MegaStokes BODIPY-triazoles as environmentally sensitive turn-on fluorescent dyes
A novel class of triazole-derivatized BODIPY compounds have been synthesized on solid-phase by employing mild reaction conditions based on the copper-catalyzed azide-alkyne cycloaddition. The resulting BODIPY-triazoles exhibited MegaStokes shifts (up to 160 nm) and remarkable environmentally sensitive quantum yield increments that asserted their potential as turn-on fluorescent sensors. Out of a library of 120 compounds, we identified BDC-9 as a fluorescent chemosensor with high sensitivity and remarkable species-selectivity towards human serum albumin. These results validate MegaStokes BODIPY dyes as new fluorophores for the development of environmentally sensitive fluorescent probes.
Er, Jun Cheng,Tang, Mui Kee,Chia, Chee Geng,Liew, Huimin,Vendrell, Marc,Chang, Young-Tae
MEGASTOKES AMINO-TRIAZOLYL-BODIPY COMPOUNDS AND APPLICATIONS TO LIVE NEURON STAINING AND HUMAN SERUM ALBUMIN FA1 DRUG SITE PROBING
A library of novel amino-triazolyl-BODIPY compounds is described. Particular compounds of the library serve as selective fluorescent probes Human Serum Albumin (HSA) and for live primary neurons. The fluorescent probe for HSA binds uniquely and specifically to the fatty acid site 1 of HSA, and thus proves a valuable and unique probe for drugs that bind to such a site on HSA. Methods of synthesis for the library compounds are also described.
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(2014/07/21)
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