Squalene synthase inhibitors: Isosteric replacements of the farnesyl chain of benzyl farnesyl amine
Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibitor ben
Brinkman, John A.,Damon, Robert E.,Fell, Jay B.,Perez, Lawerence B.,Scallen, Terence J.,Vedananda
Synthesis and Physicochemical Characterization of Fluorescent (E)-2-Stilbenyloxyalkylthiouracils and Isomer Differentiation using EIMS
Twelve new fluorescent (E)-2-stilbenyloxyalkylthiouracils and 6-methyluracils 5a-5I were prepared. EI induced mass spectral fragmentation of these compounds was investigated. Fragmentation pathways are proposed on the basis of accurate mass and metastable
Wyrzykiewicz, Elzbieta,Wendzonka, Monika
p. 177 - 186
(2007/10/03)
Further studies on derivatives of stilbenes & diphenylethane. VIII.
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MASSARANI,CAVALLINI,NARDI,FERRARI
p. 329 - 337
(2007/10/06)
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