cas 100959-19-1, 4-METHYLCYCLOHEXYLAMINE HYDROCHLORIDE | Articles data ｜lookchem

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100959-19-1

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A NOVEL PROCESS FOR PREPARATION OF SUBSTANTIALLY PURE GLIMEPIRIDE
The present invention discloses a novel process for purification of trans-4-methyl cyclohexylamine HC1 and 4-[2-(3-Ethyl-4-methyl-2-carbonyl pyrrolidine amido) ethyl] benzene sulfonamide used in the synthesis of 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methyl cyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide(I), popularly known as Glimepiride. The present invention also discloses a novel purification of Glimepiride Form I (I), having the undesired cis isomer below 0.15%. Glimepiride (I) is useful in the treatment of diabetes mellitus.
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Page/Page column 8, 13-14

(2010/11/24)

Compound and use of the same as medicine
Disclosed herein is a specific cinnamic acid derivative such as methyl 4-(4-acetoxy-3-methoxycinnamanide)-1-cyclohexanecarboxylate, or a pharmaceutically acceptable salt thereof. These compounds are useful as IV-type allergic reaction-suppressive drugs.
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(2008/06/13)

More Articles about upstream products of 100959-19-1

4994-13-2
4-methylcyclohexanone oxime

More Articles about downstream products of 100959-19-1

Chemical Properties

Melting Point: 224°C (dec.)
Boiling Point: 195.9°C at 760 mmHg
Flash Point:72.3°C
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 0.347mmHg at 25°C
Sensitive: Hygroscopic
BRN: 3670820
PSA: 26.02000
LogP: 3.02610

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