- Synthesis, characterization, optical and electrochemical properties and antifungal and anticancer activities of ferrocenyl conjugated novel dendrimers
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A new class of triazoloferrocenyl conjugates (1, 2 and 3) was obtained by copper(i) catalyzed click chemistry, specifically the alkyne azide cycloaddition (CuAAC) of bis(β-hydroxyl)arylalkyneether with suitable ferrocenyl azides. The synthesized bis(β-hydroxyl)arylether linked ferrocenyl conjugates 1, 2 and 3 exhibit antifungal activity against fungal pathogens, viz. Candida albicans, Candida glabrata and Candida crusi, comparable to that of amphotericin B and also show excellent anticancer activity against MCF-7 cell lines.
- Saravanan, Velautham,Kannan, Ayyavoo,Rajakumar, Perumal
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- Synthesis and properties of biobased epoxy resins. part 1. Glycidylation of flavonoids by epichlorohydrin
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Biobased epoxy resins were synthesized from a catechin molecule, one of the repetitive units in natural flavonoid biopolymers also named condensed tannins. The reactivity of catechin toward epichlorohydrin to form glycidyl ether derivatives was studied using two model compounds, resorcinol and 4-methylcatechol, which represent the A and B rings of catechin, respectively. These model molecules clearly showed differences in reactivity upon glycidylation, explaining the results found with catechin monomer. The reaction products were characterized by both FTIR and NMR spectroscopy and chemical assay. The glycidyl ether of catechin (GEC) was successfully cured in various epoxy resin formulations. The GECs thermal properties showed that these new synthesized epoxy resins displayed interesting properties compared to the commercial diglycidyl ether of bisphenol A (DGEBA). For instance, when incorporated up to 50% into the DGEBA resin, GEC did not modify the glass-transition temperature. Epoxy resins formulated with GEC had slightly lower storage moduli but induced a decrease of the swelling percentage, suggesting that GEC-enhanced crosslinking in the epoxy resin networks.
- Nouailhas, Helene,Aouf, Chahinez,Le Guerneve, Christine,Caillol, Sylvain,Boutevin, Bernard,Fulcrand, Helene
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- Synthesis of novel poly(hydroxyether terephthalate) via polyaddition of 2,5-difluoroterephthalic acid with aromatic bis(epoxide)s
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A novel and more reliable synthetic route to 2,5-difluoroterephthalic acid was developed. A series of new poly(hydroxyether terephthalate) were prepared by the polyaddition of 2,5-difluoroterephthalic acid with various aromatic bis(epoxide)s catalyzed by tetrabutyl ammonium bromide.
- Huang, Xiao-Song,Qing, Feng-Ling
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experimental part
p. 1076 - 1082
(2009/04/07)
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