- Synthesis of 2-(chloro(methoxy, morpholino)methyl)-hexahydropyrimidothieno[3,2-c]azocines and tetrahydrospiro[pyrido[4,5']thieno[2,3-d]pyrimidines]
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2-(Chloromethyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-ones reacted with acetylenedicarboxylate ester, methyl propiolate or acetylacetylene, forming mixtures of 2-(chloromethyl)-5,6,7,10-tetrahydropyrimido[5',4':4,5]thieno[3,2-d]
- Voskressensky, Leonid G.,Kovaleva, Svetlana A.,Borisova, Tatiana N.,Titov, Alexander A.,Toze, Flavien,Listratova, Anna V.,Khrustalev, Viktor N.,Varlamov, Alexey V.
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- An unusual Michael addition-dealkylation or elimination via the reaction of tertiary or secondary amines with a (Z)-iodoacrylate
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A series of (E)-ammonium or amino acrylates have been prepared via the Michael addition of methyl (Z)-iodoacrylate and several secondary and tertiary alkylamines. Tertiary amines undergo concomitant addition-dealkylation, almost quantitatively producing (
- Maw, Graham,Thirsk, Carl,Whiting, Andrew
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p. 8387 - 8390
(2007/10/03)
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