/04/19)
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- Pyrrolidine and related derivatives useful as PR modulators
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Compounds of the following structure are described: wherein R1-R6, R11, R12, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compou
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Page/Page column 16
(2010/11/30)
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- Tricyclic oxazolidone derivatives useful as PR modulators
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Compounds of the following structure are described: wherein R1-R6, R16, m, V, W, X, Y, and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are use
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Page/Page column 16
(2008/06/13)
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- Oxazolidone derivatives as PR modulators
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Compounds of the following structure are described: wherein R1, R2, R5, R6, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a variety of hormone-related conditions including contraception, treating or preventing fibroids, endometriosis, dysfunctional bleeding, uterine leiomyomata, polycystic ovary syndrome, or hormone-dependent carcinomas, providing hormone replacement therapy, stimulating food intake or synchronizing estrus.
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Page/Page column 25
(2008/06/13)
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- Oxazolidine derivatives as PR modulators
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Compounds of the following structure are described: wherein R1-R6, m, V, W, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful for treating a
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Page/Page column 15-16
(2010/11/30)
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- Imidazolidin-2-one derivatives useful as PR modulators
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Compounds of the following structure are described: wherein R1-R6, R10, m, V, X, Y, Z and Q are described herein, or a pharmaceutically acceptable salt, tautomer, metabolite or prodrug thereof. These compounds are useful f
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Page/Page column 16
(2010/11/30)
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