Direct Conversion of Haloarenes to Phenols under Mild, Transition-Metal-Free Conditions
A high-yielding and practical method for the synthesis of phenols from electron-deficient haloarenes and heteroarenes has been developed. The products are formed from acetohydroxamic acid as the hydroxide source via a novel SNAr reaction/Lossen rearrangement sequence. Notably, these reactions employ inexpensive and air-stable reagents, require no special handling, occur under mildly basic conditions, and form products in high yields in the presence of electrophilic and protic functionality. The utility of this methodology is demonstrated by the high-yielding hydroxylation of two base-sensitive complex substrates.
Fier, Patrick S.,Maloney, Kevin M.
supporting information
p. 2244 - 2247
(2016/06/01)
Synthesis and biological evaluation of pyridin-2-one nucleosides
The synthesis of 1-(β -D-ribofuranosyl)pyridin-2-one-3-carboxylic acid and the 3-carboxamide as well as a short series of 3N-carboxamides, prepared by TPTU/HOBt coupling of primary amines with 1- (β-D-ribofuranosyl)pyridin-2-one-3-carboxylic acid, and the
Huntley,Cotterill,Maillard,Balzarini,Simons
p. 731 - 733
(2007/10/03)
The deoxydative substitution reactions of nicotinamide and nicotinic acid N-oxides by 1-adamantanethiol in acetic anhydride
-
Prachayasittikul,Bauer
p. 771 - 775
(2007/10/02)
More Articles about upstream products of 10128-92-4