Identification of CKD-516: A potent tubulin polymerization inhibitor with marked antitumor activity against murine and human solid tumors
Tubulin polymerization inhibitors had emerged as one of promising anticancer therapeutics because of their dual mechanism of action, i.e. apoptosis by cell-cycle arrest and VDA, vascular disrupting agent. VDAs are believed to be more efficient, less toxic
Lee, Jaekwang,Kim, Soo Jin,Choi, Hojin,Kim, Young Hoon,Lim, In Taek,Yang, Hyun-Mo,Lee, Chang Sik,Kang, Hee Ryong,Ahn, Soon Kil,Moon, Seung Kee,Kim, Dal-Hyun,Lee, Sungsook,Choi, Nam Song,Lee, Kyung Joo
experimental part
p. 6337 - 6354
(2010/10/21)
BENZOPHENONE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE
Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeuti
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Page/Page column 52-53
(2009/12/02)
BENZOPHENONE DERIVATIVES USEFUL FOR INHIBITING FORMATION OF MICROTUBULE
Disclosed herein are novel benzophenone derivatives represented by formula I, a pharmaceutically acceptable salt thereof, a hydrate thereof or a solvate thereof, a pharmacological composition containing the same, and a use of the composition as therapeutic drugs. The benzophenone derivatives have an inhibition activity of microtubule formation and can be used to treat a normal proliferative state of a malignant tumor by killing the actively proliferating cells.
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Page/Page column 65
(2008/06/13)
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