Small Molecule Agonists and Antagonists of NR2F6 Activity in Humans
The present technology is directed to modulators of nuclear receptor activity, specifically to the modulation of NR2F6 activity and NR2F6 utilizing compounds, and the immune modulation and modulation of cancer stem cell activity through administration of
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Paragraph 0066; 0260
(2018/08/20)
Three-component coupling approach to trachyspic acid
Three-component coupling of the lithium enolate of t-BuOAc, silyl glyoxylate, and an α,β-unsaturated ketone enables the rapid construction of the trachyspic acid carbon skeleton. A 3,4-disubstituted isoxazole is utilized to mask the C7/C9 dicarbonyl. New
Schmitt, Daniel C.,Lam, Leighann,Johnson, Jeffrey S.
supporting information; experimental part
p. 5136 - 5139
(2011/11/29)
Synthesis of 3-aminomethyl-substituted pyrazoles and isoxazoles
A series of new 3-(aminomethyl)pyrazoles and 3-(aminomethyl)isoxazoles was synthesized along a route involving the formation as key intermediates of esters of 5-substituted 1H-pyrazole-3-carboxylic and 1H-isoxazole-3-carboxylic acids. All compounds obtain
Musatov,Starodubtseva,Rakishev,Turova,Vinogradov
experimental part
p. 1199 - 1203
(2011/12/15)
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