- Photodriven Photocatalyst/Metal-Free Direct C-C/C-N Bond Formation: Synthesis of Indoles via EDA Complexes
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The photodriven direct C-C/C-N bond formation initiated by electron donor-acceptor (EDA) complexes for the synthesis of indoles has been accomplished via [3+2] annulations of secondary arylamines with alkynes using IC4F9 as oxidants in the absence of any photocatalysts and metals. This green transformation exhibits the advantages of operational simplicity, good functional tolerances, and mild reaction conditions. The in situ generated EDA complexes derived from arylamines with alkynes were characterized by UV-vis absorption spectrometry and NMR titration experiments.
- Guo, Wei,Tao, Kailiang,Xie, Zhen,Cai, Liuhuan,Zhao, Mingming,Tan, Wen,Liu, Gongping,Mei, Weijie,Deng, Ling,Fan, Xiaolin,Zheng, Lvyin
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- ACYLAMINO BRIDGED HETEROCYCLIC COMPOUND, AND COMPOSITION AND APPLICATION THEREOF
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Provided are an acylamino bridged heterocyclic compound of formula (I) or a pharmaceutically acceptable salt, an isomer, a solvate, a crystal, or a prodrug thereof, and a pharmaceutical composition comprising the compound, and an application of the compou
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- Highly Efficient Binuclear Copper-catalyzed Oxidation of N,N-Dimethylanilines with O2
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A binuclear copper-salicylate complex, [Cu(Sal)2(NCMe)]2 (Sal=salicylate), was found to be an active catalyst for the oxidation of N,N-dimethylanilines by O2, affording the corresponding N-methyl-N-phenylformamides as major products. The reactions were carried out with a O2 balloon and the S/C (substrate/catalyst ratio) of the model reaction could be up to 1×105, providing a practical and highly efficient catalytic protocol for accessing N-methyl-N-phenylformamides.
- Liu, Yuxia,Yan, Yonggang,Xue, Dong,Wang, Zhongfu,Xiao, Jianliang,Wang, Chao
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p. 2221 - 2225
(2020/03/23)
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- Efficient ruthenium-catalyzed N-methylation of amines using methanol
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An in situ-generated complex from [RuCpCl2]2 and dpePhos ligand is reported as an efficient catalyst in the presence of 5 mol % of LiOtBu for the N-methylation of amines using methanol as the methylating agent at moderate conditions, following hydrogen borrowing strategy. This simple catalyst system provides selective N-monomethylation of substituted primary anilines and sulfonamides as well as N,N dimethylation of primary aliphatic amines in excellent yields at 40-100 °C with good tolerance to reducible functional groups. The catalytic intermediate CpRu(dpePhos)H was isolated and was shown to be active for methylation in the absence of base.
- Dang, Tuan Thanh,Ramalingam, Balamurugan,Seayad, Abdul Majeed
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p. 4082 - 4088
(2015/11/11)
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- NOVEL BIAROMATIC COMPOUNDS THAT ACTIVATE PPAR TYPE RECEPTORS, AND USE THEREOF IN COSMETIC OR PHARMACEUTICAL COMPOSITIONS
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The invention relates to novel biaromatic compounds that correspond to the general formula (I) and also to the method for preparing them, and to their use in pharmaceutical compositions for use in human or veterinary medicine (in dermatology, and also in the field of cardiovascular diseases, immune diseases and/or lipid metabolism-related diseases), or alternatively in cosmetic compositions.
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Page/Page column 47
(2010/10/20)
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- 1H, 2H, 19F, 14N ENDOR and TRIPLE Resonance Investigations of Substituted Flavin Radicals in Their Different Protonation States
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A variety of isotopically labelled and/or substituted flavins have been converted into their corresponding radical states.Cation and neutral radicals were generated chemically and anion radicals were obtained electrochemically.By performing ENDOR and TRIPLE resonance experiments, complete sets of hyperfine coupling constants including their signs were accessible.The hyperfine data allowed (a) identification of the radical state present, (b) information to be obtained about the preferred conformational arrangements of the substituents and (c) conclusions to be drawn about the influences of the substituents on the spin density distributions of the different radical states. - KEY WORDS: ENDOR, TRIPLE resonance spectroscopy; Flavin radicals; Electrochemical generation of radicals.
- Weilbacher, E.,Helle, N.,Elsner, M.,Kurreck, H.,Mueller, F.,Allendoerfer, R. D.
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