- On water phosphine-free palladium-catalyzed room temperature C-H arylation of indoles
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Get on top of your chemistry! An "on water", palladium-catalyzed, phosphine-free direct C-H arylation of indoles, with iodoarenes at 25-30°C, is disclosed (see scheme; TBDMS=N-tert-butyldimethylsilyl ether; SEM=N-2-(trimethylsilyl)ethoxymethyl; Bn=benzyl, Piv=pivabyl). The mildness of the reaction conditions permits the tolerance of a variety of N1-protected indoles.
- Islam, Saidul,Larrosa, Igor
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- Room temperature and phosphine free palladium catalyzed direct C-2 arylation of indoles
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We report the first room-temperature direct C-2 arylation of indoles with iodoarenes by using a highly electrophilic palladium catalyst generated in situ from Pd(OAc)2 and a silver carboxylate. These mild conditions permit a broad set of functionalities both in the indole and in the aryl iodide units such as free alcohols, phenols, aldehydes, bromides, or nitriles, thus allowing the synthesis of a variety of novel compounds in excellent yields. Copyright
- Lebrasseur, Nathalie,Larrosa, Igor
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p. 2926 - 2927
(2008/09/19)
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