- Triple aryne-tetrazine reaction enabling rapid access to a new class of polyaromatic heterocycles
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One of the most challenging goals of modern synthetic chemistry is to develop multi-step reactions for rapid and efficient access to complex molecules. We report a triple aryne-tetrazine reaction that enables rapid access to a new class of polyaromatic heterocycles. This new reaction, which couples diverse reactivity modes between simple aryne and tetrazine starting materials, proceeds in a single operation and takes less than 5 minutes in air with no metal catalyst.
- Suh, Sung-Eun,Barros, Stephanie A.,Chenoweth, David M.
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- A concise method to prepare linear 2,3-diazaoligoacene derivatives
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In this Letter, we demonstrate that linear 2,3-diazanaphthalene (1), 2,3-diazaanthracene (2), and 2,3-diazatetracene (3) can be easily prepared through [4+2] cycloaddition reaction between 3,6-diphenyl-1,2,4,5-tetrazine as the diene and arynes as dienophiles, generated in situ from ortho- aminoarylcarboxylic acids. The physical properties and crystal packing of the prepared compounds 1-3 were fully investigated. In addition, the experimental data (e.g., band gap and band position) are further confirmed by theoretical studies.
- Li, Junbo,Gao, Junkuo,Xiong, Wei-Wei,Zhang, Qichun
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- Red-emitting electrophosphorescent devices
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This invention relates to an organic electroluminescence (EL) device and to the use of a tris-cyclometalated iridium complex with a 3-Phenyl-azine ligand for thin-film type organic electroluminescence devices. The iridium complexes used have the following
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- NOVEL USE OF TRICYCLIC COMPOUND
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Pharmaceutical compositions for enhancing the expression of apoAI are provided, which are used as medicaments for treatment of cardiovascular diseases on the basis of improving the functions of HDL.Pharmaceutical compositions for enhancing the expression of apoAI which comprises a compound of formula (I): in which X1 and X2 are independently an aryl or heteroaryl that may be optionally substituted, a hydrogen, a halogen, or the like; ring A is a benzene ring or 6-membered aromatic heterocyclic ring containing 1 to 3 N atoms that may be optionally condensed with another aromatic ring; R1 to R4 are independently a hydrogen, a halogen, a lower alkyl, a lower alkoxy or the like; a prodrug thereof, a pharmaceutically acceptable salt or solvate of them are disclosed.
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Page/Page column 14-15; 17
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- THE GENERATION AND REACTIONS OF C,N-DIANIONS OF AROMATIC TOSYLHYDRAZONES: ortho-N-DILITHIATED BENZOPHENONE TOSYLHYRAZONE
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The ortho, N-dilithiated derivative of the tosylhydrazone of benzophenone (5) has been generated by metal-halogen exchange at low temperature.A range of alkylation, silylation and acylation reactions are described together with further reactions leading to 1,2-diacylbenzenes, phthalazines, 1,3-diphenylisobenzofuran, and a 1,2,3-diazaborine.
- Sharp, John T.,Skinner, Carol E. D.
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p. 869 - 872
(2007/10/02)
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- Synthesis and Reactions of 2,3-Dihydro-oxazoloisoindol-5(9bH)-ones
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The synthesis and reactions with nucleophiles of 2,3-dihydro-oxazoloisoindol-5(9bH)-ones are described.
- Wharton, Clifford J.,Wrigglesworth, Roger
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p. 809 - 814
(2007/10/02)
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