Metal-Free One-Pot Synthesis of 3-Phosphinoylbenzofurans via Phospha-Michael Addition/Cyclization of H-Phosphine Oxides and in Situ Generated ortho-Quinone Methides
A novel metal-free one-pot protocol for the effective and efficient synthesis of 3-phosphinoylbenzofurans via a phospha-Michael addition/cyclization of H-phosphine oxides and in situ generated ortho-quinone methides is described. Based on the expeditious
Du, Ji-Yuan,Ma, Yan-Hua,Yuan, Rui-Qing,Xin, Nana,Nie, Shao-Zhen,Ma, Chun-Lin,Li, Chen-Zhong,Zhao, Chang-Qiu
supporting information
p. 477 - 480
(2018/01/28)
Lewis Acid Catalyzed Tandem 1,4-Conjugate Addition/Cyclization of in Situ Generated Alkynyl o-Quinone Methides and Electron-Rich Phenols: Synthesis of Dioxabicyclo[3.3.1]nonane Skeletons
A versatile Lewis acid catalyzed tandem cyclization of in situ generated alkynyl o-quinone methides (o-AQMs) with electron-rich phenols has been developed on the basis of the mode involving an intermolecular 1,4-conjugate addition/6-endo cyclization/1,3-a
Du, Ji-Yuan,Ma, Yan-Hua,Meng, Fan-Xiao,Chen, Bao-Li,Zhang, Shao-Liang,Li, Qian-Li,Gong, Shu-Wen,Wang, Da-Qi,Ma, Chun-Lin
supporting information
p. 4371 - 4374
(2018/07/29)
Synthesis of chromones through LiOtBu/air-mediated oxidation and regioselective cyclization of o-hydroxyphenyl propargyl carbinols
A cascade oxidative cyclization reaction for the synthesis of chromone derivatives was developed by using LiOtBu as a mediator and air as an oxidant. The reaction was carried out without the assistance of a transition metal under mild conditions to afford the chromones in good yields with high regioselectivities. A tandem reaction for the synthesis of various chromones was developed. LiOtBu was used as a mediator and air was used as a clean oxidant. The reaction generally showed high regioselectivity under mild conditions. Extensive research showed that dehydrogenative oxidation of the alcohols under strongly basic conditions was the crucial step, and Li+ was also found to play an important role in this process. Copyright
Water-promoted, silver-phosphine complex-catalyzed stereoselective cyclization of 2-(1-Hydroxy-3-arylprop-2-ynyl)phenols leading to a highly efficient approach to aurones
Silver-phosphine complexes can be utilized as highly efficient catalysts for the cyclization of 2-(1-hydroxy-3-arylprop-2-ynyl)phenols (1) to give product 2, key intermediates to synthesize aurones (4), with good yields and stereoselectivities in water-to
Versatile and expeditious synthesis of aurones via AuI-catalyzed cyclization
(Chemical Equation Presented) Aurones are conveniently formed in a three-step procedure including a goldI-catalyzed cyclization of 2-(1-hydroxyprop-2-ynyl)phenols as a highly regio- and stereoselective key step. A wide diversity of derivatives can be obtained starting from substituted salicylaldehydes. Synthesis of natural 4,6,3′,4′-tetramethoxyaurone and structure revision of two natural products (dalmaisione D and 4′-chloroaurone) were achieved.
Harkat, Hassina,Blanc, Aurelien,Weibel, Jean-Marc,Pale, Patrick
p. 1620 - 1623
(2008/09/16)
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