- Synthesis of some biginelli compounds in solvent medium using a photochemistry method
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Some Biginelli compounds were synthesized by using a photochemistry method. The Biginell three-component cyclocondensation reactions in THF medium using a mixture of β-ketoester or β-diketone, arylaldehyde and (thio)urea under irradiation with a Wolframe
- Foroughifar,Mobinikhaledi,Fathinejad Jirandehi
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- Dihydropyrimidinone/1,2,3-triazole hybrid molecules: Synthesis and anti-varicella-zoster virus (VZV) evaluation
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By combining the structural features of dihydropyrimidinone and 1,2,3-triazole heterocycles, novel hybrid compounds were synthesized using a simple and convenient method. A series of novel mono and bis 1,2,3-triazole was synthesized via copper-catalyzed Huisgen azide-alkyne cycloadditions (CuAAC) under microwave irradiation. The newly synthesized compounds were evaluated for their antiviral activity against varicella-zoster virus (VZV). Compounds 6aa, 7ab, 6ba and 6da showed valuable antiviral activities, with EC50 values ranging from 3.6 to 11.3 μM against TK+ and TK- VZV and without measurable cell-growth inhibition.
- Kaoukabi, Hanane,Kabri, Youssef,Curti, Christophe,Taourirte, Moha,Rodriguez-Ubis, Juan C.,Snoeck, Robert,Andrei, Graciela,Vanelle, Patrice,Lazrek, Hassan B.
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supporting information
p. 772 - 781
(2018/06/26)
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- QSAR analysis of 2-oxo-1,2,3,4-tetrahydropyrimidine analogues of antibacterials
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QSAR analysis of two sets of analogues of 2-oxo-1,2,3,4- tetrahydropyrimidine was performed to investigate the relationship between their physicochemical parameters and antibacterial activity. Predictive and statistically significant models were generated
- Sawant, Ramesh L.,Bhatia, Manish S.
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experimental part
p. 1361 - 1373
(2010/04/28)
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